Search Result
Results for "
heterobifunctional
" in MedChemExpress (MCE) Product Catalog:
87
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-D0975
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ADC Linker
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Cancer
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Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
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- HY-158101
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CC-94676
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PROTACs
Androgen Receptor
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Cancer
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BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader (DC50 of 10-40 nM). BMS-986365 is capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows no degradation of the close AR family members estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. BMS-986365 can be used for the study of metastatic castration-resistant prostate cancer (mCRPC) .
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- HY-78961
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EMCS
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ADC Linker
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Cancer
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates .
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- HY-138539
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- HY-134582
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dCBP-1
Maximum Cited Publications
11 Publications Verification
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PROTACs
Epigenetic Reader Domain
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Cancer
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dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand. dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression .
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- HY-128925
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AMAS
1 Publications Verification
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ADC Linker
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Cancer
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AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.
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- HY-147098
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dTAG-47
1 Publications Verification
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PROTACs
FKBP
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Cancer
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dTAG-47 is a FKBP12F36V PROTAC degrader. dTAG-47 efficiently degrades FKBP12F36V-MELK(sg3R) in MELK ⁻/⁻ MDA-MB-468-FKBP12F36V-MELK(sg3R) cells. dTAG-47 can be used for the research of basal-like breast cancers (BBC). (Pink: FKBP12F36V ligand (HY-114420), Blue: CRBN Ligand (HY-W087383), Black: Linker (HY-42773), E3 ligase ligand-linker conjugate (HY-175952)) .
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- HY-145514A
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PROTACs
FKBP
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Cancer
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dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12 F36V-selective degrader .
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- HY-161157
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PROTACs
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Cancer
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dTAG-13-NEG is a negative control of dTAG-13 (HY-114421). dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest .
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- HY-114421
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dTAG-13
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PROTACs
FKBP
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Cancer
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FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12 F36V and CRBN, thereby selectively degrading FKBP12 F36V .
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- HY-174892
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Biochemical Assay Reagents
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Others
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Biotin-PEG5-NHS ester is a heterobifunctional crosslinker as well as a polyethylene glycol-containing bioconjugation reagent. Biotin-PEG5-NHS ester is widely used in scientific research fields such as the construction of highly sensitive biosensors, the development of targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification, and serves as an important tool for achieving precise labeling and functionalization of biomolecules .
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- HY-145232
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OGTAC-3
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PhosTACs
Phosphatase
Tau Protein
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Neurological Disease
Cancer
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PhosTAC7 is a heterobifunctional molecule named as a Phosphorylation Targeting Chimera (PhosTAC). PhosTAC7 can dephosphorylate the PDCD4 protein, FOXO3a protein, and tau protein by recruiting serine/threonine protein phosphatase 2A (PP2A). PhosTAC7 offers the advantage of selectively modulating the phosphorylation state of individual target proteins, making it a promising tool for research in cancer and tau protein-related neurodegenerative diseases (Alzheimer's disease) .
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- HY-W041994
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- HY-155788
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Biochemical Assay Reagents
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Others
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DSPE-PEG-DBCO ammonium is the ammonium salt form of DSPE-PEG-DBCO. DSPE-PEG-DBCO ammonium is utilized in copper-free click chemistry through SPAAC conjugation with an azido-functionalized peptide ligand. DSPE-PEG-DBCO ammonium is applied in drug-delivery and nanoparticle research .
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- HY-W190796A
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PROTAC Linkers
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Others
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Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 TFA is a crosslinking reagent with a PEG spacer .
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- HY-168664
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PROTACs
CDK
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Cancer
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CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667)) .
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- HY-126502
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ADC Linker
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Others
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Mal-C2-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
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- HY-W190796
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PROTAC Linkers
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Others
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Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a crosslinking reagent with a PEG spacer .
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- HY-134591
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- HY-147099
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PROTACs
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Cancer
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dTAG-47-NEG is an analog of dTAG-47 that cannot bind and recruit cereblon (CRBN). dTAG-47-NEG can be used as a heterobifunctional negative control of dTAG-47 .
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- HY-134592
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- HY-W012166
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NHS-Bromoacetate
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Biochemical Assay Reagents
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Infection
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N-Succinimidyl bromoacetate (NHS-Bromoacetate) is a heterobifunctional crosslinking reagent, mainly used to modify the ɛ-amino group of lysine side chains. By covalently linking its bromoacetyl moiety to the ɛ-amino group of lysine in peptidomimetics, N-Succinimidyl bromoacetate enables their conjugation with thiol-modified nanoparticles via thioether bonds. N-Succinimidyl bromoacetate also performs bromoacetylation modification on carrier proteins, which then forms stable thioether bonds with the thiol groups of cysteine in peptides, thus efficiently preparing soluble peptide-protein conjugates with high substitution ratios. N-Succinimidyl bromoacetate can be used to prepare activated Sepharose derivatives for affinity chromatography, protein affinity labeling reagents, and peptide-protein immunogen conjugates with non-immunogenic linkages. N-Succinimidyl bromoacetate is applicable to studies related to HIV-1 infection and glioblastoma multiforme .
