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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
frameshift
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "frameshift" in MCE Product Catalog:
1
Target:
Research Areas:
VVD-130037 (BAY-3605349) is a covalent molecular glue and allosteric NRF2 degrader. VVD-130037 covalently binds to KEAP1 and allosterically enhances the affinity of KEAP1-CUL3, promotes the formation of the active KEAP1-CUL3 E3 ligase complex, and thereby enhances the ubiquitination and degradation of NRF2. VVD-130037 exhibits KEAP1 target-binding activity both in in vitro systems and mouse models, and it can be used in research related to NRF2-dependent cancers, solid tumors harboring KEAP1 nonsense mutations and frameshift mutations, as well as advanced solid tumors .
1
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria .
Cat. No.: HY-W127746
CAS No.: 550-74-3
Research Areas:
Picrolonic acid is a nematode hatching agent and bacterial frameshift mutagen. Picrolonic acid induces egg hatching in various nematodes. Picrolonic acid induces frameshift mutations in Salmonella. Picrolonic acid preferentially inhibits the growth of DNA polymerase-deficient E. coli . Picrolonic acid also serves as an analytical reagent for the determination of calcium, magnesium, lead, strontium, and thorium, and for the analysis of alkaloids, tryptophan, and phenylalanine. Picrolonic acid is used in research related to bacterial and parasitic infections .
Cat. No.: HY-W728005
CAS No.: 1225177-95-6
Covidcil-19 (compound C5) avidly binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with a Kd of 11 nM. Covidcil-19 stabilizes the hairpin’s folded state and impairs frameshifting in cells. Covidcil-19 reduces frameshifting efficiency of the SARS-CoV-2 FSE and does not affect SARS-CoV-2 FSE RNA levels. Covidcil-19 inhibits a process essential for SARS-CoV-2 viral propagation .
Cat. No.: HY-157848
CAS No.: 924058-34-4
SARS-CoV-2-IN-82 (compound A) is a Programmed-1 ribosomal frameshift (-1 PRF) inhibitor of SARS-CoV-2 .
Cat. No.: HY-173081
4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin (Compound 2d) is a broad-spectrum anti-coronaviral agent via targeting frameshifting element (FSE). 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin inhibits HCoV-OC43 and HCoV-229E with EC50 values of 0.85 μM and 1.45 μM. 4"-(2-(p-Chlorophenyl)acetoxyl)spiramycin shows a dual-target mechanism that acts on both viral FSE RNA and host DIS3L2 .
Cat. No.: HY-P706122
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: C4B; Basic Complement C4; Complement C4B (Chido/Rodgers Blood Group); Complement C4B1a; CPAMD3; Complement C4-B; C4B1; C4B5; C4B3; Complement Component 4B (Chido/Rodgers Blood Group), Copy 2; CO4; Complement Protein C4B frameshift Mutant; C4F; Chido Form
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
