2. Search Result
Search Result
Results for "

Meropenem

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

2

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13678
    Meropenem
    30+ Cited Publications

    SM 7338

    		 Penicillin-binding protein (PBP) Bacterial Antibiotic Infection Cancer
    Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem
  • HY-13678A
    Meropenem trihydrate
    Maximum Cited Publications
    32 Publications Verification

    SM 7338 trihydrate

    		 Penicillin-binding protein (PBP) Bacterial Antibiotic Infection Cancer
    Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem trihydrate
  • HY-13678S
    Meropenem-d6

    SM 7338-d6

    		 Bacterial Antibiotic Infection
    Meropenem-d6 is the deuterium labeled Meropenem. Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem-d6
  • HY-109008
    Nacubactam
    2 Publications Verification

    OP0595 free acid

    		 Beta-lactamase Bacterial Infection
    Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae .
    Nacubactam
  • HY-111521
    Meropenem-vaborbactam

    Carbavance

    		 Antibiotic Bacterial Beta-lactamase Infection
    Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL .
    Meropenem-vaborbactam
  • HY-13678AR
    Meropenem trihydrate (Standard)

    SM 7338 trihydrate (Standard)

    		 Penicillin-binding protein (PBP) Reference Standards Bacterial Antibiotic Infection Cancer
    Meropenem (trihydrate) (Standard) is the analytical standard of Meropenem (trihydrate). This product is intended for research and analytical applications. Meropenem trihydrate (SM 7338 trihydrate) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem trihydrate has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem trihydrate (Standard)
  • HY-N12763
    Sodium new houttuyfonate

    SNH

    		 Bacterial Renin Inflammation/Immunology
    Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC50 of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .
    Sodium new houttuyfonate
  • HY-125604
    WCK-4234

    		Beta-lactamase Bacterial Infection Inflammation/Immunology
    WCK-4234 is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 lacks direct antibacterial activity. WCK-4234 inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .
    WCK-4234
  • HY-178019
    NDM-1-IN-10

    		Beta-lactamase Bacterial Infection
    NDM-1-IN-10 (Compound CS-23) is an irreversible and covalent New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 36  nM. NDM-1-IN-10 shows a synergistic effect with Meropenem (HY-13678) against NDM-1-expressing E. coli ( MIC of 0.25 μg/mL for E. coli BL21/pET15b-blaNDM-1). NDM-1-IN-10 can be used for bacterial infections research .
    NDM-1-IN-10
  • HY-178976
    YL6113

    		Beta-lactamase Infection
    YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection .
    YL6113
  • HY-117951
    ANT431

    		Beta-lactamase Infection
    ANT431 is a metallo-β-lactamase inhibitor that also restores the effectiveness of Meropenem (HY-13678) in a mouse thigh Escherichia coli infection model .
    ANT431
  • HY-163191
    NDM-1 inhibitor-5

    		Beta-lactamase Bacterial Infection
    NDM-1 inhibitor-5 (compound 57) is a potent NDM-1 inhibitor, with a Ki of 2.5 μM. NDM-1 inhibitor-5 also shows antibacterial synergistic activity with meropenem (HY-13678) .
    NDM-1 inhibitor-5
  • HY-176519
    ANT2681

    		Beta-lactamase Bacterial Infection
    ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae .
    ANT2681
  • HY-P5704
    K11

    		Bacterial Infection
    K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .
    K11
  • HY-W740053
    Meropenem sodium

    		Penicillin-binding protein (PBP) Bacterial Antibiotic Infection Cancer
    Meropenem sodium is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem sodium has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL) .
    Meropenem sodium
  • HY-171112
    KSP-1007

    		Beta-lactamase Bacterial Infection
    KSP-1007 is a bicyclic boronate-based broad-spectrum β-lactamase inhibitor. KSP-1007 can effectively inhibit class A, B, C and D β-lactamases, including serine-type, metallo-type (such as NDM, VIM, IMP) and Acinetobacter baumannii OXA-type enzymes. KSP-1007 can enhance the antibacterial activity of Meropenem (HY-13678), reduce its MIC value, and be effective against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. KSP-1007 can be used for the research of bacterial infection .
    KSP-1007
  • HY-143415
    Metallo-β-lactamase-IN-7

    		Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains .
    Metallo-β-lactamase-IN-7
  • HY-143414
    Metallo-β-lactamase-IN-6

    		Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL .
    Metallo-β-lactamase-IN-6
  • HY-163906
    Anti-MRSA agent 16

    		Bacterial Infection
    Anti-MRSA agent 16 (Compound 4) is an inhibitor of methicillin-resistant Staphylococcus aureus (MRSA). Anti-MRSA agent 16 is effective in combination with oxacillin or meropenem in infected mice .
    Anti-MRSA agent 16
  • HY-W743988
    Cilastatin ammonium salt

    		Antibiotic Bacterial Infection
    Cilastatin ammonium salt is an antibiotic that is relatively effective against Gram-positive cocci with a half-life of 3-4 h .
    Cilastatin ammonium salt
  • HY-P11182
    ChMAP-28

