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isolated guinea pig ileum

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By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Angiotensin Receptor (1) Biochemical Assay Reagents (1) Calcium Channel (1) Dopamine Receptor (1) Drug Derivative (2) Drug Isomer (1) Histamine Receptor (2) Leukotriene Receptor (2) Lipoxygenase (1) Reference Standards (1) Sigma Receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (6) Endocrinology (1) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0047

3-Picolylamine Picolamine; 3-Pyridinemethanamine; Pyridin-3-ylmethanamine	Biochemical Assay Reagents	Inflammation/Immunology
3-Picolylamine is a primary amine compound containing a pyridine ring structure. 3-Picolylamine inhibits histaminase (diamine oxidase) activity in pig kidneys. 3-Picolylamine significantly enhances the contractile response of isolated guinea pig ileum to Histamine (HY-B1204). 3-Picolylamine can be used to study histamine-related physiological mechanisms or allergic diseases (such as histamine-mediated inflammatory responses) .

HY-123068

Captopril disulfide SQ 14551	Drug Derivative	Cardiovascular Disease
Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research .

HY-101222

SB-203186 hydrochloride	5-HT Receptor	Cardiovascular Disease Neurological Disease
SB-203186 hydrochloride is a potent, selective and competitive 5-HT₄ antagonist. SB-203186 hydrochloride antagonizes the 5-HT₄ receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pK_B values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively .

HY-N12520

Helveticoside Strophanthidin-digitoxoside	Others	Metabolic Disease Cancer
Helveticoside (Strophanthidin-digitoxoside) is a helveticosid, possesses an ED₅₀ of 0.17 μM for isolated guinea-pig ileum. Helveticoside has anticancer effect .

HY-N3136

Onitin	Histamine Receptor	Others
Onitin is a natural product, that can be isolated from Onychium siliculosum. Onitin is also a non-competitive antagonist of histamine. Onitin shows activity in blocking the peristaltic reflex of the guinea-pig ileum, in inhibition of the responses of guinea-pig ileum to histamine and of inhibition of the responses of guinea-pig tracheal muscle to histamine .

HY-N8671R

Withanoside V (Standard)	Reference Standards Others	Neurological Disease
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-164010

SUN-1334H free base	Histamine Receptor Dopamine Receptor Adrenergic Receptor Sigma Receptor	Cardiovascular Disease Inflammation/Immunology
SUN-1334H free base is an orally active inhibitor for histamine H1 receptor, with an IC₅₀ of 20.3 nM and K_i of 9.7 nM. SUN-1334H free base inhibits histamine-induced contractions of isolated guinea-pig ileum with an IC₅₀ of 0.198 μM. SUN-1334H free base inhibits histamine-induced bronchoconstriction in guinea pigs, histamine-induced skin wheals in beagle dogs, and ovalbumin-induced rhinitis in guinea pigs .

HY-130138A

(5S,6R)-DiHETE	Leukotriene Receptor	Inflammation/Immunology
(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-130138B

(5S,6R)-DiHETEs (5S,6R)-(11E)-DiHETE	Leukotriene Receptor	Inflammation/Immunology
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-N17361

Methylgerambullone	Drug Isomer	Endocrinology
Methylgerambullone is a constitutional isomer of Methylisogerambullone. Methylgerambullone can be isolated from the methanolic leaf extract of Glycosmis angustifolia. Methylgerambullone shows the relaxatory effect on guinea-pig isolated ileum precontracted with Acetylcholine .

HY-N11727

Boeravinone F	Drug Derivative	Inflammation/Immunology
Boeravinone F is a Rotenoid derivative. Boeravinone F can be isolated from Boerhaavia diffusa and Boerhavia repens. Boeravinone F inhibits Acetylcholine-induced contraction of isolated guinea pig ileum .

HY-182557

KC-11404	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
KC-11404 is an orally active antihistamine and 5-lipoxygenase inhibitor, with an IC₅₀ of 0.9 μM against guinea pig 5-lipoxygenase. KC-11404 inhibits histamine-induced contraction of isolated guinea pig ileum with an IC₅₀ of 0.26 μM. KC-11404 inhibits PAF-induced rabbit platelet aggregation with an IC₅₀ of 2.0 μM. It inhibits the histamine phase of antigen-induced bronchoconstriction and PAF-induced bronchoconstriction in guinea pigs. KC-11404 can be used for the research of asthma .

HY-183921

SQ 32547	Calcium Channel	Cardiovascular Disease Inflammation/Immunology
SQ 32547 is a dihydropyridine calcium channel inhibitor with antihypertensive and anti-ischemic activities. SQ 32547 modulates sarcolemmal voltage-dependent calcium channels to inhibit calcium influx, and exerts direct anti-ischemic activity by suppressing myocardial contracture formation and reducing lactate dehydrogenase (LDH) release. SQ 32547 can be used in research related to hypertension, angina pectoris and neurogenic inflammation .

HY-180401

DMP 811	Angiotensin Receptor	Cardiovascular Disease
DMP 811 is a potent, orally active and selective angiotensin II subtype receptor AT1 antagonist. DMP 811 exhibits selectivity for AT1 (IC₅₀ =6 nM) over AT2 (IC₅₀ >10 μM). DMP 811 exhibits potent antihypertensive activity in rats and dogs. DMP 811 can be used for the research of hypertension .

Helveticoside Strophanthidin-digitoxoside	Structural Classification Senegalia pennata (L.) Maslin Cardiacglycosides Labiatae Plants Steroids Source Classification	Others
Helveticoside (Strophanthidin-digitoxoside) is a helveticosid, possesses an ED₅₀ of 0.17 μM for isolated guinea-pig ileum. Helveticoside has anticancer effect .

Onitin	Monophenols Onychium siliculosum (Desv.) C. Chr. Sinopteridaceae Phenols Plants Source Classification	Histamine Receptor
Onitin is a natural product, that can be isolated from Onychium siliculosum. Onitin is also a non-competitive antagonist of histamine. Onitin shows activity in blocking the peristaltic reflex of the guinea-pig ileum, in inhibition of the responses of guinea-pig ileum to histamine and of inhibition of the responses of guinea-pig tracheal muscle to histamine .

Withanoside V (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards Others
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

Methylgerambullone	Structural Classification Natural Products Rutaceae Plants Glycosmis angustifolia Lindl. ex Wight & Arn. Source Classification	Drug Isomer
Methylgerambullone is a constitutional isomer of Methylisogerambullone. Methylgerambullone can be isolated from the methanolic leaf extract of Glycosmis angustifolia. Methylgerambullone shows the relaxatory effect on guinea-pig isolated ileum precontracted with Acetylcholine .

Boeravinone F	Structural Classification Phenols Polyphenols Nyctaginaceae Plants Boerhavia repens Linnaeus Source Classification	Drug Derivative
Boeravinone F is a Rotenoid derivative. Boeravinone F can be isolated from Boerhaavia diffusa and Boerhavia repens. Boeravinone F inhibits Acetylcholine-induced contraction of isolated guinea pig ileum .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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isolated guinea pig ileum

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