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mUC

" in MedChemExpress (MCE) Product Catalog:

94

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1

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4

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9

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24

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39

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2

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42

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40

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99634

    PankoMab; DS-3939a antibody

    Mucin Cancer
    Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) .
    Gatipotuzumab
  • HY-B1203

    9α-Fludrocortisone; 9α-Fluorcortisol

    Mineralocorticoid Receptor Glucocorticoid Receptor Apoptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Fludrocortisone (9α-Fludrocortisone) is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency .
    Fludrocortisone
  • HY-P99539

    REGN4018

    CD3 Cancer
    Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity .
    Ubamatamab
  • HY-P1925A
    GO-203 TFA
    2 Publications Verification

    PI3K Reactive Oxygen Species (ROS) Apoptosis Cancer
    GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .
    GO-203 TFA
  • HY-177442

    DS-3939

    Antibody-Drug Conjugates (ADCs) Mucin Topoisomerase Apoptosis Cancer
    DS-3939a (DS-3939) is an anti-TA-MUC1 (tumor-associated mucin-1) antibody-drug conjugate (ADC). DS-3939a consists of a humanized anti-TA-MUC1 IgG1 monoclonal antibody Gatipotuzumab ( HY-P99634), a stable and cleavable tetrapeptide-based linker (Gly-Gly-Phe-Gly), and a DNA topoisomerase I inhibitor payload (DXd) (HY-13631D), and the drug-linker conjugate for ADC is Deruxtecan (HY-13631E). DS-3939a inhibits the growth of TA-MUC1-positive cancer cells (CFPAC-1, NCI-H2110) by inducing DNA damage and apoptosis. DS-3939a exhibits significant antitumor activity in a variety of TA-MUC1-expressing advanced solid tumors. DS-3939a can be used for the study of TA-MUC1-expressing advanced cancers .
    DS-3939a
  • HY-N2609
    7,4'-Dihydroxyflavone
    4 Publications Verification

    COX CCR NF-κB Inflammation/Immunology Endocrinology
    7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
    7,4'-Dihydroxyflavone
  • HY-P99384

    B-701; MFGR-1877S; RG-7444

    FGFR Cancer
    Vofatamab (B-701) is an anti-FGFR3 monoclonal antibody (mAb). Vofatamab blocks activation of both the wildtype and genetically activated receptor. Vofatamab can be used in the research of metastatic urothelial carcinoma (mUC). Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .
    Vofatamab
  • HY-100958
    4-DAMP
    4 Publications Verification

    4-DAMP methiodide

    mAChR Apoptosis MMP EGFR Interleukin Related Inflammation/Immunology Cancer
    4-DAMP (4-DAMP methiodide) is a potent and selective antagonist of M3 receptors and also has a high affinity for the closely-related M5 receptors. 4-DAMP combined with 5-Fluorouracil (5-Fu) (HY-90006) could significantly reduce the cell viability and enhance apoptosis in MKN45 and BGC823 gastric cancer cells. 4-DAMP inhibits lipopolysaccharide (LPS)- and tobacco-induced pulmonary inflammation and reduces mucin 5AC (MUC5AC), oligomeric mucus/gel-forming secretion .
    4-DAMP
  • HY-NP159

    Mucin Interleukin Related Inflammation/Immunology
    House Dust Mite Extract, from D.farinae is a house dust mite allergen extract derived from Dermatophagoides farinae. House Dust Mite Extract, from D.farinae significantly increases the levels of cytokines (IL-4, IL-5, IL-6) in bronchoalveolar lavage fluid. House Dust Mite Extract, from D.farinae upregulates the overexpression of MUC5AC. House Dust Mite Extract, from D.farinae induces allergic asthma and pulmonary inflammation .
    House Dust Mite Extract, from D.farinae
  • HY-E70562

    Bacterial Infection Cancer
    Mucinase StcE is a zinc metalloproteinase belonging to the M66 family, which is secreted by enterohemorrhagic Escherichia coli via the type II general secretion pathway. Mucinase StcE specifically recognizes and cleaves the 'T*XT' motif in mucin-type glycoproteins with α-O-glycans (such as MUC2, Mucin 7, Glycoprotein 340, CD45, CD43, C1 Esterase Inhibitor (HY-P991629), etc.). By degrading the mucus layer to reduce its viscosity, inhibiting complement cascade activation, and localizing complement regulatory factors to the cell membrane, Mucinase StcE helps bacteria penetrate the mucosal barrier, adhere to host cells, and evade immune clearance. Mucinase StcE can serve as a mucin-specific proteolytic tool for research on mucinous carcinomas derived from the colon, esophagus, and salivary glands .
    Mucinase StcE
  • HY-B0393
    Fudosteine
    1 Publications Verification

