Search Result

Results for "

hexokinase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Hexokinase (24) AMPK (1) Antibiotic (1) Apoptosis (11) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Drug Derivative (1) Glucose-6-Phosphate Isomerase (GPI) (2) GLUT (1) HSV (5) Isotope-Labeled Compounds (6) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Mitophagy (1) Parasite (3) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) VDAC (1)
By Research Areas:	Cancer (19) Infection (2) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Hexokinase Glucokinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13966

2-Deoxy-D-glucose 345+ Cited Publications 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Hexokinase HSV Apoptosis	Cancer
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-19992

3-Bromopyruvic acid 30+ Cited Publications Bromopyruvic acid; 3-BrPA; hexokinase II inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-B0486

Lonidamine 15+ Cited Publications AF-1890; Diclondazolic Acid; DICA	Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Metabolic Disease Inflammation/Immunology Cancer
Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-134929

Benitrobenrazide 2 Publications Verification BNBZ; hexokinase 2 inhibitor 1	Hexokinase Apoptosis	Cancer
Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC₅₀ of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect .

HY-155008

PROTAC HK2 Degrader-1 2 Publications Verification	PROTACs Hexokinase	Cancer
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research .

HY-U00462

D-Mannoheptulose	Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-175035

HK-2-IN-1	Hexokinase	Inflammation/Immunology Cancer
HK-2-IN-1 is a Hexokinase 2 (HK-2) inhibitor. HK-2-IN-1 exhibits a non-activating effect on human recombinant HK-2 enzyme. HK-2-IN-1 has anti-tumor activity, affecting immune cells in the tumor microenvironment. HK-2-IN-1 has immunomodulatory effects and is potentially useful in the study of cancers such as colon cancer, liver cancer, and breast cancer .

HY-139409A

2-Deoxy-D-glucose 6-phosphate disodium 2 Publications Verification	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive *Hexokinase* inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

HY-13966S

2-Deoxy-D-glucose-d1 1 Publications Verification 2-DG-d₁; 2-Deoxy-D-arabino-hexose-d₁; D-Arabino-2-deoxyhexose-d₁	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-B0486R

Lonidamine (Standard) AF-1890 (Standard); Diclondazolic Acid (Standard); DICA (Standard)	Reference Standards Hexokinase Mitochondrial Metabolism Apoptosis Parasite	Inflammation/Immunology Cancer
Lonidamine (Standard) is the analytical standard of Lonidamine. This product is intended for research and analytical applications. Lonidamine (AF-1890) is a *hexokinase* and mitochondrial pyruvate carrier inhibitor (K_i: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis .

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

HY-W000133

Metrizamide Amipaque	Hexokinase	Neurological Disease
Metrizamide (Amipaque) is used as the contrast medium for angiography in neuroradiological investigations . Metrizamide inhibits human brain hexokinase .

HY-111331

Germicidin B	Antibiotic Hexokinase Bacterial	Infection
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits *hexokinase* II with an IC₅₀ of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections .

HY-13966S2

2-Deoxy-D-glucose-13C 2-DG-¹³C; 2-Deoxy-D-arabino-hexose-¹³C; D-Arabino-2-deoxyhexose-¹³C	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-169728

SID 24785302	Hexokinase Parasite	Infection
SID 24785302 is a *hexokinase* inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection .

HY-168717

HK-2-IN-2	Hexokinase Microtubule/Tubulin Reactive Oxygen Species (ROS)	Cancer
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC₅₀ value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle .

HY-139409

2-Deoxy-D-glucose 6-phosphate	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive *Hexokinase* inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research .

