Search Result

Results for "

dopamine β-hydroxylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine β-hydroxylase (20) Adrenergic Receptor (2) Akt (2) Aldehyde Dehydrogenase (ALDH) (1) Antibiotic (2) Apoptosis (4) Bacterial (1) BCRP (2) Cytochrome P450 (2) Drug Derivative (1) Endogenous Metabolite (1) Environmental Pollutants (1) Fungal (1) Influenza Virus (2) Monoamine Oxidase (2) mTOR (2) NF-κB (2) P-glycoprotein (2) Phosphatase (1) PI3K (2) PKC (2) Reference Standards (3) Reverse Transcriptase (2) Telomerase (2) TGF-beta/Smad (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (14) Endocrinology (2) Infection (4) Metabolic Disease (3) Neurological Disease (3)

By Targets:

Dopamine β-hydroxylase (20)

Adrenergic Receptor (2)

Akt (2)

Aldehyde Dehydrogenase (ALDH) (1)

Antibiotic (2)

Apoptosis (4)

Bacterial (1)

BCRP (2)

Cytochrome P450 (2)

Drug Derivative (1)

Endogenous Metabolite (1)

Environmental Pollutants (1)

Fungal (1)

Influenza Virus (2)

Monoamine Oxidase (2)

mTOR (2)

NF-κB (2)

P-glycoprotein (2)

Phosphatase (1)

PI3K (2)

PKC (2)

Reference Standards (3)

Reverse Transcriptase (2)

Telomerase (2)

TGF-beta/Smad (2)

By Research Areas:

Cancer (6)

Cardiovascular Disease (14)

Endocrinology (2)

Infection (4)

Metabolic Disease (3)

Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Dopamine β-hydroxylase Dopamine Receptor Dopamine Transporter

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-N0453

Hypericin Maximum Cited Publications 8 Publications Verification	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-W017113

2-Mercaptobenzothiazole 1 Publications Verification	Environmental Pollutants Endogenous Metabolite	Metabolic Disease
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

HY-128483

Fusaric acid	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a **dopamine β-hydroxylase** inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-13289A

Nepicastat hydrochloride 3 Publications Verification SYN-117 hydrochloride; RS-25560-197 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
Nepicastat hydrochloride (SYN-117 hydrochloride) is a selective, potent, and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat hydrochloride produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat hydrochloride can cross the blood-brain barrier (BBB) .

HY-106004

Zamicastat BIA 5-1058	Dopamine β-hydroxylase P-glycoprotein BCRP	Cardiovascular Disease Cancer
Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC₅₀ values of 73.8 μM and 17.0 μM, respectively . Zamicastat reduces high blood pressure .

HY-122373

Coprine	Aldehyde Dehydrogenase (ALDH) Drug Derivative	Metabolic Disease
Coprine is an orally active disulfiram (HY-B0240)-like component and an inhibitor of aldehyde dehydrogenase. Coprine is isolated from Coprinus atranentarius. Coprine inhibits low K_m aldehyde dehydrogenase in rat liver and increases blood acetaldehyde levels during in vivo ethanol metabolism. Coprine does not inhibit semi-purified low K_m aldehyde dehydrogenase from rat liver in vitro. Coprine can be used in studies related to alcoholism .

HY-N0453R

Hypericin (Standard) Maximum Cited Publications 8 Publications Verification	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase	Infection Neurological Disease Cancer
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-13289

Nepicastat SYN117; RS-25560-197	Dopamine β-hydroxylase	Cardiovascular Disease
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .

HY-100796

Guanoclor Vatensol	Dopamine β-hydroxylase	Cardiovascular Disease
Guanoclor is an antihypertensive compound. Guanoclor is an adrenergic neurone-blocking agent, which also interferes with noradrenaline synthesis by inhibition of the enzyme dopamine beta-hydroxylase .

HY-14838A

Etamicastat hydrochloride BIA 5-453 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible *dopamine-β-hydroxylase* (DBH) inhibitor with an IC₅₀ value of 107 nM . Etamicastat can be used in the research of cardiovascular diseases .

HY-125796

U-14624	Dopamine β-hydroxylase	Neurological Disease
U-14624 is a potent and orally active **dopamine beta-hydroxylase** inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes .

HY-W204613

3-Allylphenol	Dopamine β-hydroxylase	Others
3-Allylphenol is an inhibitor of **dopamine β-hydroxylase with a K_i** value of 12 mM .

HY-148001

EWP 815	Phosphatase Dopamine β-hydroxylase	Others
EWP 815 is a disulfiram analogue, is a potent inhibitor of Ins(1,4)P₂ phosphatase and Ins(1,4,5)P₃ 5-phosphatase. EWP 815 also inhibits enzyme **dopamine β-hydroxylase** activity .

HY-14838

Etamicastat BIA 5-453	Dopamine β-hydroxylase	Cardiovascular Disease
Etamicastat (BIA 5-453) is a potent and reversible *dopamine-β-hydroxylase* (DBH) inhibitor with an IC₅₀ value of 107 nM . Etamicastat can be used in the research of cardiovascular diseases .

HY-126907

A32390A	Dopamine β-hydroxylase Bacterial	Infection Cardiovascular Disease Metabolic Disease
A32390A is a **dopamine β-hydroxylase inhibitor and copper chelator. A32390A can inhibit the synthesis of norepinephrine, which helps lower blood pressure in DOCA hypertensive rats. A32390A can be used in research on hypertension, bacterial** infections, and metabolic disorders .

