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Isoforms Recommended: TGFβR2
Results for "

TGFβ-R2

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

5

Recombinant Proteins

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-117887
    Fidrisertib

    BLU-782; IPN-60130; ALK2-IN-1

    		 TGF-β Receptor Cancer
    Fidrisertib (BLU-782) is the orally active inhibitor for activin receptor-like kinase 2 (ALK2) that inhibits ALK2 R206H, ALK2, ALK1, ALK6, ALK3, ALK4, TGFβR2 and ALK5 with IC50s of 0.2, 0.6, 3, 24, 45, 65, 67 and 155 nM, respectively [2].
    Fidrisertib
  • HY-W107024
    BMS-986260

    		TGF-β Receptor Inflammation/Immunology Cancer
    BMS-986260, an immuno-oncology agent, is a potent, selective, and orally active TGFβR1 inhibitor (IC50=1.6 nM). BMS-986260 displays exquisite selectivity for TGFβR1 over its isozyme TGFβR2, as well as in a panel of more than 200 kinases examined. BMS-986260 inhibits TGFβ mediated nuclear translocation of pSMAD2/3 in MINK and NHLF cells lines with an IC50 of 350 nM and 190 nM, respectively .
    BMS-986260
  • HY-E70867
    TGFβR2 Recombinant Human Active Protein Kinase

    		TGF-β Receptor Metabolic Disease
    TGF-β is a pleiotropic multifunctional cytokine that regulates many cellular processes, such as cell growth, differentiation, apoptosis and cellular homeostasis. Before exerting the biological effects within cells, TGF-β first requires extracellular activation, namely binds to its type II receptor (TGFβR2) and promotes the phosphorylation. TGFβR1 plays an important role in TGF-β signaling transduction and serves as a tumor suppressor. TGFβR2 Recombinant Human Active Protein Kinase is a recombinant TGFβR2 protein that can be used to study TGFβR2-related functions .
    TGFβR2 Recombinant Human Active Protein Kinase
  • HY-183950
    ALK5-IN-87

    		Anaplastic lymphoma kinase (ALK) Inflammation/Immunology
    ALK5-IN-87 is a potent lung-restricted ALK5 inhibitor with a pKi of 10.13. ALK5-IN-87 exerts antifibrotic activity in a mouse model of lung fibrosis. ALK5-IN-87 can be used for the research of idiopathic pulmonary fibrosis .
    ALK5-IN-87

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