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- HY-140339
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Biochemical Assay Reagents
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Others
Cancer
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ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .
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- HY-W1049061
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG2000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG2000-COOH is an important cross-linker with PEG chains .
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- HY-W1048553A
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Biochemical Assay Reagents
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Others
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Mal-PEG2000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-W588706
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Biochemical Assay Reagents
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Others
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Tetrazine-PEG5-SS-NHS ester is a heterobifunctional crosslinking agent, a PEG derivative composed of NHS ester. NHS ester can bind to amino acids or other amino-containing molecules. Tetrazine-PEG5-SS-NHS ester is used in bioconjugation, bioorthogonal chemistry, and delivery.
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- HY-140232B
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG2000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG2000-NH2 is an important cross-linker with PEG chains .
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- HY-129377
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ADC Linker
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Cancer
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Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
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- HY-126495
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ADC Linker
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Cancer
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Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
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- HY-W1048553B
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Biochemical Assay Reagents
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Others
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Mal-PEG3400-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-W1048553C
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Biochemical Assay Reagents
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Others
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Mal-PEG5000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-176206H
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Biochemical Assay Reagents
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Others
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Biotin-PEG40000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG40000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176509C
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Liposome
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Others
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DSPE-PEG5000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG5000-CHO can be used for drug delivery .
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- HY-176509
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Liposome
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Others
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DSPE-PEG1000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG1000-CHO can be used for drug delivery .
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- HY-145514B
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PROTACs
FKBP
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Cancer
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dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12 F36V-selective degrader .
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- HY-129655
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ADC Linker
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Cancer
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Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
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- HY-161095
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DNA/RNA Synthesis
Integrin
Topoisomerase
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Cancer
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iRGD-CPT is a conjugate of iRGD and camptothecin
that is covalently coupled through a heterobifunctional linker. iRGD-CPT has
anticancer activity in vitroandin vivo.
iRGD-CPT can be used for the study of colon cancer .
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- HY-W1048553
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Biochemical Assay Reagents
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Others
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Mal-PEG1000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-140232D
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG5000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG5000-NH2 is an important cross-linker with PEG chains .
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- HY-178964
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PROTACs
RET
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Cancer
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PROTAC RET Degrader 1 (Compound 20) is an orally active and blood-brain barrier-crossing RET PROTAC degrader with DC50 values for RET (WT), RET (G810S), RET (G810C), and RET (G810R) of 1.7, 3, 12, and 21 nM, respectively. PROTAC RET Degrader 1 exhibits potent anti-proliferative activity in cancer cell lines carrying oncogenic RET fusions (such as KIF5B-RET, CCDC6-RET) or mutations (such as RET (C634W)). PROTAC RET Degrader 1 shows significant anti-tumor activity in human tumor xenograft (PDX) mouse models. PROTAC RET Degrader 1 can be used for the study of RET-positive cancers Pink: RET ligand (HY-179308); Blue: CRBN ligand (HY-179307); Black: Linker) .
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- HY-W1048555B
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Biochemical Assay Reagents
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Others
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Mal-PEG3400-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG3400-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-129377A
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ADC Linker
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Cancer
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Sulfo-SPP sodium a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
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- HY-W1049071D
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Biochemical Assay Reagents
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Others
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HO-PEG40000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-137251
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Biochemical Assay Reagents
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Others
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Sulfo-MBS sodium is a heterobifunctional crosslinker with a maleimide group and an N-hydroxysuccinimide (NHS) ester group, which can react with cysteine residues and lysine residues on proteins. Sulfo-MBS sodium be used for protein cross-linking studies .
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- HY-W190786
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Biochemical Assay Reagents
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Others
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Bromoacetamido-PEG2-azide is a heterobifunctional PEG linker containing a reactive bromoacetamido and a terminal azide.The bromoacetamidogroup is a very reactive group for nucleophilic substitution. The azide group can react with alkyne, BCN, DBCO via Click Chemistry.
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- HY-174364E
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Biochemical Assay Reagents
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Others
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Alkyne-PEG20000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364C
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Biochemical Assay Reagents
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Others
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Alkyne-PEG5000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-W1049061E
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG1000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG1000-COOH is an important cross-linker with PEG chains .
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- HY-W1049061D
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG40000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG40000-COOH is an important cross-linker with PEG chains .
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- HY-W1049061A
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG5000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG5000-COOH is an important cross-linker with PEG chains .
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- HY-W1049061H
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG3400-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG3400-COOH is an important cross-linker with PEG chains .
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- HY-W1048553H
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Biochemical Assay Reagents
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Others
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Mal-PEG40000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-W1048553E
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Biochemical Assay Reagents
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Others
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Mal-PEG20000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-W1048553D
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Biochemical Assay Reagents
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Others
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Mal-PEG10000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
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- HY-156301
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Biochemical Assay Reagents
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Others
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Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.
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- HY-140232C
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG3400-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG3400-NH2 is an important cross-linker with PEG chains .
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- HY-161157A
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PROTACs
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Cancer
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dTAG-13-NEG TFA is a negative control of dTAG-13 (HY-114421). dTAG-13, a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12 F36V with expression of FKBP12F36V in-frame with a protein of interest .
