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Results for "

pancreatic lipase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Lipase (47) Akt (1) Amylases (4) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (8) ATP Synthase (1) Autophagy (3) Bacterial (3) Biochemical Assay Reagents (2) Carboxylesterase (CES) (2) Caspase (1) Cholinesterase (ChE) (1) Dipeptidyl Peptidase (1) Drug Derivative (2) Drug Metabolite (2) Endogenous Metabolite (2) Fatty Acid Synthase (FASN) (3) Ferroptosis (1) Fluorescent Dye (1) Free Fatty Acid Receptor (1) Fungal (1) GLUT (1) Glycosidase (3) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) MMP (1) NF-κB (2) NOD-like Receptor (NLR) (1) P2Y Receptor (1) p38 MAPK (1) PI3K (1) PPAR (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) SARS-CoV (1) SOD (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (4) Metabolic Disease (47)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Lipase DAGL MAGL Hormone-Sensitive Lipase (HSL) ATGL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0218

Orlistat Maximum Cited Publications 32 Publications Verification Tetrahydrolipstatin; Ro-18-0647	Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity . Anti-atherosclerotic effect .

HY-B0998

Dehydrocholic acid sodium Dehydrocholate sodium	Amylases Lipase Autophagy	Metabolic Disease
Dehydrocholic acid (Dehydrocholate) sodium is an orally active hydrocholeretic agent. Dehydrocholic acid sodium modulates Autophagy, reduces serum amylase and *lipase* levels. Dehydrocholic acid sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice .

HY-W013168

4-Nitrophenyl palmitate 4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp	Lipase	Others
4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate) is a chromogenic substrate for lipases and esterases. Upon enzymatic hydrolysis, 4-Nitrophenyl palmitate releases p-nitrophenol, which can be quantified by colorimetric detection at 410 nm as a measure of enzymatic activity. 4-Nitrophenyl palmitate is used to characterize the activity of various bacterial and mammalian enzymes, including those from Burkholderia and porcine pancreatic lipase .

HY-N7072

Grape seed extract 2 Publications Verification	Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-14471

Cetilistat 1 Publications Verification ATL-962	Lipase	Metabolic Disease
Cetilistat (ATL-962), an inhibitor of **pancreatic lipase*, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic* lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-126411

Peonidin-3-O-galactoside chloride	Lipase ATP Synthase	Others
Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC₅₀ value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases .

HY-N8599

Cichoriin 2 Publications Verification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB	Infection Metabolic Disease Inflammation/Immunology
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, **pancreatic lipase and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀** = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-117095

4-Methylumbelliferyl oleate	Fluorescent Dye	Metabolic Disease
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm) .

HY-B1393

Dehydrocholic acid Dehydrocholate	Autophagy Amylases Lipase	Metabolic Disease
Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and *lipase* levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice .

HY-110390

GR148672X	Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis	Cardiovascular Disease Cancer
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .

HY-W099648

4-Methylumbelliferyl octanoate	Lipase	Others
4-Methylumbelliferyl octanoate is a octoate. 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase .

HY-B0218R

Orlistat (Standard) Maximum Cited Publications 32 Publications Verification Tetrahydrolipstatin (Standard); Ro-18-0647 (Standard)	Reference Standards Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease Cancer
Orlistat (Standard) is the analytical standard of Orlistat. This product is intended for research and analytical applications. Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity . Anti-atherosclerotic effect .

HY-W127730

Pyridoxine 3,4-dipalmitate	Drug Derivative	Others
Pyridoxine 3,4-dipalmitate is a Pyridoxine (HY-B1328) derivative. Pyridoxine exerts its antioxidant effects .

HY-135297

Mono-and diglycerides	Biochemical Assay Reagents	Others
Mono-and diglycerides is formed by triglycerides being broken down by pancreatic lipase in the gastrointestinal lumen. Mono-and diglycerides is a food additive used as a nonionic emulsifier and mainly present in food fats .

