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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
RPE cell
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "RPE cell" in MCE Product Catalog:
4
Target:
Cat. No.: HY-D1742
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
WS3 is an allosteric inhibitor of 14-3-3 (14-3-3ζ: Kd = 2.29 μM). WS3 activates GSK3β by disrupting the binding of 14-3-3-pGSK3β, promotes the ubiquitination and degradation of NRF2, and inhibits the NRF2-ARE signaling pathway (IC50 = 135 nM). It exerts antioxidant inhibition and chemotherapeutic/ferroptosis sensitizing effects in tumors with hyperactivated NRF2. WS3 binds to EBP1/IKKε and promotes the proliferation of β cells and retinal pigment epithelial (RPE) cells, which can be applied to islet regeneration and RPE expansion transplantation . WS3 is applicable to research related to age-related macular degeneration, retinal degeneration and non-small cell lung cancer .
Cat. No.: HY-N11499
CAS No.: 132679-85-7
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Cat. No.: HY-P10926
CAS No.: 2950154-05-7
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Cat. No.: HY-P4859
CAS No.: 29227-88-1
Synonyms: Pyr-Gly-OH; H-Pyr-Gly-OH
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Research Areas:
Cat. No.: HY-D2396
Synonyms: Sulfo SMCC R-PE
Cat. No.: HY-162904
CAS No.: 2198977-68-1
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Research Areas:
BPU17 binds to PHB1 and causes mild defects in mitochondrial function by defects in the PHB1-PHB2 interaction. This impairment inhibits the SRF/CArG-box-dependent transcription, resulting in the suppression of epithelial-mesenchymal transition (EMT) of retinal pigment epithelial cells (RPEs). BPU17 exhibits antifibrotic activity in vivo. BPU17 is promising for research of anti-neovascular age-related macular degeneration (nAMD) agent .
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Target:
Cat. No.: HY-P5169
CAS No.: 608513-82-2
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Cat. No.: HY-P5169A
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Research Areas:
Cat. No.: HY-D0988A
CAS No.: 11016-17-4
Synonyms: R-PE (concentrated solution)
Cat. No.: HY-D0988B
CAS No.: 11016-17-4
Synonyms: R-PE ammonium sulfate precipitate
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
