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Results for "

N-methyl-N'-dodecylguanidine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADC Linker (1) Amino Acid Derivatives (2) Bacterial (3) Biochemical Assay Reagents (7) CD38 (1) Cholecystokinin Receptor (1) CRFR (2) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Intermediate (3) Endogenous Metabolite (3) Ferroportin (1) Herbicide (1) Isotope-Labeled Compounds (12) Macrophage migration inhibitory factor (MIF) (1) MMP (1) MOFs (1) Nucleoside Antimetabolite/Analog (1) PROTAC Linkers (13) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Ser/Thr Protease (2) Serotonin Transporter (1) Vasopressin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (19) Infection (6) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (4)
Click Chemistry:	PROTAC Synthesis (7) Azide (4) Alkynes (3)
Oligonucleotides:	Nucleoside Analogs (1) Uridine (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-W089645

*2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide* 1 Publications Verification N-methyl-n-trimethylsilyltrifluoroacetamide	Biochemical Assay Reagents	Cancer
2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide (N-Methyl-n-trimethylsilyltrifluoroacetamide) is an ester product commonly used for silylation reactions in analyticalchemistry. 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide can be used in the derivatization step of metabolomics analysis with gas chromatography/mass spectrometry (GC/MS) or as a derivatization reagent in GC with flame ionization detection analysis. 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide can be used in research for studying Tamoxifen (HY-13757A) resistant breast cancer cells and other disease pathways .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-127034

Antipain dihydrochloride	Ser/Thr Protease DNA/RNA Synthesis	Metabolic Disease Cancer
Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Endogenous Metabolite	Others
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

HY-40352

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Drug Intermediate	Others
N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a drug intermediate for synthesis of various active compounds.

HY-40352B

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride	Drug Intermediate	Others
N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride is a drug intermediate for synthesis of various active compounds.

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-Z0085

*2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide*	Drug Intermediate	Others
2-Chloro-N-methyl-N-(4-nitrophenyl)acetamide is a synthetic intermediate useful for pharmaceutical synthesis.

HY-118796

4-Hydroxy MET 4-HO-MET; 4-Hydroxy-N-methyl-N-ethyltryptamine	5-HT Receptor Serotonin Transporter	Neurological Disease
4-Hydroxy MET (4-HO-MET; 4-Hydroxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine psychoactive substance. 4-Hydroxy MET is a partial 5-HT2A receptor agonist, a serotonin transporter inhibitor and weak norepinephrine transporter inhibitor. 4-Hydroxy MET affects emotional, motoric, and cognitive functions via serotonergic hallucinogenic activity .

HY-149308

MKA031	Macrophage migration inhibitory factor (MIF)	Infection
MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC₅₀ value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection .

HY-153059

*5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine*	Nucleoside Antimetabolite/Analog	Others
5-(N-Methyl-N-trifluoroacetyl)aminomethyl uridine is a nucleoside compound .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-W663740

*1-Methyl-4-nitrosopiperazine* MNP; MeNP; N-methyl-N'-nitrosopiperazine	Biochemical Assay Reagents	Others
1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-W198256

*Tert-butyl n-methyl-N-[2-(piperidin-4-yl)ethyl]carbamate*	PROTAC Linkers	Cancer
Tert-butyl n-methyl-N-[2-(piperidin-4-yl)ethyl]carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-127039

Antipain	Ser/Thr Protease DNA/RNA Synthesis	Metabolic Disease Cancer
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice .

HY-143822S

N-Methyl-N’-nitrosopiperazine-d4	Isotope-Labeled Compounds	Others
N-Methyl-N’-nitrosopiperazine-d₄ is the deuterium labeled N-Methyl-N’-nitrosopiperazine .

HY-111054

N-methyl-N-dithiocarboxyglucamine MDCG	Endogenous Metabolite	Inflammation/Immunology
N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound ¹⁰⁹Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication .

HY-Y0544S

N-Methyl-N-nitrosotoluene-4-sulfonamide-d3	Isotope-Labeled Compounds	Others
N-Methyl-N-nitrosotoluene-4-sulfonamide-d₃ is the deuterium labeled N-Methyl-N-nitrosotoluene-4-sulfonamide .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-170475

5-MeO-MET 5-Methoxy-N-methyl-N-ethyltryptamine	5-HT Receptor	Neurological Disease
5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) is a 5-methoxytryptamines compound. 5-MeO-MET is the agonist of 5-HT_1A and 5-HT_2A. 5-MeO-MET can inhibit the movement of mice and has a sedative effect .

HY-W613883

*tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate*	PROTAC Linkers	Cancer
tert-Butyl N-methyl-N-[4-(methylamino)butyl]carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-W250410

N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine	ADC Linker	Cancer
N-Methyl-N-[(3-methyldithio)-1-oxopropyl]-L-alanine is a PEGn linker for antibody-drug-conjugation (ADC).

HY-W704014

*N-Nitroso-N-methyl-N-dodecylamine-d5* N-methyl-N-nitroso-1-dodecanamine-d₅	Isotope-Labeled Compounds	Others
N-Nitroso-N-methyl-N-dodecylamine-d₅ (N-Methyl-N-nitroso-1-dodecanamine-d₅) is the deuterium labeled N-Methyl-N-nitroso-1-dodecanamine (HY-W899995).

HY-W089645S

N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d9	Isotope-Labeled Compounds	Others
N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d₉ is the deuterium labeled N-Methyl-N-(trimethylsilyl)trifluoroacetamide .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-W725046

N-Methyl-N-phenylnitrous amide-d5	Isotope-Labeled Compounds	Others
N-Methyl-N-phenylnitrous amide-d₅ is the deuterium labeled N-Methyl-N-phenylnitrous amide (HY-W015813).

HY-W047901

N-Methyl-N-phenylglycine	Amino Acid Derivatives	Others
N-Methyl-N-phenylglycine is a Glycine (HY-Y0966) derivative .

HY-W665796

N-Methyl-N-nitroso-2-propanamine	Drug Derivative	Cancer
N-Methyl-N-nitroso-2-propanamine is an N-nitrosamine, which induces tumor formation in mice .

HY-W015813S

N-Methyl-N-phenylnitrous amide-13C,d3,15N	Isotope-Labeled Compounds	Others
N-Methyl-N-phenylnitrous amide- ¹³C,d₃, ¹⁵N is the deuterium, ¹³C and ¹⁵N labeled N-Methyl-N-phenylnitrous amide .

HY-140510

N-Methyl-N-(t-Boc)-PEG4-acid	PROTAC Linkers	Cancer
N-Methyl-N-(t-Boc)-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141049

N-methyl-N'-(propargyl-PEG4)-Cy5	PROTAC Linkers	Cancer
N-methyl-N'-(propargyl-PEG4)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-59252

*tert-Butyl N-methyl-N-(piperidin-4-ylmethyl)carbamate*	PROTAC Linkers	Cancer
tert-Butyl N-methyl-N-(piperidin-4-ylmethyl)carbamate is a PROTAC linker that can be used in the synthesis of PROTACs.

HY-141072

N-Methyl-N'-(hydroxy-PEG2)-Cy5	PROTAC Linkers	Cancer
N-Methyl-N'-(hydroxy-PEG2)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140010

N-methyl-N'-(azide-PEG3)-Cy3	PROTAC Linkers	Cancer
N-methyl-N'-(azide-PEG3)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-(azide-PEG3)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141062

N-Methyl-N'-(azido-PEG2-C5)-Cy5	PROTAC Linkers	Cancer
N-Methyl-N'-(azido-PEG2-C5)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-Methyl-N'-(azido-PEG2-C5)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141040

N-methyl-N'-methyl-O-(m-PEG4)-O'-(acid-PEG5)-Cy5	PROTAC Linkers	Cancer
N-methyl-N'-methyl-O-(m-PEG4)-O'-(acid-PEG5)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141032

N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3	PROTAC Linkers	Cancer
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141052

N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5	PROTAC Linkers	Cancer
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141067

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5	PROTAC Linkers	Cancer
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141031

N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3	PROTAC Linkers	Cancer
N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W702094

N-Methyl-N-(3-oxopropyl)nitrous amide-d5	Isotope-Labeled Compounds	Others
N-Methyl-N-(3-oxopropyl)nitrous amide-d₅ is the deuterium labeled N-Methyl-N-(3-oxopropyl)nitrous amide (HY-W701813).

HY-79417

*(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide* Carbamic acid, [(1S)-1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester (9CI); Carbamic acid, [1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester, (S)-	Amino Acid Derivatives	Others
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide is a leucine derivative .

HY-W076490

Defenuron IPO 4328; N-methyl-N'-phenylurea; 1-methyl-3-phenylurea	Herbicide	Others
Defenuron (IPO 4328) is a herbicide for controlling undesirable grasses and broad-leaved plants in a variety of crops .

HY-W074886

N-Methyl-N-tetradecanoylglycine	Biochemical Assay Reagents	Others
N-Methyl-N-tetradecanoylglycine is a rectal absorption promoter. N-Methyl-N-tetradecanoylglycine enhances rectal absorption of antibiotics .

HY-40352R

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (Standard)	Reference Standards
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (Standard) is the analytical standard of N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. This product is intended for research and analytical applications.

Cat. No.	Product Name	Target	Research Area

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-P10272

Rusfertide PTG-300	Ferroportin	Others
Rusfertide is a peptide mimetic of natural hepcidin, which targets and degrades ferroportin, reduces serum iron and transferrin-saturation, and thus regulates the production of red blood cells. Rusfertide ameliorates the polycythemia vera, β-thalassemia and hereditary hemochromatosis .

HY-A0248A

Polymyxin B1 1 Publications Verification	Bacterial	Infection
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P10143

MMP-2/MMP-9 Substrate Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt	MMP	Others
MMP-2/MMP-9 Substrate (Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt) is a synthetic chromogenic polypeptide substrate whose core structure mimics the cleavage sites of MMP-2 and MMP-9 (gelatinase A and B) in collagen. After being hydrolyzed by collagenase, MMP-2/MMP-9 Substrate reacts with 4,4'-dithiodipyridine or Ellman's Reagent via its thiol fragment to produce a product with ultraviolet absorption properties .

