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Pathways Recommended: Protein Tyrosine Kinase/RTK
Results for "

Tyrosine (Standard)

" in MedChemExpress (MCE) Product Catalog:

125

Inhibitors & Agonists

2

Peptides

23

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-50896R
    Erlotinib (Standard)

    CP-358774 (Standard); NSC 718781 (Standard); OSI-774 (Standard)

    		 Reference Standards EGFR Autophagy Cancer
    Erlotinib (Standard) is the analytical standard of Erlotinib. This product is intended for research and analytical applications. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Erlotinib (Standard)
  • HY-14596R
    Genistein (Standard)
    85+ Cited Publications

    NPI 031L (Standard)

    		 Reference Standards EGFR Autophagy Apoptosis Endogenous Metabolite Cancer
    Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.
    Genistein (Standard)
  • HY-N0473R
    L-Tyrosine (Standard)

    Tyrosine (Standard)

    		 Reference Standards Endogenous Metabolite Neurological Disease
    L-Tyrosine (Standard) is the analytical standard of L-Tyrosine. This product is intended for research and analytical applications. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
    L-Tyrosine (Standard)
  • HY-10981R
    Lenvatinib (Standard)

    E7080 (Standard)

    		 Reference Standards VEGFR FGFR PDGFR c-Kit RET Cancer
    Lenvatinib (Standard) is the analytical standard of Lenvatinib. This product is intended for research and analytical applications. Lenvatinib (E7080) is an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .
    Lenvatinib (Standard)
  • HY-10255R
    Sunitinib Malate (Standard)

    SU 11248 Malate (Standard)

    		 Reference Standards PDGFR VEGFR IRE1 Mitophagy Autophagy Apoptosis Cancer
    Sunitinib (Malate) (Standard) is the analytical standard of Sunitinib (Malate). This product is intended for research and analytical applications. Sunitinib Malate (SU 11248 Malate) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib Malate, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .
    Sunitinib Malate (Standard)
  • HY-50895R
    Gefitinib (Standard)

    ZD1839 (Standard)

    		 Reference Standards EGFR Autophagy Apoptosis Cancer
    Gefitinib (Standard) is the analytical standard of Gefitinib. This product is intended for research and analytical applications. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer .
    Gefitinib (Standard)
  • HY-113468AR
    3-O-Methyldopa (Standard)

    3-Methoxy-L-Tyrosine (Standard); 3-O-Methyl-L-DOPA (Standard)

    		 Drug Derivative Interleukin Related Reference Standards Neurological Disease Inflammation/Immunology
    3-O-Methyldopa (Standard) is the analytical standard of 3-O-Methyldopa. This product is intended for research and analytical applications. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine .
    3-O-Methyldopa (Standard)
  • HY-101474AR
    Zanubrutinib (Standard)

    BGB-3111 (Standard)

    		 Reference Standards Btk Cancer
    Zanubrutinib (Standard) is the analytical standard of Zanubrutinib. This product is intended for research and analytical applications. Zanubrutinib (BGB-3111) is a selective and orally active Bruton tyrosine kinase (Btk) inhibitor (IC50: 0.3 nM) .
    Zanubrutinib (Standard)
  • HY-N0737AR
    Harmine (Standard)

    Telepathine (Standard)

    		 Reference Standards DYRK 5-HT Receptor Neurological Disease Cancer
    Harmine (Standard) is the analytical standard of Harmine. This product is intended for research and analytical applications. Harmine is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM .
    Harmine (Standard)
  • HY-13223R
    Crenolanib (Standard)

    CP-868596 (Standard)

    		 FLT3 PDGFR Autophagy Reference Standards Cancer
    Crenolanib (Standard) is the analytical standard of Crenolanib. This product is intended for research and analytical applications. Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively.
    Crenolanib (Standard)
  • HY-B0607R
    Nitisinone (Standard)
    2 Publications Verification

    NTBC (Standard); Nitisone (Standard); SC0735 (Standard)