    		Bacterial Infection Cancer
    ChMAP-28 is an antimicrobial peptide. ChMAP-28 can be derived from goat Capra hircus. ChMAP-28 can initiate necrotic death. ChMAP-28 is effective in killing many bacteria, including strains resistant to Polymyxin and Meropenem (HY-13678). ChMAP-28 shows antitumor activity against acute promyelocytic leukemia, epidermoid carcinoma, melanoma, breast adenocarcinoma .
    ChMAP-28
  • HY-120235
    CB-618

    		Beta-lactamase Bacterial Infection
    CB-618 is a β-lactamase inhibitor. CB-618 reversibly covalently inhibits Ambler class A, C, and some class D serine β-lactamases. CB-618 has weak antibacterial activity as a single agent, but it significantly enhances the antibacterial activity of Meropenem (HY-13678) against enzyme-producing Enterobacteriaceae. CB-618 can be used in research on drug-resistant bacteria .
    CB-618
  • HY-162493
    MBL-IN-3

    		Bacterial Infection
    MBL-IN-3 (compound 72922413) is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor(IC50=54±4 μM). MBL-IN-3 is identified and shown to lower minimum inhibitory concentrations (MICs) of Meropenem (HY-13678) for a panel of E. coli and K. pneumoniae clinical isolates expressing NDM-1. MBL-IN-3 can be used for antibiotic sensitizer research .
    MBL-IN-3
  • HY-168861
    NDM-1 inhibitor-8

    		Beta-lactamase Bacterial Infection
    NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC50 of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models .
    NDM-1 inhibitor-8
  • HY-174980
    KPC-2-IN-3

    		Bacterial Infection
    KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with IC50 of 0.533  μM and Kiof 0.194  μM. KPC-2-IN-3 has an antimicrobial activity against carbapenem-resistant K. pneumonia K47-25 and reduces bacterial count with a postantibiotic effect in synergy with Meropenem (HY-13678). KPC-2-IN-3 significantly reduces lung bacterial load in a murine pneumonia model .
    KPC-2-IN-3
  • HY-118013
    NDM-1 inhibitor-2

    		Bacterial Infection
    NDM-1 inhibitor-2 is an inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) and has the ability to inhibit NDM-1 activity. NDM-1 inhibitor-2 exhibits a good inhibitory effect on drug-resistant bacterial strains that overexpress NDM-1. When NDM-1 inhibitor-2 is used in combination with the carbapenem antibiotic meropenem, a favorable synergistic effect can be produced .
    NDM-1 inhibitor-2
  • HY-150260
    SA09-Cu

    		Bacterial Infection
    SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .
    SA09-Cu
  • HY-164611
    ZM 213689

    		Drug Metabolite Endocrinology
    ZM 213689 is a major metabolite of Meropenem (HY-13678), and it can be detected in both plasma and urine .
    ZM 213689
  • HY-P11720
    M104 peptide

    		Beta-lactamase Bacterial Infection
    M104 peptide is an OXA-48 carbapenemase inhibitor and antibiotic potentiator. M104 peptide effectively blocks the binding and active site cavity of OXA-48 . M104 peptide restores Meropenem (HY-13678)’s antibacterial activity against OXA-48-producing Klebsiella pneumoniae. M104 peptide can be used for the research of Carbapenem-resistant Klebsiella pneumoniae infection .
    M104 peptide
  • HY-122262
    NDM-1-IN-6

    		Beta-lactamase Bacterial Infection
    NDM-1-IN-6 (Compound 1) is a potent, selective and competitive New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor with a Ki of 0.72 μM. NDM-1-IN-6 has a synergistic antibacterial effect with the carbapenem antibiotic Meropenem (HY-13678). NDM-1-IN-6 is mainly used for research on NDM-1-mediated multidrug-resistant bacterial infections .
    NDM-1-IN-6
  • HY-179618
    NDM-1-IN-11

    		Beta-lactamase Bacterial Infection
    NDM-1-IN-11 is a potent covalent NDM-1 inhibitor with an IC50 of 1.12 μM, which acts by forming a Se-S bond with the enzyme. NDM-1-IN-11 effectively suppresses the growth of NDM-1-producing E. coli in both in vivo and in vitro models when combined with Meropenem (HY-13678). NDM-1-IN-11 can be used for addressing NDM-1 driven bacterial resistance .
    NDM-1-IN-11
  • HY-125604A
    WCK-4234 free base

    		Beta-lactamase Bacterial Infection Inflammation/Immunology
    WCK-4234 free base is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 free base lacks direct antibacterial activity. WCK-4234 free base inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 free base can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections .
    WCK-4234 free base
  • HY-109008R
    Nacubactam (Standard)

    OP0595 free acid (Standard)

    		 Beta-lactamase Reference Standards Bacterial Infection
    Nacubactam (Standard) is the analytical standard of Nacubactam (HY-109008). This product is intended for research and analytical applications. Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae .
    Nacubactam (Standard)

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: