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Results for "

fluorogenic peptide substrate

" in MedChemExpress (MCE) Product Catalog:

30

Inhibitors & Agonists

5

Fluorescent Dye

26

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P5354
    FRETS-VWF73
    1 Publications Verification

    		 Fluorescent Dye Cardiovascular Disease
    FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). FRETS-VWF73 is a predictive tool for thrombotic thrombocytopenic purpura .
    FRETS-VWF73
  • HY-D1705
    Ac-ANW-AMC

    		Proteasome Inflammation/Immunology
    Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) .
    Ac-ANW-AMC
  • HY-P2295
    Dabcyl-KTSAVLQSGFRKME-Edans TFA
    2 Publications Verification

    		 SARS-CoV Others
    Dabcyl-KTSAVLQSGFRKME-Edans TFA is a fluorogenic peptide. Dabcyl-KTSAVLQSGFRKME-Edans TFA is used as the substrate to measure the enzymatic activities of protease forms. Dabcyl-KTSAVLQSGFRKME-Edans TFA has the potential for study 2019-nCoV (COVID-19) infection .
    Dabcyl-KTSAVLQSGFRKME-Edans TFA
  • HY-P1883A
    Bacterial Sortase Substrate III, Abz/DNP TFA

    		Fluorescent Dye Infection
    Bacterial Sortase Substrate III, Abz/DNP TFA is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP TFA undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .
    Bacterial Sortase Substrate III, Abz/DNP TFA
  • HY-P1986
    Z-DEVD-AFC

    		Caspase Cancer
    Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
    Z-DEVD-AFC
  • HY-P4425
    Gly-Phe-AMC

    		Biochemical Assay Reagents Others
    Gly-Phe-AMC is a fluorogenic peptide substrate consisting of a peptide sequence composed of glycine and phenylalanine, linked to the fluorophore AMC. Gly-Phe-AMC also serves as a cathepsin C substrate. Gly-Phe-AMC is widely used to detect the activity of various proteases .
    Gly-Phe-AMC
  • HY-142021
    Z-Leu-Arg-AMC

    		Cathepsin Parasite Infection Inflammation/Immunology
    Z-Leu-Arg-AMC is a fluorogenic peptide substrate for cysteine proteases (e.g., Cathepsin) (Ex=350 nm，Em=460 nm). Z-Leu-Arg-AMC is preferentially cleaved by Cathepsin K and S under weakly acidic conditions, while its hydrolysis relies on residual Cathepsin S activity at neutral pH. Z-Leu-Arg-AMC serves as a substrate for recombinant Sphenophorus levis Cathepsin L, falcipain-2, falcipain-3, berghepain-2, knowlepain-2, vivapain-2, as well as falcipain-2 chimeras and constructs. It enables quantitative detection of cysteine protease activity in human inflammatory bronchoalveolar lavage fluid via fluorescence generation. Z-Leu-Arg-AMC can be used in research related to pulmonary inflammatory diseases and malaria .
    Z-Leu-Arg-AMC
  • HY-148073
    MeO-Succ-Arg-Pro-Tyr-AMC TFA

    		Fluorescent Dye Ser/Thr Protease Others
    MeO-Succ-Arg-Pro-Tyr-AMC TFA is a fluorogenic peptide substrate for chymotrypsin-like proteases that detects protease activity . (measured at 460 nm)
    MeO-Succ-Arg-Pro-Tyr-AMC TFA
  • HY-P5354A
    FRETS-VWF73 TFA
    1 Publications Verification

    		 Fluorescent Dye Others
    FRETS-VWF73 TFA, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm) .
    FRETS-VWF73 TFA
  • HY-P2008
    Boc-Ile-Glu-Gly-Arg-AMC
    1 Publications Verification

    IEGR-AMC

    		 Factor Xa Cardiovascular Disease
    Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is an activated factor X (FXa) specific fluorogenic peptide substrate used for Factor VIII determination .
    Boc-Ile-Glu-Gly-Arg-AMC
  • HY-P2536
    Mca-Ala-Pro-Lys(Dnp)-OH
    2 Publications Verification

    		 Angiotensin-converting Enzyme (ACE) Others
    Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .
    Mca-Ala-Pro-Lys(Dnp)-OH
  • HY-155667A
    Z-Nle-Lys-Arg-AMC acetate

    		Cathepsin Others
    Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
    Z-Nle-Lys-Arg-AMC acetate
  • HY-P3115
    Ac-LEVD-AFC

    		Fluorescent Dye Biochemical Assay Reagents Others
    Ac-LEVD-AFC is capspase-4 fluorogenic substrate peptide that can be used for caspase-4 activity studies .
    Ac-LEVD-AFC
  • HY-P4341A
    D-Val-Leu-Lys-AMC TFA

    		PAI-1 Fluorescent Dye Others
    D-Val-Leu-Lys-AMC TFA is a selective fluorogenic peptide substrate of plasmin. D-Val-Leu-Lys-AMC TFA can be used for the quantification of enzymatic activity of plasmin. Ex: 360-380 nm, Em: 440-460 nm .
    D-Val-Leu-Lys-AMC TFA
  • HY-P1448
    Ac-Leu-Arg-AMC

    		Fluorescent Dye Neurological Disease
    Ac-Leu-Arg-AMC is a fluorogenic peptide substrate.
    Ac-Leu-Arg-AMC
  • HY-P5272
    Histatin-3 TFA

    		Bacterial Inflammation/Immunology
    Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM .
    Histatin-3 TFA
  • HY-P4341
    D-Val-Leu-Lys-AMC

    		PAI-1 Fluorescent Dye Others
    D-Val-Leu-Lys-AMC is a selective fluorogenic peptide substrate of plasmin. D-Val-Leu-Lys-AMC can be used for the quantification of enzymatic activity of plasmin. Ex: 360-380 nm, Em: 440-460 nm .
    D-Val-Leu-Lys-AMC
  • HY-155667
    Z-Nle-Lys-Arg-AMC

    		Cathepsin Fluorescent Dye Others
    Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
    Z-Nle-Lys-Arg-AMC
  • HY-P1883
    Bacterial Sortase Substrate III, Abz/DNP

    		Fluorescent Dye Infection
    Bacterial Sortase Substrate III, Abz/DNP is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .
    Bacterial Sortase Substrate III, Abz/DNP
  • HY-120659
    Gly-Gly-AMC

    		Fluorescent Dye Others
    Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
    Gly-Gly-AMC
  • HY-P10163
    α-Secretase Substrate II, Fluorogenic

    		Fluorescent Dye Others
    α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm
    α-Secretase Substrate II, Fluorogenic
  • HY-P4334
    Bz-RGFFL-4MβNA

    Bz-Arg-Gly-Phe-Phe-Leu-4MβNA

    		 Fluorescent Dye Others
    Bz-RGFFL-4MβNA (Bz-Arg-Gly-Phe-Phe-Leu-4MβNA) is a peptide and can be used fluorogenic substrate .
    Bz-RGFFL-4MβNA
  • HY-P4403
    Z-DEVD-R110

    (Z-Asp-Glu-Val-Asp)₂-Rhodamine 110

    		 Fluorescent Dye Apoptosis Caspase Others
    Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp)2-Rhodamine 110) is a fluorogenic caspase-3/7 substrate. Z-DEVD-R110 can be used to detect apoptosis. Z-DEVD-R110 is a rhodamine derivative with two four–amino acid (DEVD) peptides linked to the fuorophore .
    Z-DEVD-R110
  • HY-P4366
    Tos-Gly-Pro-Lys-AMC

    		Ser/Thr Protease Others
    Tos-Gly-Pro-Lys-AMC is a fluorogenic peptide substrate of tryptase .
    Tos-Gly-Pro-Lys-AMC
  • HY-P4899
    β-Secretase substrate VI, fluorogenic

    RE(EDANS)EVNLDAEFK(DABCYL)R

    		 Beta-secretase Neurological Disease
    β-Secretase substrate VI, fluorogenic is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). β-Secretase substrate VI, fluorogenic can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction .
    β-Secretase substrate VI, fluorogenic
  • HY-P4209A
    Boc-GRR-AMC TFA

    		Virus Protease Others
    Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
    Boc-GRR-AMC TFA
  • HY-P11081
    P08

    		Enterovirus Infection
    P08 is a substrate for EV71 3C protease cleavage with a Kcat/Km of 11.8 mM −1 min −1 .
    P08
  • HY-P5415
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS

    		HIV Others
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-Kd protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
    DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS
  • HY-P11425
    Dabcyl-GLRTQSFS-EDANS

    		Fluorescent Dye Infection
    Dabcyl-GLRTQSFS-EDANS is a fluorogenic peptide substrate. Dabcyl-GLRTQSFS-EDANS can be used to measure the enzymatic activities of Hepatitis A Virus 3C proteinase .
    Dabcyl-GLRTQSFS-EDANS
  • HY-P3364A
    Ac-QPKK(Ac)-AMC acetate

    		Fluorescent Dye Sirtuin HDAC Others
    Ac-QPKK(Ac)-AMC acetate is a p53-derived peptide conjugated with a fluorophore, which serves as a fluorescent peptide substrate for detecting the deacylase activity of zinc-dependent HDACs and sirtuins (Ex = 360 nm; Em = 460 nm) .
    Ac-QPKK(Ac)-AMC acetate

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