    		 HPPD Reference Standards Metabolic Disease
    Nitisinone (Standard) is the analytical standard of Nitisinone. This product is intended for research and analytical applications. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
    Nitisinone (Standard)
  • HY-113248R
    3-Nitro-L-tyrosine (Standard)

    		Endogenous Metabolite Reference Standards Cardiovascular Disease Inflammation/Immunology
    3-Nitro-L-tyrosine (Standard) is the analytical standard of 3-Nitro-L-tyrosine (HY-113248). This product is intended for research and analytical applications. 3-Nitro-L-tyrosine serves as a biomarker of oxidative stress. 3-Nitro-L-tyrosine attenuates the pressor and vasoconstrictive effects of angiotensin II by inhibiting the α1-adrenergic receptor-mediated signaling pathway, and participates in hemodynamic regulation under pathological conditions such as inflammation and ischemia. 3-Nitro-L-tyrosine can be used in studies related to atherosclerosis, ischemia-reperfusion and sepsis .
    3-Nitro-L-tyrosine (Standard)
  • HY-W012382R
    N-Acetyl-L-tyrosine (Standard)

    		Reference Standards Endogenous Metabolite Metabolic Disease Cancer
    N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine (HY-W012382). This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .
    N-Acetyl-L-tyrosine (Standard)
  • HY-10159R
    Nilotinib (Standard)

    AMN107 (Standard)

    		 Reference Standards Bcr-Abl Autophagy Cancer
    Nilotinib (Standard) is the analytical standard of Nilotinib. This product is intended for research and analytical applications. Nilotinib is an orally available Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.
    Nilotinib (Standard)
  • HY-N0198R
    Nordihydroguaiaretic acid (Standard)

    NDGA (Standard)

    		 Reference Standards Lipoxygenase Autophagy Ferroptosis Neurological Disease Cancer
    Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
    Nordihydroguaiaretic acid (Standard)
  • HY-33549R
    α-Methyl-p-tyrosine (Standard)

    		Tyrosine Hydroxylase Neurological Disease Cancer
    α-Methyl-p-tyrosine (Standard) is the analytical standard of α-Methyl-p-tyrosine. This product is intended for research and analytical applications. α-Methyl-p-tyrosine is a competitive inhibitor of tyrosine hydroxylase, which converts tyrosine into DOPA. α-Methyl-p-tyrosine is also an orally active inhibitor of catecholamine synthesis, inhibiting the hydroxylation of tyrosine into DOPA. α-Methyl-p-tyrosine can be used in research related to epilepsy, glaucoma, cancer, and other related diseases .
    α-Methyl-p-tyrosine (Standard)
  • HY-50946R
    Imatinib Mesylate (Standard)

    STI571 Mesylate (Standard); CGP-57148B Mesylate (Standard)

    		 Reference Standards c-Kit Bcr-Abl PDGFR Autophagy Cancer
    Imatinib (Mesylate) (Standard) is the analytical standard of Imatinib (Mesylate). This product is intended for research and analytical applications. Imatinib Mesylate (STI571 Mesylate) is an orally active tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.
    Imatinib Mesylate (Standard)
  • HY-10338R
    Foretinib (Standard)

    XL880 (Standard); GSK1363089 (Standard); GSK089 (Standard); EXEL-2880 (Standard)

    		 Reference Standards VEGFR c-Met/HGFR Cancer
    Foretinib (Standard) is the analytical standard of Foretinib. This product is intended for research and analytical applications. Foretinib is a multi-target tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.
    Foretinib (Standard)
  • HY-10260R
    Vandetanib (Standard)

    ZD6474 (Standard)

    		 Reference Standards VEGFR Autophagy Apoptosis Cancer
    Vandetanib (Standard) is the analytical standard of Vandetanib. This product is intended for research and analytical applications. Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
    Vandetanib (Standard)
  • HY-10981AR
    Lenvatinib mesylate (Standard)

    E7080 mesylate (Standard)

