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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
MC1R
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "MC1R" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-P2336A
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1 Cited Publications
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THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants [1] .
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Metabolic Disease Inflammation/Immunology Endocrinology Cancer
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1 Cited Publications
Cat. No.: HY-N2466A
CAS No.: 1566590-77-9
Synonyms: MT-I acetate; [Nle4,D-Phe7]-α-MSH acetate
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Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Synonyms: MT-7117
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Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation [1] .
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JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
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BMS-470539 dihydrochloride is a highly potent and selective melanocortin-1 receptor (MC-1R) agonist with an IC50 of 120 nM, an EC50 of 28 nM. BMS-470539 dihydrochloride does not activate MC-3R and is a very weak partial agonist at MC-4R and MC-5R. BMS-470539 dihydrochloride has potently anti-inflammatory properties [1] .
Cat. No.: HY-P1726
CAS No.: 1416983-77-1
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Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cat. No.: HY-P5247
Synonyms: PTP20
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Cat. No.: HY-P2242A
CAS No.: 1373926-49-8
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Cat. No.: HY-P5247A
Synonyms: PTP20 TFA
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Cat. No.: HY-129724
CAS No.: 67727-97-3
Synonyms: ACTH-(11-13); Lys-Pro-Val; H-Lys-Pro-Val-OH
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Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Cat. No.: HY-RS08200
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MC1R Human Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08201
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Mc1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08202
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MC1R Rat Pre-designed siRNA Set A contains three designed siRNAs for MC1R gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P2242
CAS No.: 274682-89-2
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Cat. No.: HY-P2336
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Cat. No.: HY-P11293
CAS No.: 1309855-53-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