    Amino Acid Derivatives Inflammation/Immunology
    Fudosteine is a cysteine derivative and a mucoactive agent. Fudosteine inhibits MUC5AC mucin hypersecretion by reducing MUC5AC gene expression .
    Fudosteine
  • HY-P99237

    MmUC 1206A

    Mucin Cancer
    Sofituzumab (MMUC 1206A) is an anti-MUC16 antibody with a Kd of 0.3-0.9 nM. Sofituzumab can bind multiple adjacent antibody molecules to the repeat sequences of the same MUC16 molecule. Sofituzumab exhibits no anti-tumor activity in the HPAC pancreatic adenocarcinoma xenograft model .
    Sofituzumab
  • HY-N2098
    Obtusifolin
    4 Publications Verification

    NF-κB Cancer
    Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway . Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein .
    Obtusifolin
  • HY-P99523

    AMG 199

    CD3 Cancer
    Vepsitamab (AMG 199) is a bispecific T-cell engager (HLE BiTE) that binds to MUC17 and CD3. Vepsitamab directs CD3-positive cells to target MUC17-positive cells. Vepsitamab induces cell activation and proliferation. Vepsitamab is applicable to research related to gastric cancer and gastroesophageal junction (g/gej) cancer .
    Vepsitamab
  • HY-P99591

    AS1402; huHMFG-1; Epitumomab

    Mucin Cancer
    Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer .
    Sontuzumab
  • HY-P99593

    DmUC5754A

    Antibody-Drug Conjugates (ADCs) Cancer
    Sofituzumab vedotin (DMUC5754A) is a MMAE-containing anti-MUC16 antibody-drug conjugate (ADC) with a protease-cleavable linker. Sofituzumab vedotin can be used for the research of cancer .
    Sofituzumab vedotin
  • HY-N1510

    Glycosidase Notch Toll-like Receptor (TLR) NF-κB Mucin Reactive Oxygen Species (ROS) Bacterial TGF-beta/Smad Anaplastic lymphoma kinase (ALK) Infection Inflammation/Immunology Cancer
    Kaempferol 3-O-gentiobioside is an orally active flavonoid, with a Ka value of 57 µM against human NOTCH1 and an IC50 value of 50 μM against α-glucosidase. Kaempferol 3-O-gentiobioside inhibits the NOTCH signaling pathway. It downregulates the expression of TLR4 and NLRP3, and suppresses the activation and nuclear translocation of NF-κB. Kaempferol 3-O-gentiobioside inhibits the expression of MUC5AC, reduces nitrite and ROS levels, and attenuates excessive mucus secretion. It exhibits antibacterial activity, reducing the formation and growth of MRSA biofilms. Kaempferol 3-O-gentiobioside blocks the TGF-β/ALK5/Smad signaling pathway and inhibits epithelial-mesenchymal transition. It suppresses the proliferation, migration, invasion and metastatic growth of tumor cells. Kaempferol 3-O-gentiobioside alleviates airway inflammation and mucus hypersecretion in mice with allergic asthma . It reduces the volume of ovarian cancer xenografts in mice. Kaempferol 3-O-gentiobioside can be used in research related to allergic asthma, diabetes, MRSA infection, breast cancer, gastric cancer and ovarian cancer .
    Kaempferol 3-O-gentiobioside
  • HY-P2508

    Mucin Cancer
    MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .
    MUC1, mucin core
  • HY-160062

    Mucin Cancer
    S2.2 aptamer sodium is a nucleic acid-based MUC1-binding aptamer with high affinity and low toxicity. Upon binding to its target, S2.2 aptamer sodium undergoes a conformational switch and restores fluorescence signal, serving as a targeted imaging agent for MUC1-positive cancer cells. S2.2 aptamer sodium enables targeted delivery to breast cancer cells with overexpressed MUC1. When formulated as the S2.2-PEG-MZF molecular probe, S2.2 aptamer sodium possesses the functions of T2 signal inhibition, magnetic field-induced hyperthermia and targeted magnetic resonance molecular imaging. In the S2.2-PEG-MZF/DOX nanoliposome, S2.2 aptamer sodium supports targeted thermochemotherapy, effectively inhibiting cancer cell proliferation and invasion as well as inducing apoptosis, and is widely used in studies related to breast cancer .
    S2.2 aptamer sodium
  • HY-P99968