    		 Reference Standards VEGFR FGFR PDGFR RET c-Kit Cancer
    Lenvatinib (mesylate) (Standard) is the analytical standard of Lenvatinib (mesylate). This product is intended for research and analytical applications. Lenvatinib mesylate (E7080 mesylate), an oral, multi-targeted tyrosine kinase inhibitor that inhibits VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, shows potent antitumor activities .
    Lenvatinib mesylate (Standard)
  • HY-101957R
    AG 1295 (Standard)

    		Reference Standards PDGFR Cardiovascular Disease
    AG 1295 (Standard) is the analytical standard of AG 1295. This product is intended for research and analytical applications. AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR whereas not affects the autophosphorylation of the EGF receptor .
    AG 1295 (Standard)
  • HY-10065R
    Axitinib (Standard)

    AG-013736 (Standard)

    		 Reference Standards VEGFR PDGFR Cancer
    Axitinib (Standard) is the analytical standard of Axitinib. This product is intended for research and analytical applications. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.
    Axitinib (Standard)
  • HY-10205R
    Cediranib (Standard)

    AZD2171 (Standard)

    		 Reference Standards VEGFR Autophagy PDGFR Cancer
    Cediranib (Standard) is the analytical standard of Cediranib. This product is intended for research and analytical applications. Cediranib (AZD2171) is a highly potent, orally available VEGFR tyrosine kinase inhibitor with IC50s of <1, <3, 5, 5, 36, 2 nM for Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit, respectively.
    Cediranib (Standard)
  • HY-10255AR
    Sunitinib (Standard)

    SU 11248 (Standard)

    		 Reference Standards VEGFR PDGFR IRE1 Mitophagy Autophagy Apoptosis Cancer
    Sunitinib (Standard) is the analytical standard of Sunitinib. This product is intended for research and analytical applications. Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively . Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation .
    Sunitinib (Standard)
  • HY-15511R
    Tyrphostin A9 (Standard)

    Tyrphostin 9 (Standard); Malonoben (Standard)

    		 VEGFR Influenza Virus PDGFR Reference Standards Infection Cancer
    Tyrphostin A9 (Standard) is the analytical standard of Tyrphostin A9. This product is intended for research and analytical applications. Tyrphostin A9, a PDGFR inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst. Tyrphostin A9 has anti-influenza virus activities.
    Tyrphostin A9 (Standard)
  • HY-14435R
    Pyridone 6 (Standard)

    		JAK Reference Standards Cancer
    Pyridone 6 (Standard) is the analytical standard of Pyridone 6. This product is intended for research and analytical applications. Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC50s of 1 nM for JAK2 and TYK2, 5 nM for JAK3, and 15 nM for JAK1, while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.
    Pyridone 6 (Standard)
  • HY-15656R
    Ceritinib (Standard)

    LDK378 (Standard)

    		 Reference Standards Anaplastic lymphoma kinase (ALK) Insulin Receptor IGF-1R Metabolic Disease Inflammation/Immunology Cancer
    Ceritinib (Standard) is the analytical standard of Ceritinib (HY-15656). This product is intended for research and analytical applications. Ceritinib is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency .
    Ceritinib (Standard)
  • HY-50895AR
    Gefitinib hydrochloride (Standard)

    ZD-1839 hydrochloride (Standard)

    		 EGFR Reference Standards Cancer
    Gefitinib (hydrochloride) (Standard) is the analytical standard of Gefitinib (hydrochloride). This product is intended for research and analytical applications. Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity .
    Gefitinib hydrochloride (Standard)
  • HY-10207R
    Dovitinib lactate (Standard)

    CHIR-258 lactate (Standard); TKI-258 lactate (Standard)

    		 Reference Standards FLT3 c-Kit FGFR VEGFR PDGFR Cancer
    Dovitinib (lactate) (Standard) is the analytical standard of Dovitinib (lactate). This product is intended for research and analytical applications. Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively .
    Dovitinib lactate (Standard)
  • HY-10206R
    Amuvatinib (Standard)

    MP470 (Standard); HPK 56 (Standard)

    		 Reference Standards c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET Apoptosis Cancer
    Amuvatinib (Standard) is the analytical standard of Amuvatinib. This product is intended for research and analytical applications. Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair . Antineoplastic activity .
    Amuvatinib (Standard)
  • HY-10331R
    Regorafenib (Standard)

    BAY 73-4506 (Standard)

    		 Reference Standards VEGFR Autophagy PDGFR Raf RET c-Kit FGFR Tie Cancer
    Regorafenib (Standard) is the analytical standard of Regorafenib. This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib shows very robust antitumor and antiangiogenic activity .
    Regorafenib (Standard)
  • HY-10331AR
    Regorafenib monohydrate (Standard)

    BAY 73-4506 monohydrate (Standard)

    		 Reference Standards VEGFR Autophagy PDGFR Raf RET FGFR c-Kit Tie Cancer
    Regorafenib (monohydrate) (Standard) is the analytical standard of Regorafenib (monohydrate). This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity .
    Regorafenib monohydrate (Standard)
  • HY-W009592R
    Glycyl-L-tyrosine (Standard)

    GlycylTyrosine (Standard); Gly-Tyr (Standard); H-Gly-Tyr-OH (Standard)

    		 Amino Acid Derivatives Reference Standards Others
    Glycyl-L-tyrosine (Standard) is the analytical standard of Cyclic somatostatin. This product is intended for research and analytical applications. Glycyl-L-tyrosine is a synthetic dipeptide that can be used as a food additive for tyrosine supplementation .
    Glycyl-L-tyrosine (Standard)
  • HY-W041171R
    3-Chloro-L-tyrosine (Standard)

    3-ChloroTyrosine (Standard)

    		 Glutathione Peroxidase Reference Standards Others
    3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer .
    3-Chloro-L-tyrosine (Standard)
  • HY-W013293R
    Boc-D-Tyr-OH (Standard)

    		Amino Acid Derivatives Reference Standards Others
    Boc-D-Tyr-OH (Standard) is the analytical standard of Boc-D-Tyr-OH. This product is intended for research and analytical applications. Boc-D-Tyr-OH is a tyrosine derivative .
    Boc-D-Tyr-OH (Standard)
  • HY-101820R
    Simotinib (Standard)

    		Reference Standards EGFR Cancer
    Simotinib (Standard) is the analytical standard of Simotinib. This product is intended for research and analytical applications. Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities .
    Simotinib (Standard)
  • HY-10158AR
    Bosutinib hydrate (Standard)

    SKI-606 hydrate (Standard)

    		 Reference Standards Src Bcr-Abl Cancer
    Bosutinib (Standard) (SKI-606 (Standard)) hydrate is the analytical standard of Bosutinib hydrate (HY-10158A). This product is intended for research and analytical applications. Bosutinib hydrate is an oraly activel Src/Abl tyrosine kinase inhibito with IC50s of 1.2 nM and 1 nM, respectively.
    Bosutinib hydrate (Standard)
  • HY-117718R
    AG957 (Standard)

    Tyrphostin AG957 (Standard); NSC 654705 (Standard)

    		 Bcr-Abl Reference Standards Cancer
    AG957 (Standard) is the analytical standard of AG957. This product is intended for research and analytical applications. AG957 (Tyrphostin AG957;NSC 654705) is a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity . AG957 is a bcr/abl kinase inhibitor with an IC50 of 2.9 μM for p210bcr/abl autokinase activity .
    AG957 (Standard)
  • HY-10322R
    Falnidamol (Standard)

    BIBX 1382 (Standard)

    		 Reference Standards EGFR Cancer
    Falnidamol (Standard) is the analytical standard of Falnidamol. This product is intended for research and analytical applications. Falnidamol (BIBX 1382) is an orally active, selective EGFR tyrosine kinase inhibitor with an IC50 of 3 nM. Falnidamol displays > 1000-fold lower potency against ErbB2 (IC50=3.4 μM) and a range of other related tyrosine kinases (IC50>10 μM). Falnidamol is a pyrimido-pyrimidine compound and has anti-cancer activity .
    Falnidamol (Standard)
  • HY-10159AR
    Nilotinib monohydrochloride monohydrate (Standard)

    AMN107 monohydrochloride monohydrate (Standard)

    		 Reference Standards Bcr-Abl Autophagy Cancer
    Nilotinib (monohydrochloride monohydrate) (Standard) is the analytical standard of Nilotinib (monohydrochloride monohydrate). This product is intended for research and analytical applications. Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants.
    Nilotinib monohydrochloride monohydrate (Standard)
  • HY-50878R
    Crizotinib (Standard)

    PF-02341066 (Standard)

    		 Reference Standards Anaplastic lymphoma kinase (ALK) c-Met/HGFR ROS Kinase Autophagy Cancer
    Crizotinib (Standard) is the analytical standard of Crizotinib. This product is intended for research and analytical applications. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition .
    Crizotinib (Standard)
  • HY-108547R
    Alexidine dihydrochloride (Standard)

    		Fungal Apoptosis Infection Cancer
    Alexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .
    Alexidine dihydrochloride (Standard)
  • HY-12297R
    Sulfatinib (Standard)

    Surufatinib (Standard); HMPL-012 (Standard)

    		 Reference Standards FGFR VEGFR Cancer
    Sulfatinib (Standard) is the analytical standard of Sulfatinib. This product is intended for research and analytical applications. Sulfatinib (Surufatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM.
    Sulfatinib (Standard)
  • HY-50898R
    Lapatinib (Standard)

    GW572016 (Standard); GW2016 (Standard)

    		 Reference Standards EGFR Autophagy Ferroptosis Cancer
    Lapatinib (Standard) is the analytical standard of Lapatinib. This product is intended for research and analytical applications. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively .
    Lapatinib (Standard)
  • HY-10234AR
    Saracatinib difumarate (Standard)

    AZD0530 difumarate (Standard)

    		 Src Reference Standards Cancer
    Saracatinib (difumarate) (Standard) is the analytical standard of Saracatinib (difumarate). This product is intended for research and analytical applications. Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. .
    Saracatinib difumarate (Standard)
  • HY-101958R
    Tyrphostin 25 (Standard)

    AG82 (Standard); Tyrphostin A 25 (Standard); Tyrphostin AG 82 (Standard); RG-50875 (Standard)

    		 Reference Standards EGFR GPR35 Inflammation/Immunology Cancer
    Tyrphostin 25 (Standard) (AG82 (Standard)) is the analytical standard of Tyrphostin 25 (HY-101958). This product is intended for research and analytical applications. Tyrphostin 25 (AG82) is a specific inhibitor of the EGFR tyrosine kinase with an IC50 value of 3 µM in A431 cells. Tyrphostin 25 is also a GPR35 agonist with an EC50 of 5.3 µM .
    Tyrphostin 25 (Standard)
  • HY-13524R
    AG-1478 (Standard)

    Tyrphostin AG-1478 (Standard); NSC 693255 (Standard)

    		 EGFR HCV Influenza Virus Reference Standards Infection Cardiovascular Disease Metabolic Disease Cancer
    AG-1478 (Standard) is the analytical standard of AG-1478. This product is intended for research and analytical applications. AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).
    AG-1478 (Standard)
  • HY-13802R
    SC-514 (Standard)

    GK 01140 (Standard)

    		 IKK Reference Standards Cancer
    SC-514 (Standard) is the analytical standard of SC-514. This product is intended for research and analytical applications. SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.
    SC-514 (Standard)
  • HY-108330R
    AG126 (Standard)

    Tyrphostin AG126 (Standard)

    		 ERK Mitosis Reference Standards Inflammation/Immunology
    AG126 (Standard) is the analytical standard of AG126. This product is intended for research and analytical applications. AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .
    AG126 (Standard)
  • HY-W015007R
    Metyrosine (Standard)

    		Reference Standards COX Cardiovascular Disease
    Metyrosine (Standard) is the analytical standard of Metyrosine. This product is intended for research and analytical applications. Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity . Metyrosine is a very effective agent for blood pressure control .
    Metyrosine (Standard)

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