HY-13966S4

2-Deoxy-D-glucose-13C-1 2-DG-¹³C-1; 2-Deoxy-D-arabino-hexose-¹³C-1; D-Arabino-2-deoxyhexose-¹³C-1	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S3

2-Deoxy-D-glucose-13C6 2-DG-¹³C₆; 2-Deoxy-D-arabino-hexose-¹³C₆; D-Arabino-2-deoxyhexose-¹³C₆	Isotope-Labeled Compounds Apoptosis Hexokinase HSV	Cancer
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-W767186

D-Mannoheptulose-13C7	Isotope-Labeled Compounds Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-U00462S

D-Mannoheptulose-13C	Isotope-Labeled Compounds Hexokinase	Metabolic Disease Cancer
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-139409B

2-Deoxy-D-glucose 6-phosphate sodium	Drug Derivative	Metabolic Disease
2-Deoxy-D-glucose 6-phosphate sodium, a derivative of 2-Deoxy-D-glucose (HY-13966), is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-183809

ZSW	Hexokinase	Inflammation/Immunology
ZSW is a hexokinase 2 (HK2) inhibitor with human HK2 IC₅₀ of 0.48 μM, human HK2 K_a of 252.00 μM, and selectivity over HK3 and GCK. ZSW binds directly to HK2, inhibits its enzymatic activity, modulates macrophage phenotypes through glycolysis inhibition, and inhibits NF-κB nuclear translocation by preventing IκBα phosphorylation and degradation. ZSW alleviates inflammatory bowel disease (IBD) and improves the intestinal inflammatory state of IBD mice. ZSW can be used for the research of inflammatory bowel disease .

HY-180805

HK2-IN-3	Hexokinase Mitophagy Apoptosis GLUT	Cancer
HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC₅₀ of 56.4 nM. HK2-IN-3 reduces glucose uptake and downregulated GLUT1/GLUT4 in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy and apoptosis. HK2-IN-3 suppresses tumor growth and angiogenesis in OSCC xenograft mouse models. HK2-IN-3 can be used for OSCC research .

HY-182243

HK2-IN-4	Hexokinase VDAC Apoptosis AMPK Bcl-2 Family	Cancer
HK2-IN-4 is a selective hexokinase 2 (HK2) inhibitor with an IC₅₀ value of 0.79 μM and a K_d value of 0.41 μM. HK2-IN-4 blocks the interaction between HK2 and voltage-dependent anion channel 1 (VDAC1). HK2-IN-4 reduces lactate and ATP levels in cancer cells. HK2-IN-4 induces the production of apoptosis (apoptosis) markers in cancer cells, including increased p-AMPK/AMPK ratio and Bax levels, as well as decreased Bcl2 levels. HK2-IN-4 inhibits the proliferation of cancer cells with high HK2 expression. HK2-IN-4 can be used in research related to colorectal cancer and non-small cell lung cancer .

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library	1,296 compounds
Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation. Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications. MCE provides a unique collection of 1,296 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

Glycolysis Compound Library

1,296 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,296 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L009

Kinase Inhibitor Library	3,886 compounds
Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. Kinase inhibitor library designed by MCE contains 3,886 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Kinase Inhibitor Library

3,886 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,886 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13966

2-Deoxy-D-glucose 345+ Cited Publications 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Source Classification Cancer	Hexokinase HSV Apoptosis
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-U00462

D-Mannoheptulose	Persea americana Mill Classification of Application Fields Metabolic Disease Plants Lauraceae Disease Research Fields Saccharides Monosaccharides Source Classification	Hexokinase
D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-111331

Germicidin B	Structural Classification Microorganisms Antibiotics Source Classification	Antibiotic Hexokinase Bacterial
Germicidin B is an antibiotic with bactericidal activity. Germicidin B inhibits *hexokinase* II with an IC₅₀ of 25.16 μM. Germicidin B suppresses spore germination in Streptomyces. Germicidin B is applicable to studies on bacterial infections .

Cat. No.	Product Name	Chemical Structure

HY-13966S

2-Deoxy-D-glucose-d1 1 Publications Verification
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S2

2-Deoxy-D-glucose-13C
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S4

2-Deoxy-D-glucose-13C-1
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S3

2-Deoxy-D-glucose-13C6
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-W767186

D-Mannoheptulose-13C7
D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

D-Mannoheptulose-13C7

D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

HY-U00462S

D-Mannoheptulose-13C
D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by *hexokinase* isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

D-Mannoheptulose-13C

D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) . D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks