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ecdysone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (2) Calcium Channel (1) Caspase (2) Endogenous Metabolite (8) Environmental Pollutants (4) Fungal (1) Insecticide (14) Interleukin Related (1) Isotope-Labeled Compounds (2) MDM-2/p53 (3) Parasite (3) Reactive Oxygen Species (ROS) (1) Reference Standards (6)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (10) Inflammation/Immunology (1) Metabolic Disease (4) Neurological Disease (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6979

Crustecdysone Maximum Cited Publications 11 Publications Verification 20-Hydroxyecdysone	Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N0179

*Ecdysone* 1 Publications Verification α-ecdysone	Endogenous Metabolite Apoptosis	Metabolic Disease
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-117386

Methoxyfenozide 1 Publications Verification	Environmental Pollutants Insecticide	Infection
Methoxyfenozide is an orally active insecticide belonging to the diacylhydrazine and non-steroidal ecdysone agonist classes, which can interfere with the growth and development of insects. Methoxyfenozide has ovicidal and insecticidal activities against phytophagous pests .

HY-N1534

Ponasterone A 1 Publications Verification 25-Deoxyecdysterone	Others	Others
Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly .

HY-17533

Chromafenozide 1 Publications Verification ANS118	Insecticide	Infection
Chromafenozide is a potent partial ecdysone receptor agonist and dibenzoylhydrazine insecticide. Chromafenozide inhibits insect feeding and causes the insect to molt prematurely, leading to death. Chromafenozide shows antagonistic activity against 20-HE. Chromafenozide shows high toxicity against Spodoptera exigua and Spodoptera littoralis .

HY-B1331

Cyromazine Cyromazin; CGA-72662	Environmental Pollutants Endogenous Metabolite Parasite	Neurological Disease Metabolic Disease
Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-B2054

Tebufenozide	Environmental Pollutants Insecticide MDM-2/p53 Apoptosis	Cancer
Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells .

HY-16785

Veledimex INXN-1001; RG-115932	Interleukin Related	Inflammation/Immunology Cancer
Veledimex (INXN-1001), a synthetic analog of the insect molting hormone ecdysone, is an orally active activator ligand for a proprietary gene therapy promoter system. Veledimex can be used to activate certain genes using the ecdysone receptor (EcR)-based inducible gene regulation system, the RheoSwitch Therapeutic System (RTS). Veledimex can cross blood-brain barrier (BBB) in both orthotopic GL-261 mice and cynomolgus monkeys .

HY-103273

Muristerone A	Endogenous Metabolite	Others
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a K_d of 1 nM .

HY-113890

Halofenozide RH-0345	Environmental Pollutants	Others
Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone .

HY-129671

Polypodine B 5β-Hydroxyecdysterone	Parasite Fungal	Infection
Polypodine B is a natural ecdysone ester isolated from the bark of Dacrydium intermedium. Polypodine B significantly inhibits the activity of *Acanthamoeba castellani. Polypodine B has moderate antifungal* activity. Polypodine B can be used for research on parasitic diseases and fungal infections .

HY-W339331

Flubendiamide NNI-0001	Insecticide Calcium Channel Reactive Oxygen Species (ROS) Apoptosis	Infection Metabolic Disease
Flubendiamide (NNI-0001) is an orally active phthalic diamide insecticide that acts by targeting insect ryanodine receptors (RyRs), causing insect muscle dysfunction, paralysis and death. Flubendiamide disrupts molting, metamorphosis and reproductive processes, induces oxidative stress by increasing the levels of ROS/RNS, MDA and 8OHdG and decreasing the levels of SOD, CAT and GST, activates the CncC/Maf apoptosis pathway, impairs calcium homeostasis, promotes adipogenesis, increases triglyceride accumulation, and upregulates the expression of regulatory factors for adipocyte differentiation and adipogenesis .

HY-114636

RG-102240	Insecticide	Others
RG-102240 is a ligand for insect ecdysone receptor (EcR), with IC₅₀ of 85 and 13 nM, in wildtype G:CfE(DEF) and its A110P mutant. RG-102240 induces the reporter gene activity of wild-type CfEcR and A110P mutant .

HY-117386S

Methoxyfenozide-d9	Isotope-Labeled Compounds Insecticide	Infection
Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide (HY-117386). Methoxyfenozide is an orally active insecticide belonging to the diacylhydrazine and non-steroidal ecdysone agonist classes, which can interfere with the growth and development of insects. Methoxyfenozide has ovicidal and insecticidal activities against phytophagous pests .

