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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
VEGF-C
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "VEGF-C" in MCE Product Catalog:
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8 Publications Verification
MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR, IGF-1R and PDGFRβ. MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity .
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4 Cited Publications
Cat. No.: HY-N2187
CAS No.: 43043-74-9
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3 Cited Publications
VEGFR-3-IN-1 is a potent and selective VEGFR3 inhibitor with an IC50 of 110.4 nM. VEGFR-3-IN-1 significantly inhibits proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells by inactivating the VEGFR3 signaling pathway, and also effectively inhibits breast cancer growth .
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1 Cited Publications
Cat. No.: HY-P9920A
CAS No.: 947687-13-0
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1 Cited Publications
Cat. No.: HY-P990675
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Cat. No.: HY-152293
CAS No.: 1412453-70-3
EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC50=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Synonyms: OPT 302; VGX-300
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Cat. No.: HY-P3369
CAS No.: 2417491-82-6
Synonyms: AXT-107
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Cat. No.: HY-P99830
CAS No.: 1227158-72-6
Synonyms: KH902
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Cat. No.: HY-RS16674
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Vegfc Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vegfc gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-174508
Human VEGFC mRNA encodes the human vascular endothelial growth factor C (VEGFC) protein, a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. VEGFC promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels.
Cat. No.: HY-P11474
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Integrin FAK Akt ERK Interleukin Related TNF Receptor Bacterial Reactive Oxygen Species (ROS)
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Cat. No.: HY-RS15637
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VEGFC Human Pre-designed siRNA Set A contains three designed siRNAs for VEGFC gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
