2 Results for "

VGSC subtype

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "VGSC subtype" in MCE Product Catalog:

Cat. No.: HY-P1219
CAS No.: 925463-91-8
Synonyms: β-TRTX-Cj1α
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .
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Cat. No.: HY-126005
CAS No.: 2230472-55-4
Target:  

Sodium Channel

Research Areas:  

Cancer

VGSC blocker-1 is a potent and small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5). VGSC blocker-1 blocks INa peak currents 34.9% at 1 μM and inhibits cell invasion 0.3% at 1 μM in human breast cancer cell line MDA-MB-231, without affecting the cell viability .
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