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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
Non-catalytic
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "Non-catalytic" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-18595
CAS No.: 1155419-89-8
Target:
Research Areas:
BI 224436 is a novel HIV-1 noncatalytic site integrase inhibitor with EC50 values of less than 15 nM against different HIV-1 laboratory strains.
3
3 Cited Publications
Target:
Research Areas:
JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide. JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1.4 µM). JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion. JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase .
2
2 Cited Publications
Cat. No.: HY-P76141
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit; Protein Kinase AMP-Activated Non-catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein Kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein Kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Human
Source:
Sf9 insect cells
2
2 Cited Publications
Cat. No.: HY-P76143
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit; Protein Kinase AMP-Activated Non-catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein Kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein Kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Human
Source:
Sf9 insect cells
Category:
Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology
Target:
Cat. No.: HY-162362
CAS No.: 3060730-06-2
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Research Areas:
MS8709 is a PROTAC degrader that induces the degradation of G9a (EHMT2)/GLP (EHMT1) by recruiting VHL. MS8709 induces G9a/GLP protein degradation via a mechanism that simultaneously depends on G9a/GLP target protein binding, VHL recruitment, and the ubiquitin-proteasome system (UPS), while the mRNA levels of G9a and GLP do not show significant changes, indicating that the effect occurs primarily at the protein level rather than the transcriptional level. MS8709 retains the inhibitory effect on G9a/GLP methyltransferase activity and reduces H3K9me2 levels, thereby simultaneously affecting the catalytic and non-catalytic functions of G9a/GLP. MS8709 can be used for studies related to G9a/GLP biology, prostate cancer, lung cancer, and other relevant fields .
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EN523 is a OTUB1 recruiter. EN523 targets a non-catalytic allosteric cysteine C23 in the K48-ubiquitin-specific deubiquitinase OTUB1 .
Cat. No.: HY-163144
CAS No.: 3044084-97-8
DAS-5-oCRBN is a PROTAC molecule with both c‑Src kinase inhibitory activity and target protein degradation activity, with an EC50 of 45 nM for c‑Src binding. DAS-5-oCRBN binds non-covalently to Cereblon and mediates target protein degradation via the ubiquitin-proteasome pathway. DAS-5-oCRBN can catalytically deplete intracellular c‑Src protein, while blocking both the kinase catalytic function of c‑Src and the non-catalytic protein interactions mediated by its SH2 and SH3 domains. DAS-5-oCRBN inhibits tumor cell proliferation and exerts significant anti-proliferative effects on both c‑Src kinase activity-dependent MDA-MB-231 cells and c‑Src protein level-dependent CAL51 cells. DAS-5-oCRBN can be used in cancer-related research such as studies on triple-negative breast cancer and chronic myeloid leukemia .
Cat. No.: HY-179157
Research Areas:
MA203 is a selective CHK1 PROTAC degrader. MA203 targets activated CHK1 for degradation by recruiting the CRBN E3 ubiquitin ligase, thereby completely abolishing both its catalytic and non-catalytic functions and ultimately triggering DNA replication catastrophe and apoptosis. MA203 can be used in research related to pancreatic ductal adenocarcinoma, colorectal cancer, and acute lymphoblastic leukemia .
Cat. No.: HY-113357R
CAS No.: 588-30-7
Cat. No.: HY-158038
CAS No.: 3035323-39-5
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Research Areas:
AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA .
Cat. No.: HY-160550
CAS No.: 3018836-86-4
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Research Areas:
DPM-1003 is a modulator of protein tyrosine phosphatase 1B (PTP1B) and C-X-C chemokine receptor 4 (CXCR4). DPM-1003 binds to the non-catalytic disordered C-terminal fragment of PTP1B. DPM-1003 inhibits the PI3Kγ-mediated AKT/mTOR signaling pathway downstream of CXCR4. DPM-1003 improves the survival rate of mice in a transfusion-related acute lung injury model, and exerts a lung injury protective effect in preclinical mouse models of acute lung injury and sepsis. DPM-1003 can be used in research related to acute lung injury, acute respiratory distress syndrome, transfusion-related acute lung injury and sepsis .
Cat. No.: HY-123564
CAS No.: 2012563-34-5
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Research Areas:
Mcl1-IN-7 (compound 11) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. By covalently targeting the non-catalytic lysine side chain of Mcl-1, it has higher potency than non-covalent counterparts and can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.
Cat. No.: HY-116220
CAS No.: 2012563-29-8
Mcl1-IN-14 (compound 5) is a reversible covalent inhibitor of Mcl-1 with the activity of inhibiting Mcl-1. Mcl1-IN-14 covalently targets the non-catalytic lysine side chain of Mcl-1 and has higher potency than non-covalent counterparts, which can be used to develop Mcl-1 inhibitory compounds and study related biological phenomena.
Cat. No.: HY-W339645
CAS No.: 31220-35-6
Synonyms: (S)-Naproxen ethyl ester
Target:
Research Areas:
Naproxen ethyl ester ((S)-Naproxen ethyl ester) is a nonsteroidal anti-inflammatory drug with activity in relieving pain, fever, swelling and stiffness. Naproxen ethyl ester exerts its effects by inhibiting non-selective cyclooxygenase (COX). The R-(-)-isomer of Naproxen ethyl ester shows stronger immunogenicity, and the Michaelis-Menten parameter of its catalytic reaction is K(M)=6.67 mM, and the catalytic efficiency is 5.8 x 10^4 times higher than that of the non-catalytic reaction .
Cat. No.: HY-P75701
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: DDOST; Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit (Non-catalytic); Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-catalytic Subunit; Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase; OST48; Doli
Species:
Human
Source:
E. coli
Cat. No.: HY-12135
CAS No.: 1239513-63-3
Target:
Research Areas:
Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research .
Cat. No.: HY-P703633
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: METTL14; Methyltransferase Like 14; Methyltransferase 14, N6-Adenosine-Methyltransferase Non-catalytic Subunit; HMETTL14; N(6)-Adenosine-Methyltransferase Non-catalytic Subunit METTL14; Methyltransferase 14, N6-Adenosine-Methyltransferase Complex Catalyti
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705610
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: N(6)-adenosine-methyltransferase Non-catalytic subunit METTL14; Methyltransferase-like protein 14; hMETTL14; METTL14; KIAA1627
Species:
Human
Source:
E. coli
Cat. No.: HY-P77693Y
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Serine protease hepsin; EC:3.4.21.106; Transmembrane protease serine 1; Serine protease hepsin Non-catalytic chain; Serine protease hepsin catalytic chain; HPN; TMPRSS1
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
