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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
46 Results for "
human carboxylesterase
" in MedChemExpress (MCE) Product Catalog:
Products (46)
46 Results for "human carboxylesterase" in MCE Product Catalog:
13
13 Publications Verification
Cat. No.: HY-B0418A
CAS No.: 34552-83-5
Synonyms: R-18553 hydrochloride
Target:
Research Areas:
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .
2
Category:
Monophenols Leguminosae Phenols Psoralea corylifolia L. Plants Disease Research Fields Cancer
Target:
2
Research Areas:
Bis(4-nitrophenyl) phosphate (BNPP) is an esterase inhibitor, inhibits the activity of esterases such as carboxylesterase. Bis(4-nitrophenyl) phosphate inhibits the degradation of Abiraterone in fresh plasma. Bis(4-nitrophenyl) phosphate can be used as a substrate to determine the enzymatic activity of phosphodiesterase in the roots of wetland plants. Bis(4-nitrophenyl) phosphate also acts as a catalyst for metallomicelles and a catalyst that promotes ring-opening polymerization (ROP) .
2
2 Cited Publications
Cat. No.: HY-B0384
CAS No.: 110221-44-8
Research Areas:
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .
2
2 Cited Publications
Research Areas:
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .
2
1
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
1
1 Cited Publications
Cat. No.: HY-P79357
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NOTUM; HNOTUM; Notum, Palmitoleoyl-Protein carboxylesterase; Notum Pectinacetylesterase Homolog (Drosophila); [Wnt Protein] O-Palmitoleoyl-L-Serine Hydrolase; Notum Pectinacetylesterase Homolog; Palmitoleoyl-Protein carboxylesterase NOTUM; Protein Notum H
Species:
Human
Source:
CHO
Cat. No.: HY-N3677
CAS No.: 14351-29-2
Cat. No.: HY-N1377
CAS No.: 10176-66-6
Synonyms: Lysionotin
Synonyms: Ro 15-3890
Target:
Research Areas:
Flumazenil acid (Ro 15-3890) is a metabolite of Flumazenil (HY-B0009). Flumazenil serves as a diagnostic agent for benzodiazepine poisoning .
Cat. No.: HY-N10686
CAS No.: 61077-78-9
Target:
Cat. No.: HY-N3474
CAS No.: 94805-83-1
Category:
Flavonols other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields
Target:
Target:
Research Areas:
6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) is a metabolite of Hexamethylene bisacetamide (HMBA) (HY-124284) with anti-pulmonary fibrosis activity. 6-Acetamidohexanoic acid does not induce differentiation of human promyelocytic leukemia cells, but is taken up by such cells. 6-Acetamidohexanoic acid serves as a carboxylic acid substrate component for constructing carboxylesterase-responsive near-infrared phototheranostic probes. 6-Acetamidohexanoic acid is applicable to research related to pulmonary fibrosis, refractory hypoxemia and cervical cancer .
Cat. No.: HY-B0418AR
CAS No.: 34552-83-5
Synonyms: R-18553 hydrochloride (Standard)
Research Areas:
Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .
Cat. No.: HY-N0855
CAS No.: 155521-46-3
Synonyms: Alisol-G; 25-Anhydroalisol A
Category:
Triterpenes Alisma plantago-aquatica Linn. Terpenoids Other Diseases Plants Alismataceae Disease Research Fields
Target:
Cat. No.: HY-E70599
Target:
Research Areas:
Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome .
Cat. No.: HY-169323
CAS No.: 2921735-87-5
Synonyms: Mal-Exo-EEVC-MMAE
Target:
Research Areas:
APL-1091 (Mal-Exo-EEVC-MMAE) is an ADC payload-linker conjugate (Drug-Linker Conjugates for ADC). APL-1091 is formed by the conjugation of the Mal-Exo-EEVC (HY-169353) linker and MMAE (HY-15162), a microtubule inhibitor. APL-1091 resists aggregation at high drug-to-antibody ratio (DAR), exhibits excellent plasma stability, and reduces premature payload release. When conjugated with Trastuzumab (HY-P9907), APL-1091 displays anti-tumor activity in gastric cancer xenograft models. APL-1091 can be used for ADC synthesis and gastric cancer-related research .
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Research Areas:
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A) with IC50 values of 2.13 µM and 0.055 µM against PL and hCES1A .
Target:
Research Areas:
1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with Kis of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
