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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
958 Results for "
Trans-(
" in MedChemExpress (MCE) Product Catalog:
Products (958)
958 Results for "Trans-(" in MCE Product Catalog:
270
270 Publications Verification
Synonyms: ICI 47699; (Z)-Tamoxifen; Trans-Tamoxifen
Target:
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil (HY-Y1888) for use in inducing gene knockout in CreER transgenic mice. Tamoxifen has better solubility in corn oil compared to Tamoxifen Citrate (HY-13757) .
270
270 Publications Verification
Synonyms: ICI 46474; (Z)-Tamoxifen Citrate; Trans-Tamoxifen Citrate
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen Citrate activates autophagy and induces apoptosis. Tamoxifen Citrate can also be used to induce gene knockout in CreER transgenic mice .
174
150
150 Cited Publications
Synonyms: Vitamin A acid; all-Trans-Retinoic acid; ATRA
59
59 Cited Publications
Cat. No.: HY-16950
CAS No.: 68047-06-3
Synonyms: (Z)-4-Hydroxytamoxifen; Trans-4-Hydroxytamoxifen; (Z)-Afimoxifene
Target:
Research Areas:
4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is an orally active, selective estrogen receptor modulator (SERM). 4-Hydroxytamoxifen ((Z)-4-Hydroxytamoxifen) is also the active metabolic form of Tamoxifen (HY-13757A) in vivo and can be used to induce gene knockout in transgenic mice expressing CreER .
50
50 Cited Publications
Research Areas:
ISRIB (trans-isomer) is a potent inhibitor of PERK with an IC50 of 5 nM. ISRIB potently reverses the effects of eIF2α phosphorylation (IC50=5 nM).
47
47 Cited Publications
Cat. No.: HY-P9917
CAS No.: 375823-41-9
Synonyms: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1
Target:
Research Areas:
Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
26
26 Cited Publications
Synonyms: Astringenin; Trans-Piceatannol
Category:
Microorganisms Rheum palmatum L. Stilbenes Polygonaceae Plants Disease Research Fields Cancer
Target:
22
Target:
Research Areas:
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.
15
10
10 Cited Publications
Synonyms: ML-SI3 (cis/Trans mix)
Target:
Research Areas:
ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 μM and 1.7 μM, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 μM and 9.4 μM, respectively .
9
7
7 Cited Publications
Cat. No.: HY-W019711
CAS No.: 14371-10-9
7
7 Cited Publications
Synonyms: (RS)-Ibotenic acid; DL-Ibotenic acid
Category:
Target:
6
6 Cited Publications
Synonyms: Erythrosphingosine; erythro-C18-Sphingosine; Trans-4-Sphingenine
Target:
6
6 Cited Publications
Cat. No.: HY-W089922
CAS No.: 2673-72-5
Synonyms: Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; Trans-4-Sphingenine hydrochloride
Category:
Target:
6
6 Cited Publications
Synonyms: (-)-(E)-Caryophyllene; (−)-β-caryophyllene; (−)-Trans-Caryophyllene
5
Category:
Plants Endogenous metabolite other families Microorganisms Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Cancer
Target:
5
Category:
Caprifoliaceae Lonicera japonica Thunb. Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer
Target:
5
5 Cited Publications
Cat. No.: HY-118861
CAS No.: 15690-57-0
Synonyms: (E)-Clomiphene; Trans-Clomiphene; Enclomifene
Target:
Research Areas:
Enclomiphene ((E)-Clomiphene) is a potent and orally active non-steroidal estrogen receptor antagonist, with antioestrogenic property. Enclomiphene can be used for the research of ovarian dysfunction, testosterone deficiency, male hypogonadism and type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