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- HY-W1048542A
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG2000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG2000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542D
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG5000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG5000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542C
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG3400-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG3400-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542H
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG20000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG20000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542I
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG40000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG40000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-W1048542E
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Biochemical Assay Reagents
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Others
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Fmoc-NH-PEG10000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG10000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
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- HY-140232A
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Boc-NH-PEG1000-Amine
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG1000-NH2 (Boc-NH-PEG1000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG1000-NH2 is an important cross-linker with PEG chains .
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- HY-140232H
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Boc-NH-PEG20000-Amine
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG20000-NH2 (Boc-NH-PEG20000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG20000-NH2 is an important cross-linker with PEG chains .
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- HY-140232E
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Boc-NH-PEG10000-Amine
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG10000-NH2 (Boc-NH-PEG10000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG10000-NH2 is an important cross-linker with PEG chains .
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- HY-176206A
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Biochemical Assay Reagents
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Others
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Biotin-PEG2000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG2000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206D
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Biochemical Assay Reagents
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Others
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Biotin-PEG10000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG10000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-140232I
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Boc-NH-PEG40000-Amine
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Biochemical Assay Reagents
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Others
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BOC-NH-PEG40000-NH2 (Boc-NH-PEG40000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG40000-NH2 is an important cross-linker with PEG chains .
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- HY-W1048555D
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Biochemical Assay Reagents
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Others
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Mal-PEG10000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG10000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048572A
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PROTAC Linkers
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Others
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N3-PEG2000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG2000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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-
- HY-W1048555
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Biochemical Assay Reagents
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Others
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|
Mal-PEG1000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG1000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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-
- HY-W440954
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Liposome
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Others
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|
Stearic acid-PEG2000-CH2CO2H is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
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-
- HY-176509D
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Liposome
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Others
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|
DSPE-PEG10000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG10000-CHO can be used for drug delivery .
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-
- HY-176509B
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Liposome
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Others
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|
DSPE-PEG3400-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG3400-CHO can be used for drug delivery .
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-
- HY-D3279
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Biochemical Assay Reagents
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Others
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SMCC-PE is a dipalmitoylphosphatidylethanolamine derivative modified with the heterobifunctional crosslinker SMCC. SMCC-PE is an intermediate formed by conjugating the SMCC linker with R-phycoerythrin for antibody conjugation .
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- HY-W1049071C
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Biochemical Assay Reagents
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Others
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HO-PEG20000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071A
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Biochemical Assay Reagents
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Others
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HO-PEG5000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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-
- HY-W1049071I
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Biochemical Assay Reagents
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Others
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HO-PEG3400-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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-
- HY-W1049071B
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Biochemical Assay Reagents
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Others
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|
HO-PEG10000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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-
- HY-W1049071H
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Biochemical Assay Reagents
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Others
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|
HO-PEG2000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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-
- HY-W1049071E
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Biochemical Assay Reagents
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Others
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|
HO-PEG1000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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-
- HY-W615173
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Biochemical Assay Reagents
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Others
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|
NHS ester-C2-NHCO-C2-NHS is a heterobifunctional PEG linker, featuring a terminal NHS ester that can be used to label amine compounds and maleimide group for reactions with thiol groups.
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-
- HY-174364B
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Biochemical Assay Reagents
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Others
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Alkyne-PEG3400-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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-
- HY-172719
-
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Biochemical Assay Reagents
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Others
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|
Fmoc-PEG9-alcohol is a heterobifunctional PEG linker featuring a Fmoc-protected primary amine and an alcohol group. The hydroxy group is a versatile functionality while the Fmoc protecting group can be removed with base to reveal a primary amine.
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-
- HY-174364
-
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Biochemical Assay Reagents
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Others
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|
Alkyne-PEG1000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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-
- HY-174364H
-
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Biochemical Assay Reagents
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Others
|
|
Alkyne-PEG40000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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-
- HY-174364D
-
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Biochemical Assay Reagents
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Others
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|
Alkyne-PEG10000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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-
- HY-174364A
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Biochemical Assay Reagents
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Others
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|
Alkyne-PEG2000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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-
- HY-W1049061B
-
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Biochemical Assay Reagents
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Others
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|
Boc-NH-PEG10000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG10000-COOH is an important cross-linker with PEG chains .
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-
- HY-W1049061C
-
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Biochemical Assay Reagents
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Others
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Boc-NH-PEG20000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG20000-COOH is an important cross-linker with PEG chains .
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-
- HY-W190925
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Biochemical Assay Reagents
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Others
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APN-C3-biotin is a heterobifunctional linker containing an APN moiety with exquisite chemoselectivity for cysteine and Biotin. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
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-
- HY-176206
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Biochemical Assay Reagents
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Others
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Biotin-PEG1000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG1000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206B
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Biochemical Assay Reagents
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Others
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Biotin-PEG3400-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG3400-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206C
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Biochemical Assay Reagents
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Others
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Biotin-PEG5000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG5000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206E
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Biochemical Assay Reagents
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Others
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Biotin-PEG20000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG20000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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-
- HY-W1048555H
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Biochemical Assay Reagents
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Others
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Mal-PEG40000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG40000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048572E
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PROTAC Linkers
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Others
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|
N3-PEG5000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG5000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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-
- HY-W1048555C
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Biochemical Assay Reagents
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Others
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|
Mal-PEG5000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG5000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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-
- HY-W1048555E
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Biochemical Assay Reagents
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Others
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|
Mal-PEG20000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG20000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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-
- HY-176509E
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Liposome
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Others
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|
DSPE-PEG20000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG20000-CHO can be used for drug delivery .