HY-N6979R

Crustecdysone (Standard) 20-Hydroxyecdysone (Standard)	Reference Standards Caspase Autophagy Endogenous Metabolite	Cardiovascular Disease
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-W750355

Azadirachtin D	Insecticide	Infection
Azadirachtin D is an insect growth regulator targeting ecdysone receptor (EcR) in insects. Azadirachtin D blocks the 20-hydroxyecdysone signaling pathway, leading to developmental arrest or death in insects. Azadirachtin D is promising for research of agricultural pests .

HY-B2054S

Tebufenozide-d9	Isotope-Labeled Compounds Apoptosis Insecticide MDM-2/p53	Cancer
Tebufenozide-d₉ is the deuterium labeled Tebufenozide (HY-B2054). Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells .

HY-117386R

Methoxyfenozide (Standard)	Reference Standards Insecticide	Infection
Methoxyfenozide (Standard) is the analytical standard of Methoxyfenozide (HY-117386). This product is intended for research and analytical applications. Methoxyfenozide is an orally active insecticide belonging to the diacylhydrazine and non-steroidal ecdysone agonist classes, which can interfere with the growth and development of insects. Methoxyfenozide has ovicidal and insecticidal activities against phytophagous pests.

HY-B2054R

Tebufenozide (Standard)	Reference Standards Apoptosis Insecticide MDM-2/p53	Cancer
Tebufenozide (Standard) is the analytical standard of Tebufenozide (HY-B2054). This product is intended for research and analytical applications. Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells .

HY-N16479

Azadirachtin I	Insecticide	Infection
Azadirachtin I is an insecticide targeting insect growth and development-related pathways (e.g., ecdysone signaling pathway, chitin synthesis pathway). Azadirachtin I inhibits chitin synthesis and disrupting intestinal function by interfering with the growth and development processes of insect larvae such as molting and pupation, increasing insect mortality and reducing adult fecundity. Azadirachtin I is promising for research of agricultural pests, such as Lepidoptera, Coleoptera .

HY-17533R

Chromafenozide (Standard) ANS118 (Standard)	Insecticide Reference Standards	Infection
Chromafenozide (Standard) is the analytical standard of Chromafenozide. This product is intended for research and analytical applications. Chromafenozide is a potent partial ecdysone receptor agonist and dibenzoylhydrazine insecticide. Chromafenozide inhibits insect feeding and causes the insect to molt prematurely, leading to death. Chromafenozide shows antagonistic activity against 20-HE. Chromafenozide shows high toxicity against Spodoptera exigua and Spodoptera littoralis .

HY-B1331R

Cyromazine (Standard) Cyromazin (Standard); CGA-72662 (Standard)	Reference Standards Endogenous Metabolite Parasite	Neurological Disease Metabolic Disease
Cyromazine (Standard) is the analytical standard of Cyromazine. This product is intended for research and analytical applications. Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-113890R

Halofenozide (Standard) RH-0345 (Standard)	Others Reference Standards	Others
Halofenozide (Standard) is the analytical standard of Halofenozide. This product is intended for research and analytical applications. Halofenozide (RH-0345) is an ecdysteroid agonist. RH-0345 belongs to a new group of insect growth regulators (IGRs) with a benzoylhydrazine structure that mimic the action of the natural insect molting hormone 20-hydroxyecdysone .

HY-158327

Insecticidal agent 9	Insecticide	Others
Insecticidal agent 9 (Compound I-17) is an insecticide with good insecticidal activity. Insecticidal agent 9 has LC₅₀ values of 93.32 mg/L and 114.79 mg/L against Plutella xylostella and Ostrinia furnacalis respectively, and exhibits a mortality rate of up to 86.1% against Spodoptera frugiperda at a concentration of 500 mg/L. Insecticidal agent 9 can act simultaneously on the ecdysone receptor (EcR) and three chitinases (OfChtI, OfChtII, and OfChi-h), demonstrating good binding activity (to EcR) and inhibitory rates (to the three chitinases). Insecticidal agent 9 can be used in research for pest management .

HY-118989

Ajugalactone	Insecticide Endogenous Metabolite	Infection
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both *ecdysone* (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

HY-N15491

2-Deoxyecdysone	Endogenous Metabolite	Others
2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6979

Crustecdysone Maximum Cited Publications 11 Publications Verification 20-Hydroxyecdysone	Cardiovascular Disease other families Animals Classification of Application Fields Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Disease Research Fields Steroids Source Classification	Caspase Autophagy Endogenous Metabolite
Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-N0179

*Ecdysone* 1 Publications Verification α-ecdysone	Animals Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Apoptosis
Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E; HY-N6979) .

HY-N1534

Ponasterone A 1 Publications Verification 25-Deoxyecdysterone	Podocarpus nakaii Hayata Classification of Application Fields Other Diseases Podocarpaceae Plants Disease Research Fields Steroids Source Classification	Others
Ponasterone A (25-Deoxyecdysterone), an ecdysteroid, has strong affinity for the ecdysone receptor. Ponasterone A is a potent regulator of gene expression in cells and transgenic animals, enabling reporter genes to be turned on and off rapidly .

HY-B1331

Cyromazine Cyromazin; CGA-72662	Structural Classification Natural Products Endogenous metabolite Source Classification	Environmental Pollutants Endogenous Metabolite Parasite
Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-103273

Muristerone A	Ipomoea nil (Linnaeus) Roth Classification of Application Fields Other Diseases Plants Convolvulaceae Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Muristerone A is a phytoecdysteroid analog of ecdysone and a potent agonist of ecdysteroid receptor with a K_d of 1 nM .

HY-N6979R

Crustecdysone (Standard) 20-Hydroxyecdysone (Standard)	Structural Classification other families Animals Plants Compositae Endogenous metabolite Canavalia gladiata (Jacq.) DC. Steroids Source Classification	Reference Standards Caspase Autophagy Endogenous Metabolite
Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .

HY-W750355

Azadirachtin D	Structural Classification Tetracyclic Triterpenoids Terpenoids Azadirachta indica A. Juss. Plants Meliaceae Source Classification	Insecticide
Azadirachtin D is an insect growth regulator targeting ecdysone receptor (EcR) in insects. Azadirachtin D blocks the 20-hydroxyecdysone signaling pathway, leading to developmental arrest or death in insects. Azadirachtin D is promising for research of agricultural pests .

HY-N16479

Azadirachtin I	Structural Classification Tetracyclic Triterpenoids Terpenoids Azadirachta indica A. Juss. Plants Meliaceae Source Classification	Insecticide
Azadirachtin I is an insecticide targeting insect growth and development-related pathways (e.g., ecdysone signaling pathway, chitin synthesis pathway). Azadirachtin I inhibits chitin synthesis and disrupting intestinal function by interfering with the growth and development processes of insect larvae such as molting and pupation, increasing insect mortality and reducing adult fecundity. Azadirachtin I is promising for research of agricultural pests, such as Lepidoptera, Coleoptera .

HY-B1331R

Cyromazine (Standard) Cyromazin (Standard); CGA-72662 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Parasite
Cyromazine (Standard) is the analytical standard of Cyromazine. This product is intended for research and analytical applications. Cyromazine (CGA-72662) is a triazine insect growth regulator used as an insecticide and an acaricide. It is a cyclopropyl derivative of melamine. Cyromazine works by affecting the nervous system of the immature larval stages of certain insects. Cyromazine reduced the number of germ cells by interfering with the Ecdysone (HY-N0179) signaling pathway. Cyromazine induces renal toxicity attenuated and restored by green tea extract in rats .

HY-118989

Ajugalactone	Structural Classification Labiatae Plants Steroids Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Insecticide Endogenous Metabolite
Ajugalactone is a phytoecdysteroid found in plants of the Ajuga genus. Ajugalactone shows both *ecdysone* (HY-N0179) agonist activity and anti‑ponasterone A (HY-N1534) antagonist activity. Ajugalactone significantly disrupts insect molting and developmental processes. Ajugalactone acts as an insect growth regulator that interferes with insect molting. Ajugalactone induces complete mortality in first‑instar larvae of the greenhouse whitefly. Ajugalactone can be used for research on insect‑plant interactions and insect growth regulation .

HY-N15491

2-Deoxyecdysone	Structural Classification Natural Products Animals Steroids Source Classification	Endogenous Metabolite
2-Deoxyecdysone is a circulating ecdysteroid found in Z. atratus and functions as a prohormone during the development of some insects .

Cat. No.	Product Name	Chemical Structure

HY-117386S

Methoxyfenozide-d9
Methoxyfenozide-d₉ is the deuterium labeled Methoxyfenozide (HY-117386). Methoxyfenozide is an orally active insecticide belonging to the diacylhydrazine and non-steroidal ecdysone agonist classes, which can interfere with the growth and development of insects. Methoxyfenozide has ovicidal and insecticidal activities against phytophagous pests .

HY-B2054S

Tebufenozide-d9
Tebufenozide-d₉ is the deuterium labeled Tebufenozide (HY-B2054). Tebufenozide is a nonsteroidal ecdysone agonist used to control pest. Tebufenozide has cytotoxic and induces apoptosis in HeLa and insect Tn5B1-4 cells .

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ecdysone

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