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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
Pyrazine
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "Pyrazine" in MCE Product Catalog:
21
21 Cited Publications
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SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
Cat. No.: HY-W013040
CAS No.: 290-37-9
Synonyms: 1,4-Diazine
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Cardiovascular Disease Infection Inflammation/Immunology Cancer
Pyrazine (1,4-Diazine) is an aromatic nitrogen-containing heterocyclic compound with two nitrogen atoms, and is well known for its electron-deficient property. Pyrazine serves as a key pharmacophore in a variety of drugs, and also acts as the core skeleton of derivatives with anticancer, antimycobacterial, antithrombotic and anti-inflammatory activities .
Cat. No.: HY-Y0109
CAS No.: 14508-49-7
Synonyms: Pyrazin-2-yl chloride
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Chloropyrazine (Pyrazin-2-yl chloride) is a pyrazine compound that can be used for the synthesis of active compounds. Chloropyrazine can also serve as an electrolyte additive for research on lithium-sulfur batteries .
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Gcase activator 2 (compound 14), a pyrrolo[2,3-b]pyrazine, is alos a β-Glucocerebrosidase (GCase) activator (EC50=3.8 μM). Gcase activator 2 induces GCase dimerizatio (both K-type and V-type). And Gcase activator 2 has low metabolic clearance in human and mouse .
Cat. No.: HY-W031471A
CAS No.: 51285-05-3
Pyrazine-2-amidoxime is a structural analogue of pyrazine-2-carboxamide with antimicrobial activity. Pyrazine-2-amidoxime shows killing and inhibiting properties against Candida albicans, fungal pathogen and Gram-positive bacteria .
Cat. No.: HY-Y0131
CAS No.: 19847-12-2
Cat. No.: HY-76120
CAS No.: 762240-92-6
Synonyms: Intermediate Ⅰ of sitagliptin phosphate
Cat. No.: HY-112547
CAS No.: 1034297-58-9
Synonyms: CRT0066051
CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis .
JAK-IN-25 (compound 19) is a potent JAK inhibitor with IC50s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2, JAK1, JAK2, JAK3, respectively. JAK-IN-25 inhibits human whole blood IL-12 (HEB IL-12) with an IC50 of 28 nM. JAK-IN-25 has the potential for cancer research .
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Pyrazine-2-carbaldehyde is a heterocyclic aromatic carbaldehyde and can be used as a drug intermediate.
Cat. No.: HY-W013040S
CAS No.: 1758-62-9
Synonyms: 1,4-Diazine-d4
Cat. No.: HY-W044751
CAS No.: 179605-64-2
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(R)-Octahydro-pyrido[1,2-A]pyrazine is a drug intermediate for synthesis of various active compounds.
Cat. No.: HY-W129661
CAS No.: 4604-72-2
Pyrazine-2-carbothioamide is an effective antituberculosis agent with inhibitory activity against mycobacterium in vitro .
Cat. No.: HY-W025580
CAS No.: 43193-60-8
Synonyms: Pyrazinetetracarboxylic acid
Pyrazine-2,3,5,6-tetracarboxylic acid (Pyrazinetetracarboxylic acid) is a metal-organic framework (MOF).
Cat. No.: HY-W017105
CAS No.: 89-01-0
Synonyms: 2,3-DicarboxyPyrazine
Cat. No.: HY-W716669
CAS No.: 952-54-5
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Morinamide is an antibacterial agent, antitubercular agent and Pyrazine (HY-W013040) derivative. Morinamide can be used in the research of tuberculosis .
Cat. No.: HY-178448
Target:
EGFR JAK Ferroptosis Apoptosis Reactive Oxygen Species (ROS) Cannabinoid Receptor Glutathione Peroxidase Caspase
Research Areas:
EGFR-IN-178 is an orally active EGFR mutant inhibitor, exhibits highly selective inhibitory activity against mutants of the EGFR enzyme, including Del19 (IC50 = 3.4 nM), L858R/T790 M (IC50 = 2.9 nM), and Del19/T790 M (IC50 = 2.5 nM). EGFR-IN-178 has good activity against JAK2 (IC50 = 55.6 nM) and JAK3 (IC50 = 46.1 nM) kinases. EGFR-IN-178 can increase cellular lipid oxide MDA, meanwhile decrease GSH content, causing ferroptosis in cancer cells. EGFR-IN-178 promotes apoptosis by increasing cleaved caspase-3 expression. EGFR-IN-178 can inhibit the phosphorylation of EGFR protein and decrease the active form p-JAK2 for JAK2, induce an increase in intracellular ROS. EGFR-IN-178 can be used for the study of non-small cell lung cancer (NSCLC) .
Cat. No.: HY-135078
CAS No.: 17460-13-8
Synonyms: NSC 270912
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2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
Cat. No.: HY-W017105R
CAS No.: 89-01-0
Synonyms: 2,3-DicarboxyPyrazine (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