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-
- HY-176509H
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Liposome
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Others
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|
DSPE-PEG40000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG40000-CHO can be used for drug delivery .
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-
- HY-176509A
-
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Liposome
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Others
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|
DSPE-PEG2000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG2000-CHO can be used for drug delivery .
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-
- HY-W1048545H
-
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Amine-PEG1000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
|
|
H2N-PEG1000-SH (Amine-PEG1000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG1000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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-
- HY-W1048545I
-
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Amine-PEG3400-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
|
|
H2N-PEG3400-SH (Amine-PEG3400-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG3400-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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-
- HY-W1048545E
-
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Amine-PEG20000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
|
|
H2N-PEG20000-SH (Amine-PEG20000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG20000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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-
- HY-W1048545D
-
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Amine-PEG10000-Thiol hydrochloride
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Biochemical Assay Reagents
|
Others
|
|
H2N-PEG10000-SH (Amine-PEG10000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG10000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-182577
-
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|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
CFT-743, a PROTAC-based heterobifunctional degrader and BET inhibtor, is a degrader of BRD4 bromodomain 1 (BD1) with a DC50 of 4.3 nM. CFT-743's antitumor activitiy is dependent on BET degradation and can be attenuated by Pomalidomide (HY-10984), which is a CRBN binding molecule. CFT-743 induces ubiquitination of BRD4 BD1. CFT-743 can be used for cancer research .
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-
- HY-W1048572I
-
|
Azide-PEG20000-Amine
|
PROTAC Linkers
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Others
|
|
N3-PEG20000-NH2 (Azide-PEG20000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG20000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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-
- HY-W1048545A
-
|
Amine-PEG2000-Thiol hydrochloride
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Biochemical Assay Reagents
|
Others
|
|
H2N-PEG2000-SH (Amine-PEG2000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG2000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-122653
-
|
|
PROTACs
|
Cancer
|
|
CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
|
-
- HY-138642
-
|
ARV-471
|
PROTACs
Estrogen Receptor/ERR
|
Cancer
|
|
Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
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-
- HY-W1048545J
-
|
Amine-PEG40000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG40000-SH (Amine-PEG40000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG40000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048572C
-
|
Azide-PEG1000-Amine
|
Biochemical Assay Reagents
|
Others
|
|
N3-PEG1000-NH2 (Azide-PEG1000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG1000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-182801
-
|
|
PROTACs
Epigenetic Reader Domain
c-Myc
|
Cancer
|
|
PROTAC BRD4 Degrader-46 is a heterobifunctional BRD4 PROTAC degrader. PROTAC BRD4 Degrader-46 binds to both BRD4 and CRBN, thereby triggering ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-46 downregulates the levels of downstream BRD2, BRD3 and MYC. PROTAC BRD4 Degrader-46 can be used in the research of cancers such as multiple myeloma .
|
-
- HY-W1048572H
-
|
Azide-PEG10000-Amine
|
PROTAC Linkers
|
Others
|
|
N3-PEG10000-NH2 (Azide-PEG10000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG10000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572D
-
|
Azide-PEG3400-Amine
|
PROTAC Linkers
|
Others
|
|
N3-PEG3400-NH2 (Azide-PEG3400-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG3400-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048572J
-
|
Azide-PEG40000-Amine
|
PROTAC Linkers
|
Others
|
|
N3-PEG40000-NH2 (Azide-PEG40000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG40000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048545C
-
|
Amine-PEG5000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
Others
|
|
H2N-PEG5000-SH (Amine-PEG5000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG5000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-138642A
-
|
(Rac)-ARV-471
|
Estrogen Receptor/ERR
PROTACs
|
Cancer
|
|
(Rac)-Vepdegestrant is the isomer of Vepdegestrant (HY-138642). Vepdegestrant ((R)-Lavandulol) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of about 2 nM .
|
-
- HY-W1048547A
-
|
HOOC-PEG2000-Amine
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG2000-NH2 (HOOC-PEG2000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547H
-
|
HOOC-PEG1000-Amine
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG1000-NH2 (HOOC-PEG1000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547E
-
|
HOOC-PEG20000-Amine
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG20000-NH2 (HOOC-PEG20000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547I
-
|
HOOC-PEG3400-Amine
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG3400-NH2 (HOOC-PEG3400-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547J
-
|
HOOC-PEG40000-Amine
|
PROTAC Linkers
|
Others
|
|
HOOC-PEG40000-NH2 (HOOC-PEG40000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1048547C
-
|
HOOC-PEG5000-Amine
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG5000-NH2 (HOOC-PEG5000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1005067
-
|
|
Molecular Glues
Hippo (MST)
Estrogen Receptor/ERR
|
Others
|
|
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .
|
-
- HY-180188
-
|
|
Autophagy
|
Cardiovascular Disease
Cancer
|
|
F1-ispinesib is a heterobifunctional F1-autophagy degrader, composed of an RNA-binding fragment (F1) and the LC3B ligand Ispinesib (HY-50759). F1-ispinesib induces degradation of COL15A1 mRNA via an LC3B-dependent macroautophagy mechanism. F1-ispinesib inhibits cell proliferation and enhances migration of human aortic smooth muscle cells .
|
-
- HY-W1048547D
-
|
HOOC-PEG10000-Amine
|
Biochemical Assay Reagents
|
Others
|
|
HOOC-PEG10000-NH2 (HOOC-PEG10000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-122653A
-
|
|
PROTACs
|
Cancer
|
|
CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
|
-
- HY-134850
-
|
|
PROTACs
Tau Protein
|
Neurological Disease
|
|
QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)) .
|
-
- HY-138642S
-
|
ARV-471-d5
|
Isotope-Labeled Compounds
|
Cancer
|
|
Vepdegestrant-d5 (ARV-471-d5) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC50 of about 2 nM .
|
-
- HY-123941
-
|
dTAG-7
|
PROTACs
FKBP
Epigenetic Reader Domain
|
Others
|
|
FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional PROTAC degrader. FKBP12 PROTAC dTAG-7 targets FKBP12 F36V and BET BRD4. FKBP12 PROTAC dTAG-7 enables rapid and selective degradation of target proteins, and is suitable for cellular and in vivo studies to analyze protein functions and validate targets . (Pink: target protein ligand (HY-114420); Black: linker (HY-128844); Blue: CRBN Ligand (HY-103597); CRBN Ligand+linker: (HY-W722323))
|
-
- HY-W1048555A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Mal-PEG2000-SCM is a heterobifunctional PEG crosslinker bearing maleimide and succinimidyl carboxymethyl ester functional groups. MMal-PEG2000-SCM conjugates the F3 peptide to nanoparticles: the SCM group reacts with amino groups on the nanoparticle surface to form amide groups, while the MAL group reacts with thiol groups of the F3 peptide to form carbon-sulfur bonds. Mal-PEG-SCM enables unidirectional addition of linkers, ensuring that appropriate functional groups are available for RGD incorporation. Mal-PEG2000-SCM can be used in the development of nanoparticles targeting specific tumor cells .
|
-
- HY-176501
-
|
|
FKBP
|
Cancer
|
|
FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .
|
-
- HY-161769
-
|
|
PROTACs
Epigenetic Reader Domain
Apoptosis
|
Cancer
|
|
HL435 is a heterobifunctional molecule that degrades BRD4 by linking to JQ1, with DC50 of 11.9 nM and 21.9 nM, in MDA-MB-231 and MCF-7 cells, respectively. HL435 inhibits the proliferation of MDA-MB-231, MCF-7, 22Rv1 and A549, arrests the cell cycle and induces apoptosis. HL435 exhibits antitumor activity in mouse model. (Pink: ligand for target protein JQ-1 (HY-78695); Black: linker (HY-W004640); blue: ligand for E3 ligase HL389 (HY-161770))
|
-
- HY-176502
-
|
|
FKBP
|
Cancer
|
|
FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .
|
-
- HY-145925B
-
CFT8634
1 Publications Verification
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor) .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D3279
-
|
|
Fluorescent Dyes
|
|
SMCC-PE is a dipalmitoylphosphatidylethanolamine derivative modified with the heterobifunctional crosslinker SMCC. SMCC-PE is an intermediate formed by conjugating the SMCC linker with R-phycoerythrin for antibody conjugation .
|
| Cat. No. |
Product Name |
Type |
-
- HY-D0975
-
|
|
Biochemical Assay Reagents
|
|
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
|
-
- HY-174892
-
|
|
Biochemical Assay Reagents
|
|
Biotin-PEG5-NHS ester is a heterobifunctional crosslinker as well as a polyethylene glycol-containing bioconjugation reagent. Biotin-PEG5-NHS ester is widely used in scientific research fields such as the construction of highly sensitive biosensors, the development of targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification, and serves as an important tool for achieving precise labeling and functionalization of biomolecules .
|
-
- HY-77961
-
|
N-ε-Maleimidocaproic acid hydrazide TFA
|
Biochemical Assay Reagents
|
|
6-Maleimidocaproic acid hydrazide TFA is a carbonyl and sulfhydryl reactive heterobifunctional crosslinking reagent .
|
-
- HY-W1048555A
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG2000-SCM is a heterobifunctional PEG crosslinker bearing maleimide and succinimidyl carboxymethyl ester functional groups. MMal-PEG2000-SCM conjugates the F3 peptide to nanoparticles: the SCM group reacts with amino groups on the nanoparticle surface to form amide groups, while the MAL group reacts with thiol groups of the F3 peptide to form carbon-sulfur bonds. Mal-PEG-SCM enables unidirectional addition of linkers, ensuring that appropriate functional groups are available for RGD incorporation. Mal-PEG2000-SCM can be used in the development of nanoparticles targeting specific tumor cells .