    Mucin Cancer
    Clivatuzumab is a humanized anti-mucin monoclonal antibody targeting an epitope in the MUC1 antigen expressed in most pancreatic cancers .
    Clivatuzumab
  • HY-168973

    AER-01; mUC-031

    Mucin Inflammation/Immunology
    Fexlamose (AER-01) is a thiol-modified carbohydrate agent with mucolytic property. Fexlamose cleaves disulfides to cause mucolysis. Fexlamose can be used for researchs of chronic obstructive pulmonary disease (COPD) and muco-obstructive lung diseases (MOLD) .
    Fexlamose
  • HY-P990831

    Mucin Cancer
    Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a kind of mouse IgG3 κ chimeric antibody inhibitor, targeting to human MUC1/CD227. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) specifically recognizes and binds to the MUC1 protein, which is overexpressed and abnormally glycosylated on the surface of tumor cells, thereby precisely killing cancer cells. Anti-MUC1/CD227 Antibody (C595 (NCRC48)) can be used for the researches of cancer, such as ovarian cancer .
    Anti-MUC1/CD227 Antibody (C595 (NCRC48))
  • HY-P0280

    Mucin Inflammation/Immunology Cancer
    MUC5AC motif peptide is a 16-amino acid fragment of mucin 5.
    MUC5AC motif peptide
  • HY-E70290

    GALNT1

    Endogenous Metabolite β-catenin Wnt Cancer
    N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .
    N-Acetylgalactosaminyltransferase 1
  • HY-P99362

    Anti-mUC5AC Reference Antibody (ensituximab); NEO-102

    Mucin Cancer
    Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer .
    Ensituximab
  • HY-P991609

    MMP Cancer
    ABX-MA1 is a humanized IgG2 monoclonal antibody inhibitor targeting MCAM/MUC18. ABX-MA1 significantly decreases homotypic aggregation and heterotypic adhesion to HUVECs, and the formation of experimental lung metastasis. ABX-MA1 potently inhibits tumor growth, angiogenesis, and MMP-2 expression in A375SM/WM2664 xenograft mice model, promising for melanoma research .
    ABX-MA1
  • HY-P1925B

    Mucin Cancer
    L-GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. L-GO-203 TFA is an anti-cancer peptide for targeting intracellular proteins .
    L-GO-203 TFA
  • HY-P10701

    Biochemical Assay Reagents Inflammation/Immunology Cancer
    Q11 peptide is a β-sheet-forming peptide that plays an important role in self-assembly and targeted applications. As a scaffold peptide, Q11 peptide can display immunogenic epitopes and is widely used in peptide-based immune vaccine research. Additionally, Q11 peptide can be conjugated with MUC1 glycopeptides for the study of self-assembling, adjuvant-free MUC1 glycopeptide vaccines. Q11 peptide holds great potential for research in the field of cancer immunology .
    Q11 peptide
  • HY-117616

    (+)-Laurotetanine

    NF-κB Cancer
    Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways .
    Laurotetanine
  • HY-RS19923

    Small Interfering RNA (siRNA) Others

    Muc4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Muc4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Muc4 Mouse Pre-designed siRNA Set A
    Muc4 Mouse Pre-designed siRNA Set A
  • HY-160060

    Mucin Cancer
    MA3 aptamer sodium is an 86-base long DNA aptamer targeting the mucin MUC1. MA3 aptamer sodium binds to the peptide epitope of mucin 1 (MUC1) with a Kd of 38.3 nM and has minimal cross-reactivity with albumin .
    MA3 aptamer sodium
  • HY-P991166

    Mucin Others
    Ubletamig is an anti-MUC16 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003) .
    Ubletamig
  • HY-N2609R

    COX Reference Standards CCR NF-κB Inflammation/Immunology Endocrinology
    7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid, which can be isolated from Glycyrrhiza uralensis. 7,4'-Dihydroxyflavone is eotaxin/CCL11 inhibitor and CBR1 inhibitor (IC50=0.28 μM). 7,4'-Dihydroxyflavone has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production . 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM .
    7,4'-Dihydroxyflavone (Standard)
  • HY-P991102

