15 Results for "

human FcRn

" in MedChemExpress (MCE) Product Catalog:
Products (15)

15 Results for "human FcRn" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P9979
CAS No.: 1584645-37-3
Synonyms: UCB7665

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Rozanolixizumab (UCB7665), a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P), is used to the research of reducing pathogenic IgG in autoimmune and alloimmune diseases .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P70601
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IgG receptor FcRn; Neonatal Fc receptor; FcRn
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P99965
CAS No.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
loading...
    loading...
Cat. No.: HY-P990937
CAS No.: 2948444-06-0
Synonyms: PF-04236921; TOUR-006

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Pacibekitug (PF-04236921; TOUR-006) is a fully humanized IgG2 monoclonal antibody targeting IL-6. Pacibekitug binds to and neutralizes IL-6 signaling, thereby inhibiting the pathophysiological role of this pro-inflammatory cytokine in autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, and systemic lupus erythematosus) [1][2].
loading...
    loading...
Cat. No.: HY-P991476

Target:  

Fc Receptor (FcR)

Research Areas:  

Cancer

MDX-220 is a human monoclonal antibody (mAb) targeting FcRn. MDX-220 has anti-tumor activity .
loading...
    loading...
Cat. No.: HY-P72368
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IgG receptor FcRn; Neonatal Fc receptor; FcRn
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P704603
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IgG receptor FcRn; Neonatal Fc receptor; FcRn
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P11786
CAS No.: 1020264-43-0
Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

SYN1327 is a monomeric peptide that selectively inhibits the hIgG-hFcRn interaction. SYN1327 binds to soluble human FcRn (shFcRn) with Kd values of 31 nM and 170 nM at pH 6 and 7.4, respectively .
loading...
    loading...
Cat. No.: HY-182476
CAS No.: 1359344-58-3
Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Z223-2027 is a FcRn inhibitor. Z223-2027 competitively blocks the binding of immunoglobulin G (IgG) to FcRn. Z223-2027 can be used in the research of IgG-mediated autoimmune diseases .
loading...
    loading...
Cat. No.: HY-P72192
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_human; FCGRT; FcRn alpha chain; FcRn; FcRn; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P705914
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_human; FCGRT; FcRn alpha chain; FcRn; FcRn; alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor; intestinal; heavy chain; Neonatal Fc receptor
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P71664
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Alpha chain; Fc fragment of IgG; receptor transporter; alpha; FCGRN_human; FCGRT; FcRn alpha chain; FcRn; FcRnNeonatal Fc receptor
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-187394
CAS No.: 1425050-80-1
Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

hIgG-hFc receptor-IN-3 is a protein-protein interaction inhibitor of human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn). Identified via virtual ligand screening and optimized through structure-activity relationship studies, hIgG-hFc receptor-IN-3 competitively inhibits the binding of IgG to FcRn, thereby accelerating the clearance of endogenous IgG. hIgG-hFc receptor-IN-3 can be used for the research of autoimmune diseases .
loading...
    loading...
Cat. No.: HY-P73522
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin
Species:  
Source:  
loading...
    loading...
Cat. No.: HY-P705300
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FCGRT-B2M Heterodimer Protein; IgG receptor FcRn large subunit p51; Beta-2-microglobulin
Species:  
Source:  
loading...
    loading...
  • 1