|
-
- HY-W1049061
-
|
|
Biochemical Assay Reagents
|
|
Boc-NH-PEG2000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG2000-COOH is an important cross-linker with PEG chains .
|
-
- HY-W1048553A
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG2000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W588706
-
|
|
Biochemical Assay Reagents
|
|
Tetrazine-PEG5-SS-NHS ester is a heterobifunctional crosslinking agent, a PEG derivative composed of NHS ester. NHS ester can bind to amino acids or other amino-containing molecules. Tetrazine-PEG5-SS-NHS ester is used in bioconjugation, bioorthogonal chemistry, and delivery.
|
-
- HY-140232B
-
|
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG2000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG2000-NH2 is an important cross-linker with PEG chains .
|
-
- HY-176509A
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG2000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG2000-CHO can be used for drug delivery .
|
-
- HY-W1048553B
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG3400-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553C
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG5000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-176206H
-
|
|
Biochemical Assay Reagents
|
|
Biotin-PEG40000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG40000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176509C
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG5000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG5000-CHO can be used for drug delivery .
|
-
- HY-176509
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG1000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG1000-CHO can be used for drug delivery .
|
-
- HY-W1048572D
-
|
Azide-PEG3400-Amine
|
Biochemical Assay Reagents
|
|
N3-PEG3400-NH2 (Azide-PEG3400-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG3400-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048553
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG1000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-140232D
-
|
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG5000-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG5000-NH2 is an important cross-linker with PEG chains .
|
-
- HY-W1048555B
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG3400-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG3400-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048545H
-
|
Amine-PEG1000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG1000-SH (Amine-PEG1000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG1000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048572C
-
|
Azide-PEG1000-Amine
|
Biochemical Assay Reagents
|
|
N3-PEG1000-NH2 (Azide-PEG1000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG1000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048547J
-
|
HOOC-PEG40000-Amine
|
Biochemical Assay Reagents
|
|
HOOC-PEG40000-NH2 (HOOC-PEG40000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
|
-
- HY-W1049071D
-
|
|
Biochemical Assay Reagents
|
|
HO-PEG40000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
|
-
- HY-174364E
-
|
|
Biochemical Assay Reagents
|
|
Alkyne-PEG20000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-174364C
-
|
|
Biochemical Assay Reagents
|
|
Alkyne-PEG5000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
|
-
- HY-W1049061E
-
|
|
Biochemical Assay Reagents
|
|
Boc-NH-PEG1000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG1000-COOH is an important cross-linker with PEG chains .
|
-
- HY-W1049061D
-
|
|
Biochemical Assay Reagents
|
|
Boc-NH-PEG40000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG40000-COOH is an important cross-linker with PEG chains .
|
-
- HY-W1049061A
-
|
|
Biochemical Assay Reagents
|
|
Boc-NH-PEG5000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG5000-COOH is an important cross-linker with PEG chains .
|
-
- HY-W1049061H
-
|
|
Biochemical Assay Reagents
|
|
Boc-NH-PEG3400-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG3400-COOH is an important cross-linker with PEG chains .
|
-
- HY-W1048553H
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG40000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553E
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG20000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-W1048553D
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG10000-NH2TFA is a linear heterobifunctional PEG product with maleimide and NH2 groups. The maleimide can react with thiols, SH, sulfhydryls or sulfhydryls, and the amine can react with carboxylic acids or activated NHS esters .
|
-
- HY-140232C
-
|
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG3400-NH2 is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG3400-NH2 is an important cross-linker with PEG chains .
|
-
- HY-W1048542A
-
|
|
Biochemical Assay Reagents
|
|
Fmoc-NH-PEG2000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG2000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542D
-
|
|
Biochemical Assay Reagents
|
|
Fmoc-NH-PEG5000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG5000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542C
-
|
|
Biochemical Assay Reagents
|
|
Fmoc-NH-PEG3400-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG3400-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542H
-
|
|
Biochemical Assay Reagents
|
|
Fmoc-NH-PEG20000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG20000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542I
-
|
|
Biochemical Assay Reagents
|
|
Fmoc-NH-PEG40000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG40000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-W1048542E
-
|
|
Biochemical Assay Reagents
|
|
Fmoc-NH-PEG10000-COOH is a linear hetero-bifunctional PEG product with two Fmoc-protected amines and a carboxylic acid at both ends. Fmoc-NH-PEG10000-COOH is an important cross-linking agent with PEG chains. The protected amine can be regenerated by mild alkaline conditions .
|
-
- HY-140232A
-
|
Boc-NH-PEG1000-Amine
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG1000-NH2 (Boc-NH-PEG1000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG1000-NH2 is an important cross-linker with PEG chains .
|
-
- HY-140232H
-
|
Boc-NH-PEG20000-Amine
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG20000-NH2 (Boc-NH-PEG20000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG20000-NH2 is an important cross-linker with PEG chains .
|
-
- HY-140232E
-
|
Boc-NH-PEG10000-Amine
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG10000-NH2 (Boc-NH-PEG10000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG10000-NH2 is an important cross-linker with PEG chains .