HY-A0248AS

Polymyxin B1-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

HY-P10828

MAPI	Virus Protease	Infection Inflammation/Immunology
MAPI is a polypeptide irreversible 3C cysteine protease (SV3CP) inhibitor. MAPI inhibits SV3CP by covalently binding its C-terminal Michael-acceptor extension to the active site thiol of SV3CP Cys 139. MAPI is promising for research of noroviruses infection .

HY-W047901

N-Methyl-N-phenylglycine	Amino Acid Derivatives	Others
N-Methyl-N-phenylglycine is a Glycine (HY-Y0966) derivative .

HY-79417

*(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide* Carbamic acid, [(1S)-1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester (9CI); Carbamic acid, [1-[(methoxymethylamino)carbonyl]-3-methylbutyl]-, 1,1-dimethylethyl ester, (S)-	Amino Acid Derivatives	Others
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide is a leucine derivative .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2592

Ro 23-7014	Cholecystokinin Receptor	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-125628

Kahalalide A	Endogenous Metabolite	Infection
Kahalalide A is an anti-mycobacterial compound with antimicrobial activity. Kahalalide A is derived from the marine mollusk Elysia rufescens. Kahalalide A has attracted extensive attention in natural product research due to its potential medicinal value .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Isotope-Labeled Compounds Bacterial	Infection
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-111054A

N-methyl-N-dithiocarboxyglucamine sodium MDCG sodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound ¹⁰⁹Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity .

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-111054

N-methyl-N-dithiocarboxyglucamine MDCG	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
N-methyl-N-dithiocarboxyglucamine (MDCG) mobilizes and promotes excretion of metallothione-bound ¹⁰⁹Cd. N-methyl-N-dithiocarboxyglucamine shows effects on acute and chronic Cd intoxication .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Chemical Structure

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-143822S

N-Methyl-N’-nitrosopiperazine-d4
N-Methyl-N’-nitrosopiperazine-d₄ is the deuterium labeled N-Methyl-N’-nitrosopiperazine .

HY-Y0544S

N-Methyl-N-nitrosotoluene-4-sulfonamide-d3
N-Methyl-N-nitrosotoluene-4-sulfonamide-d₃ is the deuterium labeled N-Methyl-N-nitrosotoluene-4-sulfonamide .

HY-W704014

*N-Nitroso-N-methyl-N-dodecylamine-d5*
N-Nitroso-N-methyl-N-dodecylamine-d₅ (N-Methyl-N-nitroso-1-dodecanamine-d₅) is the deuterium labeled N-Methyl-N-nitroso-1-dodecanamine (HY-W899995).

HY-W089645S

N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d9
N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d₉ is the deuterium labeled N-Methyl-N-(trimethylsilyl)trifluoroacetamide .

HY-W725046

N-Methyl-N-phenylnitrous amide-d5
N-Methyl-N-phenylnitrous amide-d₅ is the deuterium labeled N-Methyl-N-phenylnitrous amide (HY-W015813).

HY-W015813S

N-Methyl-N-phenylnitrous amide-13C,d3,15N
N-Methyl-N-phenylnitrous amide- ¹³C,d₃, ¹⁵N is the deuterium, ¹³C and ¹⁵N labeled N-Methyl-N-phenylnitrous amide .

HY-W702094

N-Methyl-N-(3-oxopropyl)nitrous amide-d5
N-Methyl-N-(3-oxopropyl)nitrous amide-d₅ is the deuterium labeled N-Methyl-N-(3-oxopropyl)nitrous amide (HY-W701813).

HY-W700581

*1-(Methyl-d3)-4-nitrosopiperazine*
1-(Methyl-d₃)-4-nitrosopiperazine is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-W726845

*1-Methyl-4-nitrosopiperazine-d11*
1-Methyl-4-nitrosopiperazine-d₁₁ (MNP-d₁₁) is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-W416548S

*1-Methyl-4-nitro piperazine-d11*
1-Methyl-4-nitro piperazine-d₁₁ is the deuterium labeled 1-Methyl-4-nitro piperazine. 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA

Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name		Classification

HY-141049

N-methyl-N'-(propargyl-PEG4)-Cy5		PROTAC Synthesis Alkynes
N-methyl-N'-(propargyl-PEG4)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-140010

N-methyl-N'-(azide-PEG3)-Cy3		Azide PROTAC Synthesis
N-methyl-N'-(azide-PEG3)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-(azide-PEG3)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141062

N-Methyl-N'-(azido-PEG2-C5)-Cy5		PROTAC Synthesis Azide
N-Methyl-N'-(azido-PEG2-C5)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-Methyl-N'-(azido-PEG2-C5)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141032

N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3		PROTAC Synthesis Alkynes
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141052

N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5		PROTAC Synthesis Alkynes
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141067

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5		PROTAC Synthesis Azide
N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-141031

N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3		Azide PROTAC Synthesis
N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-Methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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