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Mediterranean

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By Targets:	Bacterial (4) Biochemical Assay Reagents (1) E1/E2/E3 Enzyme (1) GSK-3 (1) Herbicide (1) Insecticide (1) NF-κB (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (2) Endocrinology (1) Infection (3) Inflammation/Immunology (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122485

α-Copaene	Bacterial	Infection
α-Copaene is a potent attractant for male Mediterranean fruit flies Ceratitis capitata.α-Copaene can be found as a minor component in the essential oils of various plant species. α-Copaene can inhibit bacterial growth with a minimum inhibitory concentration of 0.5-1 μL/mL. α-Copaene suppresses biofilm formation by decreasing the hydrophobicity of the cell surface. α-Copaene can be used as an oviposition promoter of Bactrocera oleae .

HY-W041608

Methylchloroisothiazolinone	NF-κB Toll-like Receptor (TLR) Bacterial	Infection Inflammation/Immunology
Methylchloroisothiazolinone is a widely used fungicide and also an aquatic pollutant with pro-inflammatory activity and neurotoxicity. Methylchloroisothiazolinone induces the production of pro-inflammatory cytokines (such as IL-1β, TNF-α, IL-6) by activating the NF-κB signaling pathway and upregulating TLR4 expression, thereby triggering allergic contact dermatitis. Methylchloroisothiazolinone reduces cholinesterase activity and exacerbates oxidative stress by impairing catalase activity and disrupting redox balance. Methylchloroisothiazolinone poses significant harm to Mediterranean mussels, reducing the viability of hemocytes and digestive gland cells, inhibiting immune phagocytic function, and disrupting osmoregulatory capacity. Methylchloroisothiazolinone is used in studies on allergic contact dermatitis and related immunotoxicity mechanisms .

HY-W074514

4-Allyltoluene	Insecticide	Others
4-Allyltoluene, an aromatic compound, can elicite antennal olfactory response of Mediterranean fruit fly measured by electroantennography (EAG) .

HY-123888

Viomellein	E1/E2/E3 Enzyme Bacterial	Cancer
Viomellein is a SUMOylation inhibitor with antibacterial and anticancer activities. Viomellein inhibits biofilm formation of strains produced from the fungus Aspergillus ochraceus from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC₅₀ value of 5.0 μM. Viomellein also inhibits SUMOylation of RanGAP1 (GTPase activating protein) with an IC₅₀ of 10.2 μM .

HY-116125

Lignarenone B	GSK-3	Neurological Disease
Lignarenone B is a phenyl conjugated trienone. Lignarenone B can be isolated from the Mediterranean bullomorph Scaphander lignarius. Lignarenone B can inhibit the activity of GSK3β. Lignarenone B can be used in the research of Alzheimer's disease .

HY-N1051

Zarzissine	Bacterial	Infection Cancer
Zarzissine is a cytotoxic guanidine alkaloid that can be isolated from the Mediterranean sponge Anchinoe paupertas. Zarzissine shows antimicrobial and anticancer activities .

HY-N12924

Ethyl 3-octenoate	Others	Endocrinology
Ethyl 3-octenoate is an insect sex pheromone capable of attracting male Mediterranean fruit flies (Ceratitis capitata Wied.) .

HY-116883

Endothion	Biochemical Assay Reagents	Others
Endothion, a systemic insecticide, has been used for agricultural and horticultural areas. Endothion can prevent Mediterranean Drosophila on peaches, and the residual effect lasts for more than 3 weeks without toxicity to leaves and fruits .

HY-121139

Flupropanate 2,2,3,3-Tetrafluoropropionic acid; 3H-Tetrafluoropropionic acid	Herbicide	Others
Flupropanate (2,2,3,3-Tetrafluoropropionic acid; 3H-Tetrafluoropropionic acid) is a soil-active selective herbicide and plant growth inhibitor that acts by inhibiting radicle growth and lipid biosynthesis in sensitive plants. Flupropanate exhibits high-efficiency control of Stipa weeds (such as Nassella neesiana and N. trichotoma) in pastures, and reduces the coverage of the invasive species Eragrostis curvula. Meanwhile, Flupropanate is sensitive to gramineous plants like ryegrass, but shows good selective tolerance to plantain, chicory and some leguminous plants. Studies show that in the protected area with Mediterranean climate in southwestern Australia, Flupropanate produces no significant non-target effects on native plant communities, functional groups or the endangered species Grevillea curviloba, indicating high ecological safety .

Cat. No.	Product Name

HY-L171

Anti-Hematopathy Compound Library	4,172 compounds
Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs. MCE designs a unique collection of 4,172 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

Anti-Hematopathy Compound Library

4,172 compounds

Hematopathy, also known as hematopoietic system diseases, are a class of diseases that hematopoietic system has abnormal changes. Common hematopathy include: aplastic anemia, myeloproliferative diseases, thalassemia, leukemia, lymphoma, myeloma and hemophilia, etc. In recent years, treatments for hematopathy have been developed. In particular, the treatment of malignant hematopathy developed from chemotherapy, radiotherapy, bone marrow development to immunotherapy, induced differentiation therapy, cell therapy, gene therapy and hematopoietic stem cell transplantation. Although these therapies have greatly improved the survival rate of patients, there are still problems such as low cure rate and easy recurrence in the treatment of hematopathy. Therefore, it is of great significance to actively search for new hematopathy therapeutic drugs.

MCE designs a unique collection of 4,172 anti-hematopathy small molecules, which is an effective tool for development and research of anti-hematopathy compounds.

α-Copaene	Structural Classification Natural Products Classification of Application Fields Leguminosae Other Diseases Sindora Plants Disease Research Fields Source Classification	Bacterial
α-Copaene is a potent attractant for male Mediterranean fruit flies Ceratitis capitata.α-Copaene can be found as a minor component in the essential oils of various plant species. α-Copaene can inhibit bacterial growth with a minimum inhibitory concentration of 0.5-1 μL/mL. α-Copaene suppresses biofilm formation by decreasing the hydrophobicity of the cell surface. α-Copaene can be used as an oviposition promoter of Bactrocera oleae .

Viomellein	Microorganisms Phenols Polyphenols Source Classification	E1/E2/E3 Enzyme Bacterial
Viomellein is a SUMOylation inhibitor with antibacterial and anticancer activities. Viomellein inhibits biofilm formation of strains produced from the fungus Aspergillus ochraceus from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC₅₀ value of 5.0 μM. Viomellein also inhibits SUMOylation of RanGAP1 (GTPase activating protein) with an IC₅₀ of 10.2 μM .

Zarzissine	Alkaloids Animals Other Alkaloids Morus alba L. Plants Moraceae Source Classification	Bacterial
Zarzissine is a cytotoxic guanidine alkaloid that can be isolated from the Mediterranean sponge Anchinoe paupertas. Zarzissine shows antimicrobial and anticancer activities .

Ethyl 3-octenoate	Natural Products Animals Source Classification	Others
Ethyl 3-octenoate is an insect sex pheromone capable of attracting male Mediterranean fruit flies (Ceratitis capitata Wied.) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Mediterranean

Inhibitors & Agonists

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