STAT5a

Isoforms Recommended:	STAT5

By Targets:	STAT (7) Apoptosis (2) Endogenous Metabolite (1) JAK (1) Ligands for Target Protein for PROTAC (1) PROTACs (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Inflammation/Immunology (1)
Click Chemistry:	PROTAC Synthesis (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: STAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148813

AK-2292 2 Publications Verification	PROTACs STAT	Cancer
AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC₅₀ of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models . AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-169182

AK-068	Ligands for Target Protein for PROTAC STAT	Cancer
AK-068 is a high-affinity and selective *STAT6* ligand, with a K_i of 6 nM. AK-068 demonstrates at least >150- and >85-fold binding selectivity over *STAT5A* (K_i >1 μM) and *STAT5B* (K_i >500 μM) proteins, respectively. AK-068 is a ligand for target protein for PROTAC, can be used for synthesis of PROTACs .

HY-136546

Stafia-1 1 Publications Verification	STAT	Cancer
Stafia-1 is a potent *STAT5a* inhibitor (K_i=10.9 μM, IC₅₀=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members .

HY-112648

Stafib-2	STAT	Others
Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC₅₀ of 82 nM and 1.7 μM for *STAT5b* and *STAT5a*, respectively. Stafib-2 exhibits poor cell permeability .

HY-19527

IST5-002 1 Publications Verification N6-Benzyladenosine-5'-phosphate	STAT Apoptosis	Cancer
IST5-002, a potent *Stat5a/b* inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC₅₀s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML) .

HY-RS13892

STAT5A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT5A Human Pre-designed siRNA Set A contains three designed siRNAs for STAT5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT5A Human Pre-designed siRNA Set A STAT5A Human Pre-designed siRNA Set A

HY-RS19077

Stat5a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat5a Mouse Pre-designed siRNA Set A Stat5a Mouse Pre-designed siRNA Set A

HY-RS25568

Stat5a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stat5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stat5a Rat Pre-designed siRNA Set A Stat5a Rat Pre-designed siRNA Set A

HY-170837

STAT5-IN-3	STAT	Cancer
STAT5-IN-3 (Compound 14a) is a *STAT5* inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of *STAT5A/5B* at the Y694/699 sites and significantly reduces the expression of *STAT5B* protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance .

HY-182430

NVP-BVB808	JAK STAT Apoptosis	Cancer
NVP-BVB808 is a selective and ATP-competitive JAK2 inhibitor with an IC₅₀ of 0.35 nM. NVP-BVB808 binds to JAK2’s ATP-binding site, stabilizes JAK2’s active conformation, increases JAK2 activation loop phosphorylation, and blocks downstream kinase function. NVP-BVB808 exhibits antiproliferative and pro-apoptosis effects, suppresses constitutive *STAT5a* phosphorylation. NVP-BVB808 can be used for the research of cancer, such as leukemia .

HY-115464

NC1153	Endogenous Metabolite	Inflammation/Immunology
NC1153 is a Mannich base with the activity to block IL-2-induced JAK3 activation and its downstream substrate STAT5a/b. NC1153 effectively prolongs the survival of kidney transplants in MHC/non-MHC mismatched rats. NC1153 promotes long-term graft survival and includes multiple toxicity protection for recipients. NC1153 combined with cyclosporine A (CsA) can synergistically prolong graft survival without producing nephrotoxicity, myelotoxicity or lipotoxicity .

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	704 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 704 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

704 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 704 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702987

	STAT5A Protein, Human (sf9, His) STAT5	Human	Sf9 insect cells
	STAT5A Protein, Human (sf9, His) is the recombinant human-derived STAT5, expressed by Sf9 insect cells , with His labeled tag. ,

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Source
Tag
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Host:	Mouse (2) Rabbit (7)
Reactivity:	Human (9) Rat (5) Mouse (7)
Application:	IHC-P (8) ICC/IF (8) IP (5) WB (9) FC (3) ELISA (5)
Isotype:	IgG (7) IgG1 (2)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (8) Recombinant (4)
Modification:	Phosphorylated (2) Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80345

	STAT5a Antibody (YA053)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	STAT5a Antibody (YA053) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5a.

HY-P86240

	STAT5a Antibody (YA5932) STAT5a; STAT5; Signal transducer and activator of transcription 5a	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT5a Antibody (YA5932) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5a.

HY-P80479

	*Phospho-STAT5a* (Tyr694) Antibody (YA145)** STAT5a; STAT5; Signal transducer and activator of transcription 5a	WB, IHC-P, ICC/IF	Human, Rat, Mouse
	Phospho-STAT5a (Tyr694) Antibody (YA145) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT5a (Tyr694).

HY-P81768

	*Phospho-STAT5(Tyr694) Antibody (YA1513)* STAT5a; STAT5; Signal transducer and activator of transcription 5a	WB, IHC-P	Human, Mouse
	Phospho-STAT5(Tyr694) Antibody (YA1513) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT5(Tyr694).

HY-P84315

	STAT5a Antibody (YA4012) MGF; STAT5	WB, IHC-P, ICC/IF, FC, ELISA	Human
	STAT5a Antibody (YA4012) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to STAT5a.

HY-P86331

	STAT5a+b Antibody (YA6023) STAT5a; STAT5; Signal transducer and activator of transcription 5a; STAT5B; Signal transducer and activator of transcription 5B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	STAT5a+b Antibody (YA6023) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5a+b.

HY-P84315A

	STAT5a Antibody (YA4012)(PBS only) MGF; STAT5	WB, IHC-P, ICC/IF, FC, ELISA	Human
	STAT5a Antibody (YA4012) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to STAT5a.

HY-P86203

	*Phospho-STAT5a+b(Tyr694) Antibody (YA5895)* STAT5a; STAT5; Signal transducer and activator of transcription 5a; STAT5B; Signal transducer and activator of transcription 5B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-STAT5a+b(Tyr694) Antibody (YA5895) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-STAT5a+b(Tyr694).

HY-P80904

	STAT5a+b Antibody (YA054) MGF; STAT5	WB, ICC/IF, IP	Human, Mouse, Rat
	STAT5a+b Antibody (YA054) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STAT5a+b.

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Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
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Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
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Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-148813

AK-2292 2 Publications Verification		PROTAC Synthesis
AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC₅₀ of 0.10 μM. AK-2292 induces degradation of STAT5A/B proteins in vitro and in vivo. AK-2292 can induce tumor regression in acute myeloid leukemia and chronic myeloid leukemia xenograft mouse models . AK-2292 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS13892

STAT5A Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
STAT5A Human Pre-designed siRNA Set A contains three designed siRNAs for STAT5A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19077

Stat5a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Stat5a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat5a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25568

Stat5a Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Stat5a Rat Pre-designed siRNA Set A contains three designed siRNAs for Stat5a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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