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SPM

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By Targets:	Apoptosis (1) Autophagy (1) Bacterial (1) COX (1) Drug Derivative (1) Endogenous Metabolite (1) Ferroptosis (1) GPR84 (1) Influenza Virus (1) Interleukin Related (1) JNK (2) Liposome (2) Lipoxygenase (1) PPAR (1) Small Interfering RNA (siRNA) (1) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Cationic Lipids (2) siRNAs (1)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113512

17-HDHA	Influenza Virus	Inflammation/Immunology
17-HDHA is a DHA-derived specialized proresolving mediator (SPM). 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27 ⁺ CD38 ⁺ antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells .

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	STAT COX Lipoxygenase JNK Endogenous Metabolite	Neurological Disease Inflammation/Immunology
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

HY-112402

SP 600125, negative control JNK Inhibitor II, negative control	Autophagy Apoptosis JNK Ferroptosis	Cancer
SP 600125, negative control (SPM1) is an alkyl derivative of pyrazoloanthrone, which can be used as a negative control for SP600125 (HY-12041) .

HY-163044

C12-SPM	Liposome	Infection
C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases .

HY-120255

17(R)-HDHA 17(R)-HDoHE	Drug Derivative	Inflammation/Immunology
17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27(+)CD38(+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells .

HY-120255A

17(S)-HDHA	PPAR	Metabolic Disease
17(S)-HDHA is a pro-resolving mediator (SPM). 17(S)-HDHA slightly activats PPARγ, PPARα and PPARδ .

HY-160569

C14-SPM	Liposome	Inflammation/Immunology
C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA .

HY-130322

Maresin Conjugates in Tissue Regeneration 2 MCTR2	Others	Inflammation/Immunology
Maresin Conjugates in Tissue Regeneration 2 is a specialized pro-resolving mediator (SPM). Maresin Conjugates in Tissue Regeneration 2 can be used in the study of anti-inflammatory .

HY-125445

PCTR1	Bacterial	Inflammation/Immunology
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs) .

HY-168782

Resolvin D2 n-3 DPA	TNF Receptor Interleukin Related	Inflammation/Immunology
Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide .

HY-RS16778

Npc1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Npc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Npc1 Mouse Pre-designed siRNA Set A Npc1 Mouse Pre-designed siRNA Set A

HY-183624

Trimer44NMe	Others	Cancer
Trimer44NMe is a polyamine transport inhibitor (PTI). Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm). Trimer44NMe can be used for research of Pancreatic ductal adenocarcinoma (PDAC) .

HY-167754

Resolvin D5 n-3 DPA	GPR84	Inflammation/Immunology
Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC₅₀s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113509B

15(R)-Lipoxin A4 15-epi-LXA4	Structural Classification Natural Products Source Classification	STAT COX Lipoxygenase JNK Endogenous Metabolite
15 (R)-Lipoxin A4 (15-epi-LXA4) is a specialized pro-resolving mediator and an acetylated derivative of COX2. 15 (R)-Lipoxin A4 is present in neurons. 15 (R)-Lipoxin A4 induces the SPM synthases ALOX12 and ALOX15, as well as the pro-resolving receptor ALX. 15 (R)-Lipoxin A4 inhibits protein kinases, including JNK1/2/3, Lyn, STAT-3 and STAT-6. 15 (R)-Lipoxin A4 enhances the release of pro-resolving mediators. 15 (R)-Lipoxin A4 alleviates the pro-inflammatory phenotype of tendon-derived stromal cells. 15 (R)-Lipoxin A4 promotes the resolution of neuroinflammation. 15 (R)-Lipoxin A4 is applicable to research related to achilles tendinitis, achilles tendon rupture and Alzheimer’s disease .

Cat. No.	Product Name		Classification

HY-163044

C12-SPM		Cationic Lipids
C12-SPM is a lipid that mediates siRNA delivery. C12-SPM has no significant cytotoxicity and can be used for research on hepatoviral diseases .

HY-160569

C14-SPM		Cationic Lipids
C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA .

HY-RS16778

Npc1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Npc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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SPM

Inhibitors & Agonists

NaturalProducts

Oligonucleotides

Natural
Products