Search Result
Results for "
Norbornene
" in MedChemExpress (MCE) Product Catalog:
8
Biochemical Assay Reagents
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W440896
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Liposome
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Others
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DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
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- HY-W013021
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Ligands for E3 Ligase
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Others
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Norbornene is a cycloolefin and building block for synthesis of porous organic polymeric materials via metathesis, addition, and CANAL polymerization. Norbornene can also be used as an E3 ligase ligand for the synthesis of PROTAC, such as PROTAC HyTTD Degrader-1 (HY-181895) .
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- HY-151727
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ADC Linker
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Others
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Norbornene-NHS is a norbornene-functionalized antibody-drug conjugate linker (ADC Linker) bearing an NHS ester, which is applicable for highly efficient and specific antibody conjugation reactions in ADC research and development. Norbornene-NHS also acts as an azide-group-containing click chemistry reagent, serving as a dienophile for copper-free click reaction conjugation .
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- HY-152246
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DNA/RNA Synthesis
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Cancer
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ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research .
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- HY-151742
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ADC Linker
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Others
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Norbornene-methyl-NHS is a norbornene-based antibody-drug conjugate linker (ADC Linker) bearing methyl and NHS ester functional groups, which can be used for specific antibody conjugation. Norbornene-methyl-NHS is also a click chemistry reagent containing a TCO group, acting as a dienophile for conjugation via the Diels-Alder reaction, namely the copper-free click reaction with tetrazine .
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- HY-151682
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Amino Acid Derivatives
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Others
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H-L-Lys(Norbornene-methoxycarbonyl)-OH is a Norbornene (HY-W013021)-derivatized lysine that can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-128478
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Fungal
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Infection
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Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .
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- HY-W013021R
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Others
Reference Standards
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Others
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Norbornene (Standard) is the analytical standard of Norbornene (HY-W013021). This product is intended for research and analytical applications. Norbornene is a bicyclic compound. Norbornene polymers can be used in tissue engineering and drug release system .
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- HY-W1048695E
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Biochemical Assay Reagents
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Others
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4-Arm-PEG2000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG2000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG2000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-W1048695A
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Biochemical Assay Reagents
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Others
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4-Arm-PEG5000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG5000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG5000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-182840A
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Biochemical Assay Reagents
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Others
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8-Arm-PEG20000-Norbornene is a eight-armed PEG derivative. The core structure of 8-Arm-PEG20000-Norbornene consists of eight PEG chains, each modified at the end with norbornene molecules. 8-Arm-PEG20000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-182840
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Biochemical Assay Reagents
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Others
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8-Arm-PEG10000-Norbornene is a eight-armed PEG derivative. The core structure of 8-Arm-PEG10000-Norbornene consists of eight PEG chains, each modified at the end with norbornene molecules. 8-Arm-PEG10000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-W1048695C
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Biochemical Assay Reagents
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Others
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4-Arm-PEG20000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG20000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG20000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-182840B
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Biochemical Assay Reagents
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Others
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8-Arm-PEG40000-Norbornene is a eight-armed PEG derivative. The core structure of 8-Arm-PEG40000-Norbornene consists of eight PEG chains, each modified at the end with norbornene molecules. 8-Arm-PEG40000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-W1048695B
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Biochemical Assay Reagents
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Others
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4-Arm-PEG10000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG10000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG10000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-W022007
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JBP
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Ligands for E3 Ligase
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Others
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5-Norbornene-2-methylamine (JBP) is a hydrophobic tag. 5-Norbornene-2-methylamine can be used for the synthesis of HyT degraders, such as PARP1 degrader-2 (HY-181460) .
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- HY-181908
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HyT
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Inflammation/Immunology
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5-Norbornene-2-methylamine-C10-NH2 is a Keap1-targeting hydrophobic tag (HyT)-linker conjugates, containing a HyT (HY-W022007) and a linker (HY-W014831). 5-Norbornene-2-methylamine-C10-NH2 can be used for synthesis of NBE5 (HY-181907) .
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- HY-D2957
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NorBG; SNAP-Nor
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Drug Derivative
Nucleoside Antimetabolite/Analog
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Others
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BG-Nor (NorBG) is a Benzylguanine analogue containing Norbornene (HY-W013021). BG-Nor can be converted by cell surface SNAP tags. NorBG can be used for tetrazine-linked labeling of cells via the iEDDA reaction .
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- HY-182057
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HyT
Anaplastic lymphoma kinase (ALK)
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Cancer
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ALK degrader 4 is a ALK HyT degrader with an IC50 of 0.74 nM. ALK degrader 4 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK degrader 4 inhibits cancer cell proliferation. ALK degrader 4 can be used in research related to non-small cell lung cancer (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Norbornene (HY-W013021)) .
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- HY-186171
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Biochemical Assay Reagents
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Others
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Mal-(1R,2S,3R,4S)-himic acid-alkyne is a trifunctional click chemistry scaffold containing complementary functionalities for copper catalyzed azide-alkyne (CuAAC), thiol-Michael addition, and inverse electron demand Diels-Alder (iEDDA) click reactions .
