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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
fusion loop
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "fusion loop" in MCE Product Catalog:
Synonyms: Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride
Target:
Drug Metabolite Atg8/LC3 p62 Atg7 MDM-2/p53 PAK Caspase PARP TNF Receptor Parasite Bacterial Autophagy Apoptosis
Domaines de recherche:
N-Desmethyl clomipramine hydrochloride (Desmethylclomipramine hydrochloride; Norclomipramine hydrochloride) is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine hydrochloride blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine hydrochloride inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine hydrochloride can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis .
Cat. No.: HY-P991450
Synonyms: ADI-15742; MBP-134 AF
ADI-15878 (ADI-15742; MBP-134 AF) is an Ebola virus GP-binding antibody. ADI-15878 blocks GP-mediated membrane fusion and viral entry by binding to a conserved, non-overlapping epitope comprising the GP1 N-terminal pocket and the GP2 fusion loop. As a component of MBP134, ADI-15878 targets an epitope conserved in BDBV sequences, supporting cross-species activity against EBOV and BDBV, and can be used in combination with ADI-15946 and/or CA45 for next-generation monoclonal antibody cocktail therapy. ADI-15878 can be used for research on Bundibugyo virus disease and Ebola virus disease .
Cat. No.: HY-149125
CAS No.: 71965-57-6
Synonyms: Ceramide trihexosides (porcine)
Target:
Domaines de recherche:
Globotriaosylceramide porcine RBC (Ceramide trihexosides porcine) is a neutral glycosphingolipid belonging to the globoside series of erythrocytes, primarily isolated and extracted from porcine RBC. Globotriaosylceramide porcine RBC is a natural resistance factor against HIV-1 infection. Globotriaosylceramide porcine RBC blocks viral binding to CXCR4/CCR5 co-receptors through competitive binding to the V3 loop region of HIV-1 gp120, thereby inhibiting viral fusion and entry. Globotriaosylceramide porcine RBC is the major cell surface receptor for Shiga toxin. Globotriaosylceramide porcine RBC can be used for research on hemolytic uremic syndrome, HIV-1 infection, and Fabry disease .
Category:
Synonyms: Desmethylclomipramine-d3 hydrochloride；Norclomipramine-d3 hydrochloride
Target:
Isotope-Labeled Compounds Drug Metabolite Atg8/LC3 p62 Atg7 MDM-2/p53 PAK Caspase PARP TNF Receptor Parasite Bacterial Autophagy Apoptosis
Domaines de recherche:
N-Desmethyl clomipramine-d3 hydrochloride (Desmethylclomipramine-d3 hydrochloride; Norclomipramine-d3 hydrochloride) is the deuterated-labeled N-Desmethyl clomipramine hydrochloride (HY-12388A). N-Desmethyl clomipramine hydrochloride is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine hydrochloride blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine hydrochloride inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine hydrochloride can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis .
Cat. No.: HY-174536
Human TFE3 mRNA encodes the human transcription factor binding to IGHM enhancer 3 (TFE3) protein, a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences. TFE3 may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins.
Cat. No.: HY-12388AR
CAS No.: 29854-14-6
Synonyms: Desmethylclomipramine hydrochloride (Standard); Norclomipramine hydrochloride (Standard)
Target:
Reference Standards Drug Metabolite Atg8/LC3 p62 Atg7 MDM-2/p53 PAK Caspase PARP TNF Receptor Parasite Bacterial Autophagy Apoptosis
Domaines de recherche:
N-Desmethyl clomipramine hydrochloride (Standard) (Desmethylclomipramine hydrochloride (Standard); Norclomipramine hydrochloride (Standard)) is the analytical standard of N-Desmethyl clomipramine hydrochloride (HY-12388A). This product is intended for research and analytical applications. N-Desmethyl clomipramine hydrochloride is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine hydrochloride blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine hydrochloride inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine hydrochloride can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis .
Cat. No.: HY-12388S
Synonyms: Desmethylclomipramine-d7; Norclomipramine-d7
Target:
Isotope-Labeled Compounds Drug Metabolite Atg8/LC3 p62 Atg7 MDM-2/p53 PAK Caspase PARP TNF Receptor Parasite Bacterial Autophagy Apoptosis
Domaines de recherche:
N-Desmethyl clomipramine-d7 (Desmethylclomipramine-d7; Norclomipramine-d7) is the deuterated-labeled N-Desmethyl clomipramine (HY-12388). N-Desmethyl clomipramine is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis .
Cat. No.: HY-12388S1
Synonyms: Desmethylclomipramine-d6; Norclomipramine-d6
Target:
Isotope-Labeled Compounds Drug Metabolite Atg8/LC3 p62 Atg7 MDM-2/p53 PAK Caspase PARP TNF Receptor Parasite Bacterial Autophagy Apoptosis
Domaines de recherche:
N-Desmethyl clomipramine-d6 (Desmethylclomipramine-d6; Norclomipramine-d6) is the deuterated-labeled N-Desmethyl clomipramine (HY-12388). N-Desmethyl clomipramine (Desmethylclomipramine; Norclomipramine) is the orally active major active metabolite of the tricyclic antidepressant Clomipramine (HY-B0457A), possessing multiple activities including anti-inflammatory, antioxidant, antibacterial, and antiparasitic effects. N-Desmethyl clomipramine blocks autophagosome-lysosome fusion, leading to the accumulation of LC3-II, p62, ATG7, WIPI2, and ATG5-12, reactivates the p53/p21 pathway, induces apoptosis through C-PARP and C-CAS3, and inhibits the proliferation, migration, and invasion of renal cancer cells. N-Desmethyl clomipramine inhibits LdTOPIA, inducing R-loop accumulation in the nucleus of Leishmania, ultimately causing parasite death. N-Desmethyl clomipramine can be used for research on depression, metastatic renal cell carcinoma, and leishmaniasis .
Cat. No.: HY-187472
Domaines de recherche:
SMA-245 is an inhibitor of Filovirus glycoproteins, acting on Ebola virus (EBOV) and Marburg virus (MARV). SMA-245 blocks the endosomal membrane fusion step of filoviruses by binding to the EBOV GP1/GP2 fusion loop. SMA-245 inhibits MARV viral entry. SMA-245 can be used in research related to filovirus infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