|
-
- HY-176206A
-
|
|
Biochemical Assay Reagents
|
|
Biotin-PEG2000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG2000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-176206D
-
|
|
Biochemical Assay Reagents
|
|
Biotin-PEG10000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG10000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
|
-
- HY-140232I
-
|
Boc-NH-PEG40000-Amine
|
Biochemical Assay Reagents
|
|
BOC-NH-PEG40000-NH2 (Boc-NH-PEG40000-Amine) is a linear hetero-bifunctional PEG product with one Boc-protected amine and one amino group. BOC-NH-PEG40000-NH2 is an important cross-linker with PEG chains .
|
-
- HY-W1048555D
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG10000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG10000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-W1048572A
-
|
|
Biochemical Assay Reagents
|
|
N3-PEG2000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG2000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
-
- HY-W1048555
-
|
|
Biochemical Assay Reagents
|
|
Mal-PEG1000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG1000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
|
-
- HY-176509D
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG10000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG10000-CHO can be used for drug delivery .
|
-
- HY-176509B
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG3400-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG3400-CHO can be used for drug delivery .
|
-
- HY-176509H
-
|
|
Biochemical Assay Reagents
|
|
DSPE-PEG40000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG40000-CHO can be used for drug delivery .
|
- HY-W1048545D
-
|
Amine-PEG10000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG10000-SH (Amine-PEG10000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG10000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
- HY-W1048572I
-
|
Azide-PEG20000-Amine
|
Biochemical Assay Reagents
|
|
N3-PEG20000-NH2 (Azide-PEG20000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG20000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
|
- HY-W1048545A
-
|
Amine-PEG2000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG2000-SH (Amine-PEG2000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG2000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
- HY-W1048572H
-
|
Azide-PEG10000-Amine
|
Biochemical Assay Reagents
|
|
N3-PEG10000-NH2 (Azide-PEG10000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG10000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1049071C
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Biochemical Assay Reagents
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HO-PEG20000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071A
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Biochemical Assay Reagents
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HO-PEG5000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071I
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Biochemical Assay Reagents
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HO-PEG3400-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071B
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Biochemical Assay Reagents
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HO-PEG10000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071H
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Biochemical Assay Reagents
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HO-PEG2000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-W1049071E
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Biochemical Assay Reagents
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HO-PEG1000-SCM is a hetero-bifunctional hydroxy PEG succinimidyl carboxymethyl ester product, which is commonly used as a cross-linker or spacer between two different chemical entities.
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- HY-174364B
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Biochemical Assay Reagents
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Alkyne-PEG3400-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364
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Biochemical Assay Reagents
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Alkyne-PEG1000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364H
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Biochemical Assay Reagents
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Alkyne-PEG40000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364D
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Biochemical Assay Reagents
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Alkyne-PEG10000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-174364A
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Biochemical Assay Reagents
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Alkyne-PEG2000-COOH is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other material surfaces. The carboxyl group can react with the amine group to form a stable amide bond .
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- HY-W1049061B
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Biochemical Assay Reagents
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Boc-NH-PEG10000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG10000-COOH is an important cross-linker with PEG chains .
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- HY-W1049061C
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Biochemical Assay Reagents
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Boc-NH-PEG20000-COOH is a linear hetero-bifunctional PEG product with one Boc-protected amine and one carboxyl group. Boc-NH-PEG20000-COOH is an important cross-linker with PEG chains .
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- HY-176206
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Biochemical Assay Reagents
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Biotin-PEG1000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG1000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206B
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Biochemical Assay Reagents
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Biotin-PEG3400-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG3400-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206C
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Biochemical Assay Reagents
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Biotin-PEG5000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG5000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-176206E
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Biochemical Assay Reagents
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Biotin-PEG20000-COOH is a linear heterobifunctional PEG compound with biotin and carboxylic acid functional groups. Biotin can bind to avidin and streptavidin with high specificity and affinity. Biotin-PEG20000-COOH can be used to biotin-label antibodies, proteins and other macromolecules containing primary amines in the presence of a condensing agent .
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- HY-W1048555H
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Biochemical Assay Reagents
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Mal-PEG40000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG40000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048572E
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Biochemical Assay Reagents
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N3-PEG5000-NH2 is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG5000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048555C
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Biochemical Assay Reagents
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Mal-PEG5000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG5000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-W1048555E
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Biochemical Assay Reagents
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Mal-PEG20000-SCM is a linear hetero-bifunctional PEG product with maleimide and succinimidyl NHS ester groups. Mal-PEG20000-SCM is an important cross-linker with PEG chains. Maleimide reacts with thiols, SH, sulfhydryls or sulfhydryls, and SCM stands for succinimidyl carboxymethyl ester, which reacts with primary amines. Maleimide contains a reactive C=C double bond and is sensitive to light or oxygen .
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- HY-176509E
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Biochemical Assay Reagents
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DSPE-PEG20000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG20000-CHO can be used for drug delivery .
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- HY-W1048545I
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Amine-PEG3400-Thiol hydrochloride
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Biochemical Assay Reagents
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H2N-PEG3400-SH (Amine-PEG3400-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG3400-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545E
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Amine-PEG20000-Thiol hydrochloride
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Biochemical Assay Reagents
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H2N-PEG20000-SH (Amine-PEG20000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG20000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545J
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Amine-PEG40000-Thiol hydrochloride
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Biochemical Assay Reagents
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H2N-PEG40000-SH (Amine-PEG40000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG40000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048572J
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Azide-PEG40000-Amine
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Biochemical Assay Reagents
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N3-PEG40000-NH2 (Azide-PEG40000-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG40000-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester .
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- HY-W1048545C
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Amine-PEG5000-Thiol hydrochloride
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Biochemical Assay Reagents
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H2N-PEG5000-SH (Amine-PEG5000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG5000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048547A
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HOOC-PEG2000-Amine
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Biochemical Assay Reagents
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HOOC-PEG2000-NH2 (HOOC-PEG2000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547H
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HOOC-PEG1000-Amine
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Biochemical Assay Reagents
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HOOC-PEG1000-NH2 (HOOC-PEG1000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547E
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HOOC-PEG20000-Amine
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Biochemical Assay Reagents
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HOOC-PEG20000-NH2 (HOOC-PEG20000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547I
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HOOC-PEG3400-Amine
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Biochemical Assay Reagents
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HOOC-PEG3400-NH2 (HOOC-PEG3400-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547C
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HOOC-PEG5000-Amine
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Biochemical Assay Reagents
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HOOC-PEG5000-NH2 (HOOC-PEG5000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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- HY-W1048547D
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HOOC-PEG10000-Amine
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Biochemical Assay Reagents
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HOOC-PEG10000-NH2 (HOOC-PEG10000-Amine) is a heterobifunctional PEG crosslinker that can be used to attach functional PEG to biomolecules, particles, and other surface materials. The carboxyl group reacts with the amine group to form a stable amide bond. It can also react with the hydroxyl group to form an unstable ester bond. On the other hand, the amine group can be used to react with many amine-reactive groups, such as succinimidyl NHS esters, aldehydes, etc .
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| Cat. No. |
Product Name |
Chemical Structure |
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- HY-138642S
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Vepdegestrant-d5 (ARV-471-d5) is the deuterium labeled Vepdegestrant (HY-138642). Vepdegestrant (ARV-471) is an orally active PROTAC estrogen receptor degrader against breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a DC50 of about 2 nM .
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| Cat. No. |
Product Name |
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Classification |
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- HY-155788
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DBCO
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DSPE-PEG-DBCO ammonium is the ammonium salt form of DSPE-PEG-DBCO. DSPE-PEG-DBCO ammonium is utilized in copper-free click chemistry through SPAAC conjugation with an azido-functionalized peptide ligand. DSPE-PEG-DBCO ammonium is applied in drug-delivery and nanoparticle research .
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- HY-140339
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PROTAC Synthesis
Azide
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ANB-NOS is a heterobifunctional crosslinker with lipophilic, uncharged properties suitable for intracellular conjugation. ANB-NOS contains an amine-reactive Nhydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. ANB-NOS can be used for the research of fibrosarcoma and mammary adenocarcinoma .
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- HY-176502
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Alkynes
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FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .
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- HY-176501
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Alkynes
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FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .
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- HY-156301
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Tetrazine
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Methyltetrazine-amido-PEG8-amine Trifluoroacetate is a heterobifunctional linker containing a terminal methyltetrazine, which can react with TCO-containing compounds without the catalysis of Cu or elevated temperatures, and terminal amine, which reacts with NHS ester specifically and efficiently. The PEG spacer enhances water solubility.
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| Cat. No. |
Product Name |
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Classification |
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- HY-176509A
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Pegylated Lipids
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DSPE-PEG2000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG2000-CHO can be used for drug delivery .
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- HY-176509C
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Pegylated Lipids
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DSPE-PEG5000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG5000-CHO can be used for drug delivery .
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- HY-176509
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Pegylated Lipids
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DSPE-PEG1000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG1000-CHO can be used for drug delivery .
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- HY-W440954
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Pegylated Lipids
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Stearic acid-PEG2000-CH2CO2H is a heterobifunctional polyPEG with 18-carbon aliphatic chain and carboxyl. The polymer has stearic acid as the hydrophobic tail and PEG as the hydrophilic chain, therefore it forms micelles in water. Carboxyl can react with amine in the presence of activator, such as HATU/EDC to generate a stable amide bond. Reagent grade, for research use only.
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- HY-176509D
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Pegylated Lipids
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DSPE-PEG10000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG10000-CHO can be used for drug delivery .
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- HY-176509B
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Pegylated Lipids
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DSPE-PEG3400-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG3400-CHO can be used for drug delivery .
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- HY-176509H
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Pegylated Lipids
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DSPE-PEG40000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG40000-CHO can be used for drug delivery .
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- HY-176509E
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Pegylated Lipids
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DSPE-PEG20000-CHO is a linear heterobifunctional PEGylation reagent with DSPE phospholipids and aldehyde groups. PEG linkers have good hydrophilicity and water solubility. Aldehyde-polyethylene glycol (DSPE) is one of the most commonly used reactive phospholipids to bind antibodies, peptides or other ligands to the surface of liposomes and other lipid-polyethylene glycol nanoparticles. DSPE-PEG20000-CHO can be used for drug delivery .
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