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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
isolated guinea pig ileum
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "isolated guinea pig ileum" in MCE Product Catalog:
Cat. No.: HY-P0242
CAS No.: 86933-75-7
Cat. No.: HY-P0242A
CAS No.: 101536-55-4
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
Synonyms: Picolamine; 3-Pyridinemethanamine; Pyridin-3-ylmethanamine
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3-Picolylamine is a primary amine compound containing a pyridine ring structure. 3-Picolylamine inhibits histaminase (diamine oxidase) activity in pig kidneys. 3-Picolylamine significantly enhances the contractile response of isolated guinea pig ileum to Histamine (HY-B1204). 3-Picolylamine can be used to study histamine-related physiological mechanisms or allergic diseases (such as histamine-mediated inflammatory responses) .
Synonyms: SQ 14551
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Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research .
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SB-203186 hydrochloride is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively .
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Cat. No.: HY-203084
CAS No.: 13270-56-9
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(S)-6-Methylnicotine is a nicotinic acetylcholine receptor (nAChR) agonist that exhibits agonistic activity on isolated guinea pig ileum. (S)-6-Methylnicotine produces sensations identical to those of nicotine and has addictive potential. (S)-6-Methylnicotine shows high cytotoxicity against human bronchial epithelial cells and exerts a weak effect on the upregulation of lung cancer-related proteins. (S)-6-Methylnicotine can be used in the research of respiratory system diseases .
Cat. No.: HY-N3136
CAS No.: 53823-02-2
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Cat. No.: HY-N8671R
CAS No.: 256520-90-8
Category:
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Cat. No.: HY-164010
CAS No.: 607737-00-8
Research Areas:
SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC50 of 20.3 nM and Ki of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC50 of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs .
Cat. No.: HY-130138A
CAS No.: 82948-88-7
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(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .
Cat. No.: HY-130138B
CAS No.: 129263-59-8
Synonyms: (5S,6R)-(11E)-DiHETE
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(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC50 of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .
Cat. No.: HY-N17361
CAS No.: 160954-12-1
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Cat. No.: HY-N11727
CAS No.: 137810-40-3
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Cat. No.: HY-182557
CAS No.: 148490-22-6
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KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC50 of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC50 of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC50 of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma .
Cat. No.: HY-N21792
CAS No.: 213842-42-3
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Cat. No.: HY-Y0047S
Synonyms: Picolamine-d2; 3-Pyridinemethanamine-d2; Pyridin-3-ylmethanamine-d2
Cat. No.: HY-183921
CAS No.: 135100-65-1
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SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation .
Cat. No.: HY-180401
CAS No.: 139964-19-5
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DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC50 = 6 nM) over AT2 (IC50 >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
