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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
VISTA
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "VISTA" in MCE Product Catalog:
2
2 Cited Publications
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CA-170 is an orally delivered dual inhibitor of VISTA and PD-L1. CA-170 exhibits potent rescue of proliferation and effector functions of T cells inhibited by PD-L1/L2 and VISTA with selectivity over other immune checkpoint proteins as well as a broad panel of receptors and enzymes .
1
1 Cited Publications
Cat. No.: HY-P99040
CAS No.: 1969313-51-6
Synonyms: JNJ-61610588; CI-8993; VSTB112
1
1 Cited Publications
Cat. No.: HY-P991447
1
1 Cited Publications
Cat. No.: HY-P72428
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VSIR; V-Set Immunoregulatory Receptor; C10orf54; SISP1; VISTA; B7-H5; PD-1H; Dies1; GI24; B7H5; V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation; V-Set Domain-Containing Immunoregulatory Receptor; V-Domain Ig Suppressor Of T Cell Ac
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P990145
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Synonyms: Betamethasone 21-phosphate disodium salt; VISTA-Methasone
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Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt; Vista-Methasone) is a corticosteroid. Betamethasone disodium phosphate is used in research related to inflammatory and immune diseases such as keloids .
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VISTA-IN-2 (Compound 1) is an inhibitor of V-domain Ig suppressor of T-cell activation (VISTA). VISTA-IN-2 induces VISTA degradation in cells through an autophagic mechanism. VISTA-IN-2 rescues VISTA-mediated immunosuppression, and enhances antitumor activity of immune cells. VISTA-IN-2 also activates the antitumor immunity and inhibits tumor growth in a CT26 mouse model .
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NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM .
VISTA-IN-3 (Compound A4) is a potent VISTA small molecule inhibitor with a KD value of 0.49 μM. VISTA-IN-3 can induce the release of IFN-γ cytokines. VISTA-IN-3 synergistically enhances anti-cancer activity with PD-L1 antibody .
Cat. No.: HY-W014159
CAS No.: 55289-35-5
Cat. No.: HY-169853
CAS No.: 1189495-81-5
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M351-0056 is an orally active VISTA agonist with a Kd value of 12.60 μM. M351-0056 inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, and regulates type I interferon (IFN-I) and non-canonical NF-κB pathways. M351-0056 decreases the levels of cytokines (IFN-γ, IL-17A, TNF-α, IL-2 and IL-1β). M351-0056 improves imiquimod (HY-B0180)-induced psoriasis-like skin inflammation, reduces autoantibody levels, kidney damage and immune cell expansion in mice susceptible to chronic graft-versus-host disease and lupus, and delays the progression of systemic lupus erythematosus. M351-0056 can be used in research related to psoriasis-like dermatitis and systemic lupus erythematosus .
Cat. No.: HY-172396
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PD-L1/VISTA-IN-2 (Compound S8) is an orally active bifunctional PD-L1/VISTA inhibitor with an IC50 of 1.4 μM for PD-L1 and a KD of 2.1 μM for VISTA. PD-L1/VISTA-IN-2 can activate the tumor immune microenvironment and exert anti-cancer effects .
Cat. No.: HY-P11253
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Cat. No.: HY-170793
CAS No.: 2978623-09-3
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PD-L1/VISTA-IN-1 (Compound P17) is an orally active dual-target inhibitor of PD-L1 and VISTA. PD-L1/VISTA-IN-1 can block the PD-1/PD-L1 interaction (IC50: 0.1492 μM) and the VISTA pathway (KD: 0.2723 μM), thereby reactivating T cells. PD-L1/VISTA-IN-1 has anti-tumor activity .
Cat. No.: HY-13570CR
CAS No.: 151-73-5
Synonyms: Betamethasone 21-phosphate disodium salt (Standard); VISTA-Methasone (Standard)
Research Areas:
Betamethasone disodium phosphate (Standard) (Betamethasone 21-phosphate disodium salt (Standard); Vista-Methasone (Standard)) is the analytical standard of Betamethasone disodium phosphate. This product is intended for research and analytical applications. Betamethasone disodium phosphate (Betamethasone 21-phosphate disodium salt; Vista-Methasone) is a corticosteroid. Betamethasone disodium phosphate is used in research related to inflammatory and immune diseases such as keloids .
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INX-SM-56 is a cytotoxin that can be used for the synthesis of anti-VISTA antibody agent conjugate. VISTA: V-region Immunoglobulin-containing Suppressor of T cell Activation .
Cat. No.: HY-P11252
Research Areas:
Cat. No.: HY-P991421
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
