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TRAIL-R2/DR5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) TNF Receptor (1)
By Research Areas:	Cancer (2)

2

Inhibitors & Agonists

2

Inhibitory Antibodies

12

Recombinant Proteins

3

Antibodies

Targets Recommended: CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Conatumumab AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody	TNF Receptor	Cancer
Conatumumab (AMG 655) is a human monoclonal agonist antibody against human *death receptor 5 (DR5, TRAILR2)* (K_d: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. ^[2] .

Lexatumumab HGS-ETR 2; ETR2-ST01	Apoptosis	Cancer
Lexatumumab (HGS-ETR 2) is a human agonistic **TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis** in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .

Cat. No.	Product Name	Target	Research Area	Image

Conatumumab AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody	TNF Receptor	Cancer
Conatumumab (AMG 655) is a human monoclonal agonist antibody against human *death receptor 5 (DR5, TRAILR2)* (K_d: 1 nM for the long form of DR5, 0.8 nM for the short form of DR5). Conatumumab induces apoptosis via caspase activation. Conatumumab can be used in the research of cancers. ^[2] .

Lexatumumab HGS-ETR 2; ETR2-ST01	Apoptosis	Cancer
Lexatumumab (HGS-ETR 2) is a human agonistic **TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis** in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .

Species:	Human (7) Mouse (4) Cynomolgus (1)
Tag:	His (8) Tag Free (2) Avi (3) Fc (3)
Source:	HEK293 (11) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

	TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) TNFRSF10B; TRAILR2; TRAIL-R2; CD262; DR5; KILLER; TRICK2; ZTNFR9; TRICKB	Cynomolgus	HEK293
	TRAIL R2/TNFRSF10B Protein serves as a receptor for the cytotoxic ligand TNFSF10/TRAIL. Upon ligand binding, the adapter molecule FADD recruits caspase-8 to the activated receptor, forming the death-inducing signaling complex (DISC). This activation leads to a cascade of caspases, mediating apoptosis. TRAIL R2/TNFRSF10B lacks conserved residue(s) crucial for feature annotation propagation. TRAIL R2/TNFRSF10B Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Human (HEK293, hFc) Tumor necrosis factor receptor superfamily member 10B; CD262; TRAIL-R2; DR5; KILLER; TRAILR2; ZTNFR9	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (HEK293, hFc) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag.

	TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His) Tumor necrosis factor receptor superfamily member 10B; CD262; TRAIL-R2; DR5; KILLER; TRAILR2; ZTNFR9	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Human Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9	Human	E. coli
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by E. coli , with tag free.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Human (HEK293) rHuTRAILR-2/TNFRSF10B; CD262; DR5; KILLER	Human	HEK293
	TRAIL R2/TNFRSF10B Protein, Human (HEK293) is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis.

	TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His-Avi) CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) Tumor Necrosis Factor Receptor Superfamily Member 10B; Death Receptor 5; TNF-Related Apoptosis-Inducing Ligand Receptor 2; TRAIL Receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9	Human	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and recruits caspase-8 through FADD to initiate cell apoptosis. It forms the death-inducing signaling complex (DISC), activates caspases and mediates apoptosis. TRAIL R2/TNFRSF10B Protein, Human (127a.a, HEK293, His) is the recombinant human-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-6*His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; CD262; Tnfrsf10b; DR5; Killer	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; MK; CD262; Tnfrsf10b; DR5; Killer	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, Avi-His) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

	TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) Tumor necrosis factor receptor superfamily member 10B/Death receptor 5/MK/CD262/Tnfrsf10b/DR5/Killer	Mouse	HEK293
	TRAIL R2/TNFRSF10B protein is the receptor of TNFSF10/TRAIL and activates apoptosis through FADD-mediated recruitment of caspase-8 to form death-inducing signaling complex (DISC).It initiates caspase cascade-mediated apoptosis and promotes NF-kappa-B activation, which is critical for ER stress-induced apoptosis.TRAIL R2/TNFRSF10B Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TRAIL R2/TNFRSF10B protein, expressed by HEK293 , with C-hFc labeled tag.

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Host:	Mouse (3)
Reactivity:	Human (3) Mouse (3)
Application:	ICC/IF (3) WB (3)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (3) Biotin (2)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

	DR5 Antibody (YA5269) Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; Death receptor 5; DR 5; DR5; Fas like protein precursor; KILLER; KILLER/DR5; OTTHUMP00000123492; OTTHUMP00000123493; p53 regulated DNA damage inducible cell death receptor; killer; p53 regulated DNA damage inducible cell death receptor; killer; TNF related apoptosis inducing ligand receptor 2; TNF related apoptosis inducing ligand receptor 2; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TR10B_HUMAN; TRAIL R2; TRAIL receptor 2; TRAIL-R2; TRAILR2; TRANCER; TRICK2; TRICK2A; TRICK2B; TRICKB; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor like protein ZTNFR9; Tumor necrosis factor receptor superfamily member 10b; Tumor necrosis factor receptor superfamily, member 10b; ZTNFR9.	WB, ICC/IF	Human, Mouse
	DR5 Antibody (YA5269) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to DR5.

	DR5 Antibody (YA660) Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; D	WB, ICC/IF	Human, Mouse
	DR5 Antibody (YA660) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DR5.

	DR5 Antibody (YA660)(PBS only) Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L; D	WB, ICC/IF	Human, Mouse
	DR5 Antibody (YA660) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DR5.

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