HY-156989

Butobendine	Dopamine β-hydroxylase	Cardiovascular Disease
Butobendine, a double ester of 2-aminobutanol and trimethoxybenzoic acid, is an antiarrhythmic agent . Butobendine is a noncompetitive inhibitor of **dopamine β-hydroxylase (DBH**) .

HY-W1030828

SKF-102698	Dopamine β-hydroxylase	Cardiovascular Disease
SKF-102698 is a dopamine *β-hydroxylase* inhibitor. SKF 102698 increases endogenous dopamine levels. SKF-102698 can be used in hypertension research .

HY-13289B

(R)-Nepicastat hydrochloride (R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride	Dopamine β-hydroxylase	Cardiovascular Disease
(R)-Nepicastat hydrochloride is the isomer of Nepicastat (HY-13289). Nepicastat (SYN117) is a selective，potent，and orally active inhibitor of *dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC₅₀=8.5 nM) and human (IC₅₀=9 nM) dopamine-beta-hydroxylase*. Nepicastat (SYN117) can cross the blood-brain barrier (BBB) .

HY-116158

Oosponol	Dopamine β-hydroxylase Fungal	Infection Cardiovascular Disease
Oosponol is a **dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi** .

HY-128483R

Fusaric acid (Standard)	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor Reference Standards	Cardiovascular Disease Endocrinology Cancer
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a **dopamine β-hydroxylase** inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-165140

Dopastin	Others	Others
Dopastin is a compound that inhibits dopamine β-hydroxylase.

HY-182485

U-11634	Dopamine β-hydroxylase	Others
U-11634 is an orally active **dopamine β-hydroxylase noncompetitive inhibitor, with rat LD₅₀ values of 1197 mg/kg (subcutaneous) and 524 mg/kg (oral). U-11634 blocks conversion of dopamine to norepinephrine** and reduces norepinephrine levels in brain. U-11634 decreases food intake and spontaneous motor activity via dietary inclusion. U-11634 induces thyroid toxicity and inhibits pregnancy. U-11634 inhibits deciduomata formation in intact and steroid-treated rats, with no reversal by progesterone or oestradiol. U-11634 can be used for pregnancy .

HY-106004R

Zamicastat (Standard) BIA 5-1058 (Standard)	Reference Standards Dopamine β-hydroxylase P-glycoprotein BCRP	Cardiovascular Disease Cancer
Zamicastat (Standard) is the analytical standard of Zamicastat (HY-106004). This product is intended for research and analytical applications. Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC₅₀ values of 73.8 μM and 17.0 μM, respectively . Zamicastat reduces high blood pressure .

Hypericin Maximum Cited Publications 8 Publications Verification	Quinones Structural Classification Classification of Application Fields Anthraquinones Guttiferae Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

2-Mercaptobenzothiazole 1 Publications Verification	Structural Classification Natürliche Produkte Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC₅₀ value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .

Fusaric acid	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a **dopamine β-hydroxylase** inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

Hypericin (Standard) Maximum Cited Publications 8 Publications Verification	Natürliche Produkte Classification of Application Fields Guttiferae Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Source Classification Cancer	Reference Standards Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), *dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450*). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

Oosponol	Monophenols Microorganisms Phenols Source Classification	Dopamine β-hydroxylase Fungal
Oosponol is a **dopamine beta-hydroxylase inhibitor exhibiting hypotensive effects.Oospongol has strong antifungal activity against many antagonistic fungi** .

Fusaric acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor Reference Standards
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a **dopamine β-hydroxylase** inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

Art. -Nr.	Compare	Produktname	Species	Source	Image

HY-P76874

	Dopamine beta-Hydroxylase Protein, Human (HEK293, His) dopamine beta-hydroxylase; DBH; DOPBHY	Human	HEK293
	Dopamine beta-hydroxylase protein is an essential enzyme involved in the regulation of neurotransmitters. Its main function is to catalyze the hydroxylation of dopamine, converting it into norepinephrine (also known as norepinephrine). Dopamine beta-Hydroxylase Protein, Human (HEK293, His) is the recombinant human-derived Dopamine beta-Hydroxylase protein, expressed by HEK293 , with N-His labeled tag.

Compare Products


Products	Auf Lager - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / Auf Lager - + In den Warenkorb hinzufügen Angebot einholen

Art. -Nr.	Compare	Produktname	Application	Reactivity	Image

HY-P86857

	Dopamine beta Hydroxylase Antibody (YA6550) dbh antibody; DBM antibody; dopamine beta hydroxylase antibody; dopamine beta monooxygenase antibody; dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody; dopamine beta-monooxygenase antibody; DOPO_HUMAN antibody; OTTHUMP00000022501 antibody; Soluble dopamine beta-hydroxylase antibody;	WB	Human
	Dopamine beta Hydroxylase Antibody (YA6550) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Dopamine beta Hydroxylase.

Compare Products


Products	Auf Lager - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / Auf Lager - + In den Warenkorb hinzufügen Angebot einholen

Online-Anfrage

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Anrede			Country or Region *
Name des Antragstellers *			Name der Organisation *
Department *
E-Mail-Addresse *			Produktname *
Art. -Nr.			Requested quantity *
Telefonnummer *
Bemerkungen