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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Notch3
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Notch3" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: Notch inhibitor 1
BMS-986115 (Notch inhibitor 1) is a potent Notch inhibitor, with IC50s of 7.8 and 8.5 nM for Notch 1 and Notch 3, respectively. Used in the research of cancer .
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NSC 405020 is a specific MMP14 inhibitor. NSC 405020 can directly interact with the hemopexin domain of MMP14. NSC 405020 reduces the expression of full length and active cleaved Notch3 (NICD3). NSC 405020 can be used to research vestibular schwannoma, hemostasis and thrombosis [3].
3
3 Cited Publications
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BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC50s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .
1
Cat. No.: HY-P99320
CAS No.: 1359940-55-8
Synonyms: OMP 59R5; Anti-Human Notch2 Recombinant Antibody
Cat. No.: HY-RS09451
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NOTCH3 Human Pre-designed siRNA Set A contains three designed siRNAs for NOTCH3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS17213
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Notch3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Notch3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23665
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Notch3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Notch3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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S2116, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2116 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2116 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2116 significantly retardes the growth of T-ALL cells in xenotransplanted mice .
Cat. No.: HY-15211
CAS No.: 623165-93-5
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MRK 003 is an orally active γ-secretase inhibitor. MRK 003 targets the Notch signaling pathway by blocking the proteolytic cleavage of Notch receptors. MRK 003 inhibits tumor cell proliferation, induces apoptosis, downregulates anti-apoptotic proteins, upregulates phosphorylated Akt, suppresses angiogenesis, and overcomes microenvironment-mediated proliferative protection. MRK 003 can be used in research related to lung cancer, multiple myeloma, non-Hodgkin's lymphoma, pancreatic ductal adenocarcinoma, glioblastoma, and breast cancer [3] .
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S2157, a N-alkylated tranylcypromine (TCP) derivative, is a potent lysine-specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super-enhancer regions. S2157 induces apoptosis in TCP-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood-brain barrier and can almost completely eradicate CNS leukemia in mice transplanted with T-ALL cells .
Cat. No.: HY-P990477
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Cat. No.: HY-P992438
Synonyms: Anti-Notch3 mAb hu28
Cat. No.: HY-P700804
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CADASIL; Notch homolog 3; Notch-3; Notch3
Cat. No.: HY-P700803
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CADASIL; Notch homolog 3; Notch-3; Notch3
Cat. No.: HY-P86989
Synonyms: FLJ16302 antibody; hNotch 4 antibody; hNotch4 antibody; INT3 antibody; Neurogenic locus Notch homolog protein 4 antibody; NOTC4_HUMAN antibody; Notch 4 antibody; Notch 4 intracellular domain antibody; Notch homolog 4 antibody; Notch3 antibody; FLJ16302 antibody; hNotch 4 antibody; hNotch4 antibody; INT3 antibody; Neurogenic locus Notch homolog protein 4 antibody; NOTC4_HUMAN antibody; Notch 4 antibody; Notch 4 intracellular domain antibody; Notch homolog 4 antibody; Notch3 antibody; Notch4 antibody; Notch4 protein antibody;
Cat. No.: HY-P74683
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Neurogenic locus Notch homolog protein 4; hNotch4; INT3
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