HY-119741

Salacinol	Glycosidase Lipase	Metabolic Disease
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits **pancreatic lipase** and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-Y1422B

Lipase (MS grade) 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner. Lipase (MS grade) is involved in a variety of biological processes, from fat metabolism to cell signaling and inflammation, and can be used to study diseases such as pancreatic insufficiency, celiac disease and cystic fibrosis .

HY-N0555

Escin IB	Lipase	Metabolic Disease
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on **pancreatic lipase** activity .

HY-N4167

3-O-Methylgalangin 1 Publications Verification Galangin 3-methyl ether; 3-Methylgalangin	Bacterial	Infection
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase .

HY-144809

Pancreatic lipase/Carboxylesterase 1-IN-1	Carboxylesterase (CES)	Metabolic Disease
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and human carboxylesterase 1A (hCES1A) with IC₅₀ values of 2.13 µM and 0.055 µM against PL and hCES1A .

HY-N16617

Platycodin V	Lipase	Metabolic Disease
Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.

HY-N3797A

Echitamine chloride Ditaine chloride	Apoptosis	Cancer
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits **pancreatic lipase with an IC₅₀** of 10.92 μM .

HY-N2330

Lipstatin	Lipase	Metabolic Disease
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-W127391

1,2-Dilaurin (Rac)-1,2-Didodecanoylglycerol	Biochemical Assay Reagents	Others
1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

HY-N15385

Hericenone D	Lipase	Metabolic Disease
Hericenone D, an orally active **pancreatic lipase** inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity .

HY-157313

Pancreatic lipase-IN-1	Lipase	Metabolic Disease
Pancreatic lipase-IN-1 (compound 8) ia a **pancreatic lipase inhibitor with the K_i** of 1.288 μM .

HY-131999

3,4,5-Trihydroxycinnamic acid decyl ester	Lipase	Metabolic Disease
3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a **pancreatic lipase inhibitor, with an EC₅₀** of approximately 0.9 μM .

HY-B0218S

Orlistat-d3 Tetrahydrolipstatin-d₃; Ro-18-0647-d₃	Isotope-Labeled Compounds Fatty Acid Synthase (FASN) Apoptosis	Metabolic Disease
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .

HY-N4298

Epitheaflagallin 3-O-gallate	MMP	Metabolic Disease Inflammation/Immunology
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-N12292

Acanthopanaxoside A	Lipase	Metabolic Disease
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-136124

Cetilistat impurity 1	Drug Metabolite	Others
Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of **pancreatic lipase*, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic* lipase activity with IC₅₀s of 54.8 nM, and 5.95 nM, respectively .

HY-Y0606

(+)-Camphor-10-sulfonic acid (+)-10-Camphorsulfonic acid	Lipase	Metabolic Disease
(+)-Camphor-10-sulfonic acid ((+)-10-Camphorsulfonic acid) is an effective pancreatic lipase (PL) inhibitor. (+)-Camphor-10-sulfonic acid is promising for research of obesity .

HY-157534

Pancreatic lipase-IN-2	Lipase	Metabolic Disease
Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC₅₀ value of 2.67 μM, that has anti-obesity effect .

HY-138959

4-Nitrophenyl octanoate p-Nitrophenyl caprylate	Lipase	Others
4-Nitrophenyl octanoate (p-Nitrophenyl caprylate) is an aromatic ester compound which can be used as a substrate for pancreatic lipase. 4-Nitrophenyl octanoate contains an ester bond that can be hydrolyzed under the action of lipase, releasing p-nitrophenol as a yellow product. 4-Nitrophenyl octanoate can be used to assay the activities of lipases and esterases .

HY-N12296

Ciwujianoside C4	Lipase	Metabolic Disease
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12294

Ciwujianoside D2	Lipase	Metabolic Disease
Ciwujianoside D2, a saponin compound, can enhance **pancreatic lipase** activity in vitro .

HY-N12297

Ciwujianoside C2	Lipase	Others
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N8362

1-Isomangostin	Lipase	Metabolic Disease
1-Isomangostin is an inhibitor of **pancreatic lipase*. 1-Isomangostin inhibits porcine pancreatic* lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N12298

Ciwujianoside C1	Lipase	Others
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-14471R

Cetilistat (Standard) ATL-962 (Standard)	Lipase Reference Standards	Metabolic Disease
Cetilistat (Standard) is the analytical standard of Cetilistat. This product is intended for research and analytical applications. Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively .

HY-N7163

(2S)-5,7,3',5'-Tetrahydroxyflavanone (2S)-3',5,5'7-Tetrahydroxyflavanone	Lipase	Others
(2S)-5,7,3',5'-Tetrahydroxyflavanone ((2S)-3',5,5'7-Tetrahydroxyflavanone) is a porcine pancreatic lipase modulator with an IC₅₀ of >200 μM against porcine pancreatic lipase. (2S)-5,7,3',5'-Tetrahydroxyflavanone interacts with an enzyme involved in triglyceride hydrolysis .

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Glycosidase	Others
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Endogenous Metabolite	Metabolic Disease
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a **pancreatic lipase inhibitor, with an IC₅₀** value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-N14641

Panclicin A	Lipase	Metabolic Disease
Panclicin A is a potent **pancreatic lipase** inhibitor .

HY-N14643

Panclicin C	Lipase	Metabolic Disease
Panclicin C is a potent **pancreatic lipase** inhibitor .

HY-N14647

Panclicin E	Lipase	Metabolic Disease
Panclicin E is a potent **pancreatic lipase** inhibitor .

HY-N14646

Panclicin D	Lipase	Metabolic Disease
Panclicin D is a potent **pancreatic lipase** inhibitor .

HY-N14642

Panclicin B	Lipase	Metabolic Disease
Panclicin B is a potent **pancreatic lipase** inhibitor .

HY-N7668

Neotheaflavin	Lipase	Metabolic Disease
Neotheaflavin, from black tea, inhibits pancreatic lipase .

HY-149506

1,3-Didecanoylglycerol 1,3-Dicaprin	Lipase	Others
1,3-Didecanoylglycerol (1,3-Dicaprin) is a triglyceride analog that can be used as a substrate in pancreatic *lipase* hydrolysis reactions .

HY-155836

hPL-IN-1	Lipase	Metabolic Disease
hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC₅₀=1.86 μM) for anti-obesity research .

Cat. No.	Product Name	Type

HY-W013168

4-Nitrophenyl palmitate

4-Nitrophenyl hexadecanoate; p-Nitrophenyl Palmitate; pNpp

Fluorescent Dyes

4-Nitrophenyl palmitate (4-Nitrophenyl hexadecanoate) is a chromogenic substrate for lipases and esterases. Upon enzymatic hydrolysis, 4-Nitrophenyl palmitate releases p-nitrophenol, which can be quantified by colorimetric detection at 410 nm as a measure of enzymatic activity. 4-Nitrophenyl palmitate is used to characterize the activity of various bacterial and mammalian enzymes, including those from Burkholderia and porcine pancreatic lipase .

Cat. No.	Product Name	Type

HY-W127730

Pyridoxine 3,4-dipalmitate	Biochemical Assay Reagents
Pyridoxine 3,4-dipalmitate is a Pyridoxine (HY-B1328) derivative. Pyridoxine exerts its antioxidant effects .

HY-W127391

1,2-Dilaurin

(Rac)-1,2-Didodecanoylglycerol

Biochemical Assay Reagents

1,2-Dilaurin is a diacylglycerol containing lauric acid at the sn-1 and sn-2 positions. It has been used as an internal standard for the quantification of diglycerides in rat desheathed sciatic nerves. [1] Monomolecular films containing 1,2-dilauroyl-rac-glycerol have been used as substrates to measure surface pressure and the effect of pancreatic procolipase and colipase on porcine pancreatic lipase activity. [2] References: [1]. Zhu, X. and Eichberg, J. 1,2-Diacylglycerol content and its arachidonyl-containing molecular species are reduced in the sciatic nerve of streptozotocin-induced diabetic rats. J. Neurochemistry. 55(3), 1087-1090 (1990).[2]. Wieloch, T., Borgstr m, B., Piéroni, G. et al. Porcine trypsinogen and its trypsin-activated form: lipid binding and lipase activation on monomolecular membranes. FEBS Express. 128(2), 217-220 (1981).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0998

Dehydrocholic acid sodium Dehydrocholate sodium	Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Amylases Lipase Autophagy
Dehydrocholic acid (Dehydrocholate) sodium is an orally active hydrocholeretic agent. Dehydrocholic acid sodium modulates Autophagy, reduces serum amylase and *lipase* levels. Dehydrocholic acid sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice .

HY-N7072

Grape seed extract 2 Publications Verification	Natural Products Classification of Application Fields Vitis vinifera cv. Zalema Metabolic Disease Plants Vitaceae Disease Research Fields Inflammation/Immunology Source Classification	Apoptosis
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells .

HY-126411

Peonidin-3-O-galactoside chloride	Structural Classification Anthocyans Flavonoids other families Classification of Application Fields Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Lipase ATP Synthase
Peonidin-3-O-galactoside chloride is an anthocyanin with antioxidant properties and blood-brain barrier permeability. Peonidin-3-O-galactoside chloride inhibits pancreatic lipase, with an IC₅₀ value of 23.2 μg/mL against porcine pancreatic lipase. Peonidin-3-O-galactoside chloride mediates neuroprotection, regulates glucose metabolism, protects cells from high glucose-induced damage, promotes glucose uptake and increases ATP production. Peonidin-3-O-galactoside (chloride) can be used in the research of obesity and neurodegenerative diseases .

HY-N8599

Cichoriin 2 Publications Verification	Infection Structural Classification Monophenols other families Classification of Application Fields Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Amylases Glycosidase Lipase Dipeptidyl Peptidase p38 MAPK PPAR P2Y Receptor NOD-like Receptor (NLR) SARS-CoV Pyroptosis GLUT Angiotensin-converting Enzyme (ACE) NF-κB
Cichoriin is an orally active coumarin glycoside with broad biological activities. Cichoriin exhibits inhibitory activities against α-amylase, α-glucosidase, **pancreatic lipase and DPP-IV, with IC₅₀ values of 5.76, 2.94, 16.83 and 9.16 μg/mL, respectively. Cichoriin significantly improves metabolic dysfunction-associated steatohepatitis (MASH) in mice by activating the AMPK signaling pathway. Cichoriin upregulates PPAR-γ in adipose tissue and alleviates obesity and associated cardiorenal injury in rats. Cichoriin blocks monosodium urate crystal-induced activation of the NLRP3 inflammasome and cell pyroptosis by inhibiting P2Y₁₄R (IC₅₀** = 8.47 nM). In silico virtual screening reveals that Cichoriin has a strong binding affinity for SARS-CoV-2 .

HY-119741

Salacinol	Structural Classification Natural Products Salacia reticulata Wight Celastraceae Plants Source Classification	Glycosidase Lipase
Salacinol, compound found in Salacia reticulata, is an orally active *α-glucosidase/lipase* inhibitor. Salacinol inhibits enzymatic activity of intestinal maltase (IC₅₀ = 3.2 μg/mL, K_i = 0.31 μg/mL), sucrase (IC₅₀ = 0.84 μg/mL, K_i = 0.32 μg/mL), and isomaltase (IC₅₀ = 0.59 μg/mL, K_i = 0.47 μg/mL), and inhibits increases in serum glucose levels in sucrose-loaded rats. Salacinol also inhibits **pancreatic lipase** and lipoprotein lipase. Salacinol can be used for the research of diabetes mellitus .

HY-N0555

Escin IB	Triterpenes Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Metabolic Disease Plants Disease Research Fields Source Classification	Lipase
Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on **pancreatic lipase** activity .

HY-N4167

3-O-Methylgalangin 1 Publications Verification Galangin 3-methyl ether; 3-Methylgalangin	Infection Flavonols Flavonoids Classification of Application Fields Phenols Polyphenols Alpinia officinarum Hance Plants Disease Research Fields Source Classification Zingiberaceae	Bacterial
3-O-Methylgalangin (Galangin 3-methyl ether) is a natural flavonoid compound from the rhizome of Alpinia officinarum (AO) with antibacterial activities, which also inhibits pancreatic lipase .