    CD3 Cancer
    Anti-MUC17 Antibody is a human antibody expressed in CHO cells, targeting MUC17. Anti-MUC17 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-MUC17 Antibody
  • HY-P990830

    Mucin Cancer
    Anti-MUC16 Antibody (VK8) is a kind of mouse IgG1 κ chimeric antibody inhibitor, targeting to human MUC16. Anti-MUC16 Antibody (VK8) reacts with human MUC16 also known as carbohydrate antigen 125 (CA125). Anti-MUC16 Antibody (VK8) Anti-MUC16 Antibody (VK8) can be used for detection of tumor marker, such as ovarian cancer .
    Anti-MUC16 Antibody (VK8)
  • HY-P5472

    Transmembrane Glycoprotein Others
    Tumour-associated MUC1 epitope is a biological active peptide. (This sequence is the hallmark of MUC1 mucin. MUC1 is a highly glycosylated type I transmembrane glycoprotein with a unique extracellular domain consisting of a variable number of tandem repeats (VNTR) of this 20 amino acid peptide. It is overexpressed on the cell surface of many human adenocarcinomas and hematological malignancies, including multiple myeloma and B-cell lymphoma, making MUC1 broadly applicable target for immunotherapeutic strategies.)
    Tumour-associated MUC1 epitope
  • HY-RS18669

    Small Interfering RNA (siRNA) Others

    Muc17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Muc17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Muc17 Mouse Pre-designed siRNA Set A
    Muc17 Mouse Pre-designed siRNA Set A
  • HY-RS08839

    Small Interfering RNA (siRNA) Others

    MUC20 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC20 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC20 Human Pre-designed siRNA Set A
    MUC20 Human Pre-designed siRNA Set A
  • HY-RS08841

    Small Interfering RNA (siRNA) Others

    MUC22 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC22 Human Pre-designed siRNA Set A
    MUC22 Human Pre-designed siRNA Set A
  • HY-RS08848

    Small Interfering RNA (siRNA) Others

    MUC8 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC8 Human Pre-designed siRNA Set A
    MUC8 Human Pre-designed siRNA Set A
  • HY-RS08831

    Small Interfering RNA (siRNA) Others

    MUC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC1 Human Pre-designed siRNA Set A
    MUC1 Human Pre-designed siRNA Set A
  • HY-RS08837

    Small Interfering RNA (siRNA) Others

    MUC19 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC19 Human Pre-designed siRNA Set A
    MUC19 Human Pre-designed siRNA Set A
  • HY-RS08846

    Small Interfering RNA (siRNA) Others

    MUC6 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC6 Human Pre-designed siRNA Set A
    MUC6 Human Pre-designed siRNA Set A
  • HY-RS23304

    Small Interfering RNA (siRNA) Others

    Muc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Muc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Muc1 Rat Pre-designed siRNA Set A
    Muc1 Rat Pre-designed siRNA Set A
  • HY-RS29170

    Small Interfering RNA (siRNA) Others
    Muc13 Rat Pre-designed siRNA Set A contains three designed siRNAs for Muc13 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Muc13 Rat Pre-designed siRNA Set A
    Muc13 Rat Pre-designed siRNA Set A
  • HY-RS08836

    Small Interfering RNA (siRNA) Others

    MUC17 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC17 Human Pre-designed siRNA Set A
    MUC17 Human Pre-designed siRNA Set A
  • HY-RS08832

    Small Interfering RNA (siRNA) Others

    MUC12 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC12 Human Pre-designed siRNA Set A
    MUC12 Human Pre-designed siRNA Set A
  • HY-RS08840

    Small Interfering RNA (siRNA) Others

    MUC21 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC21 Human Pre-designed siRNA Set A
    MUC21 Human Pre-designed siRNA Set A
  • HY-RS08847

    Small Interfering RNA (siRNA) Others

    MUC7 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC7 Human Pre-designed siRNA Set A
    MUC7 Human Pre-designed siRNA Set A
  • HY-RS08843

    Small Interfering RNA (siRNA) Others

    MUC4 Human Pre-designed siRNA Set A contains three designed siRNAs for MUC4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MUC4 Human Pre-designed siRNA Set A
    MUC4 Human Pre-designed siRNA Set A

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