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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Transglutaminase-2
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Transglutaminase-2" in MCE Product Catalog:
12
12 Publications Verification
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GK921 is a transglutaminase 2 (TGase) inhibitor with an IC50 of 7.71 μM for human recombinant TGase 2.
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ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor, with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD) [2].
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2 Cited Publications
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TG-2-IN-1 (Compound D003) is a transglutaminase-2 (TGM-2) inhibitor. TG-2-IN-1 can be used for the research of myopia .
Cat. No.: HY-P99512
CAS No.: 2098280-42-1
Synonyms: UCB-7858
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KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization [2].
Cat. No.: HY-177133
CAS No.: 2410912-75-1
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Suvigletistat is a Transglutaminase 2 (TG2) inhibitor with an IC50 <0.5 μM. Suvigletistat can be used for the research of inflammatory disorders .
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Thioredoxin reductase (TrxR) is a selenocysteine-containing NADPH-dependent disulfide oxidoreductase derived from rat liver that utilizes NADPH to reduce oxidized thioredoxin. Thioredoxin reductase can utilize the reducing capacity of human erythrocytes to study the uptake and reduction of α-Lipoic Acid (HY-N0492), and can also be used to investigate the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix using thioredoxin [2] .
Cat. No.: HY-162141
CAS No.: 2755794-94-4
MD102 is an orally active transglutaminase 2 (TG2) inhibitor with an IC50 of 0.35 μM. MD102 binds to the β-sandwich domain of TG2, disrupts the interaction between TG2 and p53, stabilizes p53, and reduces the activity of p-AKT and p-mTOR signaling pathways. MD102 induces cell apoptosis and inhibits tumor growth. MD102 can be used for the research of renal cell carcinoma .
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PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study .
Cat. No.: HY-100446
CAS No.: 815619-12-6
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NTU281 is a potent transglutaminase-2 inhibitor. NTU281 can reduce the increases in serum creatinine and albuminuria in diabetic rats. NTU281 can also reduce glomerular collagen I accumulation, Hic-5 and α-SMA expression, and apoptosis. NTU281 can be used for researching glomerulosclerosis caused by diabetes [2].
Cat. No.: HY-165426
CAS No.: 3031522-14-9
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HB-230 is a Transglutaminase-2 (TG2) (human IC50 = 4.9 μM) inhibitor and a selective fluorescent imaging probe for active TG2 localization. HB-230 modifies TG2 Cys277 to sustain the enzyme open conformation. HB-230 forms a ternary complex with TG2 and α2-macroglobulin, undergoes receptor-mediated endocytosis, and trafficks directly to lysosomes without early/late endosome fusion. HB-230 exhibits TG2 activity-dependent and α2-macroglobulin-dependent uptake. HB-230 can be used for the research of celiac disease, (Ex/Em = 649/665 nm) [2].
Cat. No.: HY-157975
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LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state .
Cat. No.: HY-P78361
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGM2; Transglutaminase C; Transglutaminase 2; Transglutaminase H; TGC; Transglutaminase-2; Protein-Glutamine Noradrenalinyltransferase TGM2; Heart G Alpha(H); Protein-Glutamine Gamma-Glutamyltransferase 2; HhG Alpha(H); Protein-Glutamine Histaminyltransfe
Species:
Mouse
Source:
E. coli
Cat. No.: HY-157254
CAS No.: 2134106-02-6
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AA10 is a potent and irreversible transglutaminase 2 (TG2) inhibitor for cancer research .
Cat. No.: HY-P76114Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGM2; Transglutaminase C; Transglutaminase 2; Transglutaminase H; TGC; Transglutaminase-2; Protein-Glutamine Noradrenalinyltransferase TGM2; Heart G Alpha(H); Protein-Glutamine Gamma-Glutamyltransferase 2; HhG Alpha(H); Protein-Glutamine Histaminyltransfe
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71132A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGM2; Transglutaminase C; Transglutaminase 2; Transglutaminase H; TGC; Transglutaminase-2; Protein-Glutamine Noradrenalinyltransferase TGM2; Heart G Alpha(H); Protein-Glutamine Gamma-Glutamyltransferase 2; HhG Alpha(H); Protein-Glutamine Histaminyltransfe
Species:
Mouse
Source:
HEK293
Cat. No.: HY-125958
CAS No.: 2134114-20-6
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AA9 is a potent Transglutaminase 2 (TG2) inhibitor. AA9 strongly impacts HIF-mediated hypoxia in MDA-MB-231 cells .
Cat. No.: HY-160132
CAS No.: 2410899-01-1
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TG-2-IN-4 (compound 8) is a transglutaminase 2 (TG2) inhibitor with an IC50 <0.5 mM. TG-2-IN-4 can be used for the research of inflammatory disorder .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
