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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
SPM
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "SPM" in MCE Product Catalog:
7
7 Cited Publications
Synonyms: SAR442168; PRN2246
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Tolebrutinib (SAR442168) is an orally active, selective, and blood-brain barrier-penetrant BTK inhibitor with neuroactive properties. Tolebrutinib is being investigated for use in multiple sclerosis (MS), particularly secondary progressive multiple sclerosis (SPMS). .
Cat. No.: HY-113509B
CAS No.: 171030-11-8
Synonyms: 15-epi-LXA4
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Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology
17-HDHA is a DHA-derived specialized pro-resolving mediator (SPM). 17-HDHA inhibits NF-κB activation by activating PPARγ and upregulating IκBα, targets FPR2 and Bcl-6, and also acts as a precursor of RvD1 and PD1. 17-HDHA inhibits pulmonary artery smooth muscle cell proliferation, regulates the expression of adiponectin, GLUT-4 and inflammatory cytokines, suppresses IgE production by B cells and promotes antibody secretion. 17-HDHA reduces adipose tissue inflammation, improves insulin sensitivity and glucose tolerance, alleviates pathological processes associated with pulmonary hypertension, and enhances antibody responses and virus neutralizing activity against influenza HA. 17-HDHA can be used in research related to obesity-associated inflammation, insulin resistance, glucose intolerance, pulmonary hypertension and influenza virus infection .
Synonyms: JNK Inhibitor II, negative control
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SP 600125, negative control (SPM1) is an alkyl derivative of pyrazoloanthrone, which can be used as a negative control for SP600125 (HY-12041) .
Cat. No.: HY-120255
CAS No.: 155976-53-7
Synonyms: 17(R)-HDoHE
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17(R)-HDHA (17(R)-HDoHE) is a pro-resolving mediator (SPM). 17(R)-HDHA enhances the differentiation of B cells toward the CD27(+)CD38(+) antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells. 17(R)-HDHA does not affect cell proliferation and is non-toxic to cells .
Cat. No.: HY-120255A
CAS No.: 92693-03-3
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17(S)-HDHA is a pro-resolving mediator (SPM). 17(S)-HDHA slightly activats PPARγ, PPARα and PPARδ .
Cat. No.: HY-160569
CAS No.: 2241864-59-3
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C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA .
Cat. No.: HY-130322
CAS No.: 1784701-62-7
Synonyms: MCTR2
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Maresin Conjugates in Tissue Regeneration 2 is a specialized pro-resolving mediator (SPM). Maresin Conjugates in Tissue Regeneration 2 can be used in the study of anti-inflammatory .
Cat. No.: HY-125445
CAS No.: 1810710-59-8
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PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs) .
Cat. No.: HY-168782
CAS No.: 2093111-29-4
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Resolvin D2 n-3 DPA is a specialized proresolving mediator (SPM). Resolvin D2 n-3 DPA (1 nM) can reduce the chemotaxis and adhesion of human neutrophils induced by TNF-α. Resolvin D2 n-3 DPA (100 ng/mouse; intravenous injection) can reduce neutrophil infiltration in the peritoneum and the levels of IL-6 and the chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of inflammation induced by zinc oxide .
Cat. No.: HY-RS16778
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Npc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-183624
CAS No.: 1258530-99-2
Trimer44NMe is a polyamine transport inhibitor (PTI). Trimer44NMe inhibits the polyamine transport of putrescine (Put), spermidine (Spd), and spermine (Spm). Trimer44NMe can be used for research of Pancreatic ductal adenocarcinoma (PDAC) .
Cat. No.: HY-109192R
CAS No.: 1971920-73-6
Synonyms: SAR442168 (Standard); PRN2246 (Standard)
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Tolebrutinib (SAR442168) (Standard) is the analytical standard of Tolebrutinib (HY-109192). This product is intended for research and analytical applications. Tolebrutinib (SAR442168) is an orally active, selective, and blood-brain barrier-penetrant BTK inhibitor with neuroactive properties. Tolebrutinib is being investigated for use in multiple sclerosis (MS), particularly secondary progressive multiple sclerosis (SPMS) .
Cat. No.: HY-167754
CAS No.: 1609382-32-2
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Resolvin D5 n-3 DPA is a Docosapentaenoic acid (DPA) derived specialized proresolving lipid mediator (SPM). Resolvin D5 n-3 DPA is a GPR101, GPR12, and GPR84 agonist with EC50s of 4.6 pM, 14 pM, and 1.5 pM, respectively. Resolvin D5 n-3 DPA possesses potent pro-resolution and anti-inflammatory actions. Resolvin D5 n-3 DPA reduces cell adhesion onto TNF-α-activated human endothelial monolayers. Resolvin D5 n-3 DPA displays potent leukocyte-directed activities, upregulating the ability of neutrophils and macrophages to phagocytose bacteria. Resolvin D5 n-3 DPA can be used for the study of intestinal inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
