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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
dot
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "dot" in MCE Product Catalog:
33
33 Publications Verification
Synonyms: EPZ-5676
Target:
Research Areas:
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.
13
13 Cited Publications
Target:
Research Areas:
SGC0946 is a selective DOT1L inhibitor with an IC50 value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells .
11
11 Cited Publications
Target:
Research Areas:
EPZ004777 is an effective and selective DOT1L inhibitor, with IC50 being 0.4 nM. EPZ004777 reduces the levels of H3K79me2 and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 can be used for the study of leukemia .
11
11 Cited Publications
Target:
Research Areas:
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor, with IC50 being 0.4 nM. EPZ004777 hydrochloride reduces the levels of H3K79me2 and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 hydrochloride selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 hydrochloride can be used for the study of leukemia .
7
7 Cited Publications
Cat. No.: HY-P70570
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Human
Source:
E. coli
5
5 Cited Publications
Cat. No.: HY-P73104
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
HEK293
4
4 Cited Publications
Cat. No.: HY-P73104A
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
HEK293
3
3 Cited Publications
Cat. No.: HY-P70274
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Human
Source:
HEK293
2
2 Cited Publications
Target:
Research Areas:
Mal-PEG4-NHS ester is a non-cleavable ADC linker which links Quantum dots (QDs) with PEGylated liposomes .
2
2 Cited Publications
Target:
Research Areas:
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 0.17 nM .
2
2 Cited Publications
Cat. No.: HY-P72797
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Human
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P73102
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Human
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P700182AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding Protein; Prev. HMG1; Amphoterin; High Mobility Group Protein B1; HMG-1; High Mobility Group Protein 1; Nuclear dot-Associated Sp100 Protein; SBP-1; Nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Target:
Research Areas:
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM .
1
1 Cited Publications
Cat. No.: HY-W127716
CAS No.: 136724-73-7
1
1 Cited Publications
Cat. No.: HY-W007671
CAS No.: 1080-06-4
Category:
Monophenols Other Diseases Phenols Amino acids Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-W012228
CAS No.: 3417-91-2
Target:
Research Areas:
H-Tyr-OMe.HCl is an amino acid derivative and also a coordinating ligand for Cu II ions. H-Tyr-OMe.HCl can serve as a surface functionalization reagent for carbon dots, and is used to prepare fluorescent probes for biothiol sensing. H-Tyr-OMe.HCl is oxidized to quinone under the catalysis of Tyrosinase via its phenolic hydroxyl group, which quenches the fluorescence of carbon dots. H-Tyr-OMe.HCl contains potential coordination sites, including carboxyl, amino and phenolic hydroxyl groups .
Target:
Research Areas:
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity .
Target:
Research Areas:
Dioctylamine (Di-n-octylamine) is a secondary amine that can be used in the seed-mediated growth synthesis of InAs quantum dots. Dioctylamine serves as an intermediate for constructing lipid nanoparticles .
Cat. No.: HY-101520A
Purity: 98.56%
Target:
Research Areas:
Dot1L-IN-1 TFA is a highly potent and selective Dot1L inhibitor with a Ki of 2 pM and an IC50 of <0.1 nM. Dot1L-IN-1 TFA potently suppresses H3K79 dimethylation (IC50=3 nM), as well as the activity of the HoxA9 promoter (IC50=17 nM) in HeLa and Molm-13 cells, respectively .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