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- HY-W422109
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Drug Derivative
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Others
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4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid is an asymmetric tetrazine derivative and a bioorthogonal reaction partner. 4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid can be conjugated with Bevacizumab (HY-P9906) via EDC/NHS activation while retaining the VEGF-binding affinity of the antibody, thus constructing a targeting agent for pretargeted immuno-PET/NIRF imaging .
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| Cat. No. |
Product Name |
Type |
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- HY-D2957
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NorBG; SNAP-Nor
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Fluorescent Dyes
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BG-Nor (NorBG) is a Benzylguanine analogue containing Norbornene (HY-W013021). BG-Nor can be converted by cell surface SNAP tags. NorBG can be used for tetrazine-linked labeling of cells via the iEDDA reaction .
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| Cat. No. |
Product Name |
Type |
-
- HY-W440896
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
|
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- HY-W1048695E
-
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Biochemical Assay Reagents
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4-Arm-PEG2000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG2000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG2000-Norbornene can be used for bioconjugation and drug delivery.
|
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- HY-W1048695A
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG5000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG5000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG5000-Norbornene can be used for bioconjugation and drug delivery.
|
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- HY-182840A
-
|
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Biochemical Assay Reagents
|
|
8-Arm-PEG20000-Norbornene is a eight-armed PEG derivative. The core structure of 8-Arm-PEG20000-Norbornene consists of eight PEG chains, each modified at the end with norbornene molecules. 8-Arm-PEG20000-Norbornene can be used for bioconjugation and drug delivery.
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- HY-182840
-
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Biochemical Assay Reagents
|
|
8-Arm-PEG10000-Norbornene is a eight-armed PEG derivative. The core structure of 8-Arm-PEG10000-Norbornene consists of eight PEG chains, each modified at the end with norbornene molecules. 8-Arm-PEG10000-Norbornene can be used for bioconjugation and drug delivery.
|
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- HY-W1048695C
-
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Biochemical Assay Reagents
|
|
4-Arm-PEG20000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG20000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG20000-Norbornene can be used for bioconjugation and drug delivery.
|
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- HY-182840B
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Biochemical Assay Reagents
|
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8-Arm-PEG40000-Norbornene is a eight-armed PEG derivative. The core structure of 8-Arm-PEG40000-Norbornene consists of eight PEG chains, each modified at the end with norbornene molecules. 8-Arm-PEG40000-Norbornene can be used for bioconjugation and drug delivery.
|
-
- HY-W1048695B
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG10000-Norbornene is a four-armed PEG derivative. The core structure of 4-Arm-PEG10000-Norbornene consists of four PEG chains, each modified at the end with norbornene molecules. 4-Arm-PEG10000-Norbornene can be used for bioconjugation and drug delivery.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-W013021
-
-
-
- HY-128478
-
|
|
Microorganisms
Ketones, Aldehydes, Acids
Source Classification
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Fungal
|
|
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .
|
-
-
- HY-W013021R
-
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-151727
-
|
|
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Tetrazine
|
|
Norbornene-NHS is a norbornene-functionalized antibody-drug conjugate linker (ADC Linker) bearing an NHS ester, which is applicable for highly efficient and specific antibody conjugation reactions in ADC research and development. Norbornene-NHS also acts as an azide-group-containing click chemistry reagent, serving as a dienophile for copper-free click reaction conjugation .
|
-
- HY-151742
-
|
|
|
TCO
|
|
Norbornene-methyl-NHS is a norbornene-based antibody-drug conjugate linker (ADC Linker) bearing methyl and NHS ester functional groups, which can be used for specific antibody conjugation. Norbornene-methyl-NHS is also a click chemistry reagent containing a TCO group, acting as a dienophile for conjugation via the Diels-Alder reaction, namely the copper-free click reaction with tetrazine .
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- HY-151682
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Labeling and Fluorescence Imaging
TCO
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H-L-Lys(Norbornene-methoxycarbonyl)-OH is a Norbornene (HY-W013021)-derivatized lysine that can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
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- HY-151682A
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TCO
Labeling and Fluorescence Imaging
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H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride is a Norbornene (HY-W013021)-derivatized lysine that can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH hydrochloride can be used for the mild and selective modification of proteins in a copper-free click reaction .
|
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- HY-186171
-
|
|
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Alkynes
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Mal-(1R,2S,3R,4S)-himic acid-alkyne is a trifunctional click chemistry scaffold containing complementary functionalities for copper catalyzed azide-alkyne (CuAAC), thiol-Michael addition, and inverse electron demand Diels-Alder (iEDDA) click reactions .
|
-
- HY-W422109
-
|
|
|
Tetrazine
|
|
4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid is an asymmetric tetrazine derivative and a bioorthogonal reaction partner. 4-(6-Methyl-1,2,4,5-tetrazin-3-yl) benzoic acid can be conjugated with Bevacizumab (HY-P9906) via EDC/NHS activation while retaining the VEGF-binding affinity of the antibody, thus constructing a targeting agent for pretargeted immuno-PET/NIRF imaging .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W440896
-
|
|
|
Pegylated Lipids
|
|
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
|
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