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MLKs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Mixed Lineage Kinase (12) Aldose Reductase (1) Apoptosis (2) Autophagy (1) CaMK (1) Casein Kinase (3) COX (2) DYRK (1) FAK (1) Interleukin Related (3) IRAK (3) JNK (3) LRRK2 (1) MAP4K (1) MDM-2/p53 (1) MEK (2) Microtubule/Tubulin (1) MNK (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) RIP kinase (1) Tau Protein (1) TNF Receptor (3)
By Research Areas:	Cancer (9) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (8)

Inhibitors & Agonists

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Products

Targets Recommended: Mixed Lineage Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147141

HS-276 2 Publications Verification	IRAK TNF Receptor Casein Kinase Interleukin Related	Inflammation/Immunology
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .

HY-12599

URMC-099 Maximum Cited Publications 7 Publications Verification	Mixed Lineage Kinase Autophagy	Neurological Disease Cancer
URMC-099 is an orally bioavailable and potent mixed lineage kinase type 3 (MLK3) (IC₅₀=14 nM) inhibitor with with excellent blood-brain barrier penetration properties.

HY-10412

CEP-1347 KT7515	JNK Mixed Lineage Kinase MDM-2/p53	Neurological Disease
CEP-1347 is an inhibitor of the JNK/SAPK pathway with neuroprotective effects. CEP-1347 blocks JNK1 activation induced by members of the mixed lineage kinase (MLK) family (MLK3, MLK2, MLK1, dual leucine zipper kinase, and leucine zipper kinase). As an inhibitor of MDM4, CEP-1347 can more effectively inhibit the growth of glioma cells expressing wild-type p53 .

HY-148907

CS640	CaMK MEK Mixed Lineage Kinase RIP kinase Tau Protein	Neurological Disease
CS640 (Compound 19) is a chemical probe and a calmodulin-dependent kinase inhibitor. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, MEK5, RIPK4, *mLK3* and PIP5K1, with IC₅₀ values of 8, 3, 1, 1, 25 nM, 5.69, 2.75 and 11.2 μM, respectively. CS640 blocks Aβ-induced hyperphosphorylation of tau protein at the Thr181 site, but fails to protect primary mouse cortical neurons from Aβ-induced toxic damage. CS640 is applicable to research related to Alzheimer's disease .

HY-13488

HG-10-102-01 1 Publications Verification	LRRK2 MNK	Neurological Disease
HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC₅₀ values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits MNK2 and *MLK1, with IC₅₀* values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research .

HY-168972

Famlasertib Prostetin/12k	MAP4K Mixed Lineage Kinase	Neurological Disease Inflammation/Immunology
Famlasertib is a potent, brain-penetrant MAP4K inhibitor with IC₅₀s value of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively. Famlasertib shows motor neuron protection and anti-inflammatory properties. Famlasertib can be used for the study of amyotrophic lateral sclerosis (ALS) .

HY-111351

MLK-IN-1	Mixed Lineage Kinase	Neurological Disease
MLK-IN-1 is a potent, brain penetrant and specific mixed lineage kinase 3 (MLK-3) inhibitor, compound 68, extracted from patent US20140256733A1 .

HY-177416

MU1787	DYRK	Cancer
MU1787 is a highly selective homeodomain-interacting protein kinase (HIPK) inhibitor with a furopyridine core, and shows improved selectivity against CLKs, with inactivity against DYRK1B, DYRK2, and *MLK2/3* in in vitro cellular assays. MU1787 can be used for the research of malignancies .

HY-121683

(E)-2-Hexadecenal 16:1 Aldehyde; trans-2-Hexadecenal	Mixed Lineage Kinase Apoptosis JNK Microtubule/Tubulin	Cancer
(E)-2-Hexadecenal (trans-2-Hexadecenal) is an *MLK3* activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the *MLK3* signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways .

HY-120349

LL-Z1640-4	p38 MAPK JNK Apoptosis Reactive Oxygen Species (ROS)	Cancer
LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4 .

