2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. ZIM

ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research.

For research use only. We do not sell to patients.

ZIM Chemical Structure

ZIM Chemical Structure

CAS No. : 301298-87-3

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5 mg USD 70 In-stock
10 mg USD 110 In-stock
25 mg USD 220 In-stock
50 mg USD 360 In-stock
100 mg USD 580 In-stock
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Based on 1 publication(s) in Google Scholar

ZIM Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research[1].

In Vivo

ZIM (i.p., 12, 24 and 48 mg/kg) can effectively reduce the frequency of chromosome micronucleus at all doses at 24 and 72 h in adult male Swiss mice, and has certain chemoprophylaxis effect, and the percentage of damage reduction ranges from 38.36 to 83.26%[1].
ZIM (i.p., 12, 24 and 48 mg/kg) reduces the frequency of cisplatin-CIS and doxorubicin-DOX-induced liver and kidney cell death. At 12, 24 and 48 mg/kg dosages, the percentage of liver damage reduction in CIS group are 79.27, 75.20 and 52.84%, and that in DOX group are 62.06, 59.44 and 77.80%, respectively. The reduction percentages of kidney injury in CIS group are 45.29, 36.09 and 41.61%, and those in DOX group are 28.00, 21.41 and 30.82%, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

349.38

Formula

C20H19N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(C(N(N1C)C2=CC=CC=C2)=O)N3C(C4C5C=CC(C4C3=O)C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8622 mL 14.3111 mL 28.6221 mL
5 mM 0.5724 mL 2.8622 mL 5.7244 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8622 mL 14.3111 mL 28.6221 mL 71.5553 mL
5 mM 0.5724 mL 2.8622 mL 5.7244 mL 14.3111 mL
10 mM 0.2862 mL 1.4311 mL 2.8622 mL 7.1555 mL
15 mM 0.1908 mL 0.9541 mL 1.9081 mL 4.7704 mL
20 mM 0.1431 mL 0.7156 mL 1.4311 mL 3.5778 mL
25 mM 0.1145 mL 0.5724 mL 1.1449 mL 2.8622 mL
30 mM 0.0954 mL 0.4770 mL 0.9541 mL 2.3852 mL
40 mM 0.0716 mL 0.3578 mL 0.7156 mL 1.7889 mL
50 mM 0.0572 mL 0.2862 mL 0.5724 mL 1.4311 mL
60 mM 0.0477 mL 0.2385 mL 0.4770 mL 1.1926 mL
80 mM 0.0358 mL 0.1789 mL 0.3578 mL 0.8944 mL
100 mM 0.0286 mL 0.1431 mL 0.2862 mL 0.7156 mL
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ZIM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZIM301298-87-3DNA/RNA SynthesisDNA damagechromosomalcell deathphagocytosischemotherapeuticcancerInhibitorinhibitorinhibit

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