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Pathways Recommended:	Stem Cell/Wnt

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dried stems

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By Targets:	Drug Derivative (1) HBV (1) HIV (1) Parasite (1)
By Research Areas:	Cancer (2) Infection (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7369

Hybridaphniphylline A	Others	Others
Hybridaphniphylline A is a Alkaloids product that can be isolated from the dried stems and leaves of Daphniphyllum longeracemosum. .

HY-N7471

Daphnicyclidin I	Others	Others
Daphnicyclidin I is a Alkaloids product that can be isolated from the dried stems and leaves of Daphniphyllum longeracemosum. .

HY-N18013

Septemloside II	Others	Others
Septemloside II (Compound 6) is a triterpene saponin found in the dried stem bark of Kalopanax pictus (Kalopanacis Cortex) .

HY-N17557

Schizanrin D Schizarin D	HBV HIV	Infection
Schizanrin D (Schizarin D) is a C₁₈ Dibenzocyclooctadiene lignin. Schizanrin D can be derived from dried stems of Kadsura matsudai. Schizanrin D inhibits HBeAg production. Schizanrin D is inactive in vitro against HIV replication .

HY-N16875

Cincholic acid 3-O-β-D-quinovopyranoside	Drug Derivative	Others
Cincholic acid 3-O-β-D-quinovopyranoside is a natural triterpene.

HY-N16714

Clausine K	Others	Cancer
Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .

HY-N18294

(R,R)-Polysphorin	Parasite	Infection Cancer
(R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells .

Hybridaphniphylline A	Alkaloids Daphniphyllum longeracemosum Rosenth. Other Alkaloids Plants Source Classification	Others
Hybridaphniphylline A is a Alkaloids product that can be isolated from the dried stems and leaves of Daphniphyllum longeracemosum. .

Daphnicyclidin I	Alkaloids Daphniphyllum longeracemosum Rosenth. Pyrrole Alkaloids Plants Source Classification	Others
Daphnicyclidin I is a Alkaloids product that can be isolated from the dried stems and leaves of Daphniphyllum longeracemosum. .

Septemloside II	Structural Classification Terpenoids Kalopanax septemlobus (Thunb.) Koidz. Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Others
Septemloside II (Compound 6) is a triterpene saponin found in the dried stem bark of Kalopanax pictus (Kalopanacis Cortex) .

Schizanrin D Schizarin D	Structural Classification Lignans Kadsura japonica (L.) Dunal Phenylpropanoids Plants Schisandraceae Source Classification	HBV HIV
Schizanrin D (Schizarin D) is a C₁₈ Dibenzocyclooctadiene lignin. Schizanrin D can be derived from dried stems of Kadsura matsudai. Schizanrin D inhibits HBeAg production. Schizanrin D is inactive in vitro against HIV replication .

Cincholic acid 3-O-β-D-quinovopyranoside	Triterpenes Structural Classification Terpenoids Neonauclea sessilifolia (Roxb.) Merr. Rubiaceae Plants Source Classification	Drug Derivative
Cincholic acid 3-O-β-D-quinovopyranoside is a natural triterpene.

Clausine K	Structural Classification Alkaloids Pyrrole Alkaloids Rutaceae Plants Clausena excavata N. L. Burman Source Classification	Others
Clausine K is a carbazole alkaloid anticancer agent. Clausine K exhibits strong cytotoxicity against human hepatoma HepG2 cells (IC₅₀ = 1.05 μg/mL), superior to the standard drug Etoposide (HY-13629) (IC₅₀ 13.40 μg/mL). Clausine K can be naturally extracted from the dried stems of Clausena excavata (a plant of the Rutaceae family) through chromatographic separation and other methods .

(R,R)-Polysphorin	Structural Classification Araceae Ketones, Aldehydes, Acids Rhaphidophora decursiva (Roxb.) Schott Plants Source Classification	Parasite
(R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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dried stems

Inhibitors & Agonists

NaturalProducts

Natural
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