HY-N0811

Anemarsaponin B	NO Synthase COX NF-κB MEK	Inflammation/Immunology
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-170486

MLK3-IN-1	Mixed Lineage Kinase FAK	Cancer
MLK3-IN-1 (Compound 37) is a selective inhibitor for mixed-lineage protein kinase 3 (MLK3) with an IC₅₀ <1 nM. MLK3-IN-1 inhibits FAK with an IC₅₀ of 15.5 μM. MLK3-IN-1 exhibits good metabolic stability in mouse and human liver microsomes .

HY-E70800

*Biotin-MLK2 Recombinant Human Active Protein Kinase*	Mixed Lineage Kinase	Cancer
MLK2 is a kinase for phosphorylation of H3 at threonine 3 and is associated with the osmotic stress response. MLK2 is involved in multiple signaling pathways in the developmental process. Biotin-MLK2 Recombinant Human Active Protein Kinase is obtained by expressing MLK2 proteins and is biotinylated .

HY-E70799

*Biotin-MLK1 Recombinant Human Active Protein Kinase*	Mixed Lineage Kinase	Cancer
MLK1 is a kinase for phosphorylation of H3 at threonine 3 and is associated with the osmotic stress response. MLK1 is involved in multiple signaling pathways in the developmental process. Biotin-MLK1 Recombinant Human Active Protein Kinase is obtained by expressing MLK1 proteins and is biotinylated .

HY-161271

MLK-IN-2	Mixed Lineage Kinase	Neurological Disease Cancer
MLK-IN-2 (Compound 9a) is a Mixed Lineage Kinase 3 (MLK3) inhibitor containing 3H-imidazole [4,5-b] pyridine structure. IC₅₀ value is 6 nM. MLK-IN-2 can be used to study cancer and neurodegenerative diseases .

HY-N3716

Dehydroglyasperin D	Aldose Reductase COX	Metabolic Disease Inflammation/Immunology
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

HY-180338

MLK-IN-3	Mixed Lineage Kinase	Neurological Disease
MLK-IN-3 (Compound 30) is a *MLK* inhibitor with an IC₅₀ of less than 5 μM. MLK-IN-3 can be used in the research of neurological diseases .

HY-168026

CEP1347-VHL-02	PROTACs Mixed Lineage Kinase	Cancer
CEP1347-VHL-02 is a PROTAC targeting *MLK3*. CEP1347-VHL-02 consists of PROTAC target protein ligand CEP-1347 (HY-10412) (red part), E3 ubiquitin ligase ligand (S,R,S)-AHPC-Me (HY-112078) (blue part) and PROTAC Linker Amino-PEG3-CH2COOH (HY-140189) (black part), of which the target protein ligand activity control is CEP-1347-acid (HY-168027), and the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 (HY-131387) ^{[1] ^.}

HY-147141A

HS-276 hydrochloride	IRAK TNF Receptor Casein Kinase Interleukin Related	Inflammation/Immunology
HS-276 hydrochloride is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 hydrochloride shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 hydrochloride reduces the expression of TNF, IL-6, and IL-1β. HS-276 hydrochloride can be used for rheumatoid arthritis (RA) research .

HY-147141B

HS-276 formic	IRAK TNF Receptor Casein Kinase Interleukin Related	Inflammation/Immunology
HS-276 formic is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 formic shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 formic reduces the expression of TNF, IL-6, and IL-1β. HS-276 formic can be used for rheumatoid arthritis (RA) research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0811

Anemarsaponin B	Liliaceae Classification of Application Fields Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	NO Synthase COX NF-κB MEK
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of NF-κB by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N3716

Dehydroglyasperin D	Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Aldose Reductase COX
Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC₅₀: 62.4 μM and 176.2 μM respectively). Dehydroglyasperin D has anti-obesity, antioxidant effects. Dehydroglyasperin D shows anti-inflammatory activity by inhibiting COX-2 expression and the MLK3 signaling pathway. Dehydroglyasperin D also inhibits melanin synthesis. Dehydroglyasperin D is a prenylated flavonoid that can be isolated from Glycyrrhiza uralensi .

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MLKs

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