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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
mecA
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "mecA" in MCE Product Catalog:
10
10 Publications Verification
Synonyms: IB-mecA; CF-101
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Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19 .
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3 Cited Publications
Synonyms: CF-102; 2-Cl-IB-mecA
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Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .
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1 Cited Publications
Cat. No.: HY-19365
CAS No.: 152918-26-8
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AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level .
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MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R .
Cat. No.: HY-178783
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MRS8454 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR). MRS8454 can significantly enhance the maximum effect of the standard agonist Cl-IB-MECA by approximately 286%-300%, and significantly reduce its EC50 value. MRS8454 effectively enhances the ability of A3AR agonists to inhibit the cAMP accumulation induced by Forskolin (HY-15371). MRS8454 can be used for the development of molecular probes .
Cat. No.: HY-P990197
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Cat. No.: HY-P990174
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Cat. No.: HY-124259
CAS No.: 152918-27-9
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I-AB-MECA is an important radioligand for the study of A3 adenosine receptors (A3AR) .
Cat. No.: HY-12365R
CAS No.: 163042-96-4
Synonyms: CF-102 (Standard); 2-Cl-IB-mecA (Standard)
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Namodenoson (Standard) is the analytical standard of Namodenoson. This product is intended for research and analytical applications. Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (Ki=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .
Cat. No.: HY-151899
CAS No.: 2991693-62-8
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A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [ 35S]GTPγS binding Emax .
Cat. No.: HY-162787
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Adenosine receptor antagonist 5 (Compound 39) is a selective antagonist for human adenosine A3 receptor (hA3R) with Ki of 12 nM. Adenosine receptor antagonist 5 inhibits IB-MECA (HY-13591)-induced cAMP accumulation in NCI-H1792 cell, inhibits the proliferation of cancer cell LK-2 and NCI-H1792. Adenosine receptor antagonist 5 exhibits a fast metabolic rate in human liver microsomes .
Cat. No.: HY-178108
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Anti-MRSA agent 35 (Compound 6b) is an anti-MRSA agent. Anti-MRSA agent 35 significantly inhibits MRSA biofilm formation, suppresses penicillin-binding protein (PBP2a) expression and induces mecA virulence gene mutation. Anti-MRSA agent 35 has potent bactericidal and fungicidal activities with MIC50s of 7.8-31.25 μg/mL for gram positive bacteria, gram-negative bacteria and Fungi. .
Cat. No.: HY-119191
CAS No.: 206129-88-6
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KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma .
Cat. No.: HY-P991807
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Cat. No.: HY-P701337
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BCAT1; Branched-Chain-Amino-Acid Aminotransferase; Prev. BCT1; Alternative Protein BCAT1; BCATc; Placental Protein 18; Branched-Chain-Amino-Acid Aminotransferase, Cytosolic; PNAS121; Branched Chain Aminotransferase 1, Cytosolic; BCAT(C); ECA39; mecA39; Br
Species:
Human
Source:
E. coli
Cat. No.: HY-P701338
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BCAT1; Branched-Chain-Amino-Acid Aminotransferase; Prev. BCT1; Alternative Protein BCAT1; BCATc; Placental Protein 18; Branched-Chain-Amino-Acid Aminotransferase, Cytosolic; PNAS121; Branched Chain Aminotransferase 1, Cytosolic; BCAT(C); ECA39; mecA39; Br
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
