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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
PCC
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "PCC" in MCE Product Catalog:
11
Category:
Rosaceae Extract Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Disease Research Fields Biflavones Cancer
Target:
3
3 Cited Publications
PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability .
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PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala .
Cat. No.: HY-W353469
CAS No.: 22160-26-5
Synonyms: Glucosylglycerol
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Cat. No.: HY-N2342R
CAS No.: 37064-30-5
Synonyms: PCC1 (Standard)
Category:
Flavonoids Rosaceae Extract Phenols Polyphenols Crataegus pinnatifida Bge. Plants Biflavones
Target:
Cat. No.: HY-P11337
CAS No.: 403479-63-0
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Cat. No.: HY-161771
CAS No.: 2347368-51-6
JNJ-7184 is a non-nucleoside inhibitor of the RSV-Large (L) polymerase, with the pEC50 and pCC50 of 7.86 and 4.29 in Hela cells, respectively. JNJ-7184 prevents RSV replication and transcription by inhibiting initiation or early elongation .
Cat. No.: HY-159113
CAS No.: 3123359-15-6
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PCC0105003 is a potent MARK inhibitor. PCC0105003 can be used in the study of neuropathic pain .
Cat. No.: HY-169232
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Cat. No.: HY-P1089
CAS No.: 86579-06-8
Synonyms: PCC 88-104
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Cat. No.: HY-RS03215
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CRYGD Human Pre-designed siRNA Set A contains three designed siRNAs for CRYGD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-169235
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Cat. No.: HY-169236
CAS No.: 947504-71-4
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COOH-C-PEG2-NHCO-C2-COOH is a PROTAC linker that is used to synthesize PCC16 chloride (HY-169232) .
Cat. No.: HY-169237
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Pomalidomide-C2-CONH-PEG2-C-COOH is a conjugate of E3 ligase ligand and linker and can be used in the synthesis of PCC16 chloride (HY-169232) .
Cat. No.: HY-179684
CAS No.: 2921670-99-5
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PCC0105005 is a dual-target CGRP Receptor antagonist (IC50 = 1.01 nM) and a partial agonist of 5-HT1F Receptor (EC50 = 77.91 nM). PCC0105005 shows significant efficacy in the rat model of migraine. PCC0105005 significantly reduces the expression of CGRP and c-Fos proteins, and inhibits the phosphorylation levels of ERK and CREB. PCC0105005 can be used for research on migraine .
Cat. No.: HY-155726
CAS No.: 444792-16-9
Cy-FBP/SBPase-IN-1 (compound S5) is a Cy-FBP/SBPase inhibitor, which is an important regulatory enzyme in cyanobacterial photosynthesis. Thus Cy-FBP/SBPase-IN-1 inhibits Calvin cycle and photosystem, and decreases photosynthetic efficiency in cyanobacterial photosynthesis. Cy-FBP/SBPase-IN-1 potently inhibits the growth of cyanobacteria, as well as Synechocystis sp.PCC6803. Cy-FBP/SBPase-IN-1 shows safety profile in human-derived cells and zebrafish models .
Cat. No.: HY-184378
CAS No.: 2922221-22-3
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MDB5 is a Hedgehog pathway and Smoothened inhibitor that binds to the 7-TM domain of Smo . MDB5 reduces hepatic stellate cell activation, extracellular matrix-related gene expression, collagen deposition, hydroxyproline content and epithelial-mesenchymal transition, and prevents sinusoidal endothelial cell capillarization . MDB5 induces G1 and S phase cell cycle arrest, triggers apoptosis by upregulating Bax and downregulating Bcl-2, and also decreases oxygen consumption rate, glucose uptake, transglutaminase activity and fibronectin matrix assembly . MDB5 reduces the levels of liver injury markers, hepatic triglyceride deposition and hepatic steatosis, restores the tissue structure of the kidney and spleen, and inhibits pancreatic tumor growth without causing body weight loss . MDB5 can be loaded into PEG-PCC-g-DC micelles, achieving high drug loading, sustained release, improved water solubility, enhanced cellular uptake and optimized hepatic distribution, with good tolerance in mice . MDB5 is applicable to research related to alcohol-associated liver disease, liver fibrosis and pancreatic cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