HY-N16617

Platycodin V	Triterpenes Structural Classification Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Source Classification	Lipase
Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.

HY-N3797A

Echitamine chloride Ditaine chloride	Apocynaceae Alkaloids Classification of Application Fields Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Cancer Source Classification	Apoptosis
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits **pancreatic lipase with an IC₅₀** of 10.92 μM .

HY-N2330

Lipstatin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Lipase
Lipstatin is a pancreatic lipase inhibitor (IC₅₀=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM) .

HY-N15385

Hericenone D	Structural Classification Monophenols Microorganisms Phenols Source Classification	Lipase
Hericenone D, an orally active **pancreatic lipase** inhibitor, can be found in Hericium erinaceus. Hericenone D reduces lipid absorption and stimulates nerve growth factor NGF gene expression. Hericenone D can be used for the research of menopausal obesity .

HY-N4298

Epitheaflagallin 3-O-gallate	Classification of Application Fields Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Inflammation/Immunology Source Classification Theaceae	MMP
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .

HY-N12292

Acanthopanaxoside A	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Lipase
Acanthopanaxoside A, a triterpenoid saponin, has pancreatic *lipase* inhibitory action .

HY-N12296

Ciwujianoside C4	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Lipase
Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12294

Ciwujianoside D2	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae Source Classification	Lipase
Ciwujianoside D2, a saponin compound, can enhance **pancreatic lipase** activity in vitro .

HY-N12297

Ciwujianoside C2	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Lipase
Ciwujianoside C2 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C2 enhances pancreatic lipase activity in vitro .

HY-N8362

1-Isomangostin	Natural Products Guttiferae Garcinia mangostana Linn. Plants Source Classification	Lipase
1-Isomangostin is an inhibitor of **pancreatic lipase*. 1-Isomangostin inhibits porcine pancreatic* lipase with an IC₅₀ of 34.5 μM. 1-Isomangostin has anti-obesity activity .

HY-N12298

Ciwujianoside C1	Triterpenes Structural Classification Terpenoids Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Pentacyclic Triterpenoids Araliaceae Source Classification	Lipase
Ciwujianoside C1 is a saponin, that can be isolated from the leaves of Acanthopanax senticosus. Ciwujianoside C1 inhibits pancreatic lipase activity in vitro .

HY-N7163

(2S)-5,7,3',5'-Tetrahydroxyflavanone (2S)-3',5,5'7-Tetrahydroxyflavanone	Viguiera dentata (Cav.) Spreng. Structural Classification Flavonoids Labiatae Flavonones Plants Source Classification	Lipase
(2S)-5,7,3',5'-Tetrahydroxyflavanone ((2S)-3',5,5'7-Tetrahydroxyflavanone) is a porcine pancreatic lipase modulator with an IC₅₀ of >200 μM against porcine pancreatic lipase. (2S)-5,7,3',5'-Tetrahydroxyflavanone interacts with an enzyme involved in triglyceride hydrolysis .

HY-N11999

5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl	Orchidaceae Phenols Polyphenols Dendrobium wattii (J. D. Hooker) H. G. Reichenbach Plants Source Classification	Glycosidase
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Rhodiola sacra (Prain ex Raym.-Hamet) S. H. Fu Crassulaceae Phenols Polyphenols Plants Source Classification	Endogenous Metabolite
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a **pancreatic lipase inhibitor, with an IC₅₀** value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-N14641

Panclicin A	Natural Products Microorganisms Source Classification	Lipase
Panclicin A is a potent **pancreatic lipase** inhibitor .

HY-N14643

Panclicin C	Natural Products Microorganisms Source Classification	Lipase
Panclicin C is a potent **pancreatic lipase** inhibitor .

HY-N14647

Panclicin E	Natural Products Microorganisms Source Classification	Lipase
Panclicin E is a potent **pancreatic lipase** inhibitor .

HY-N14646

Panclicin D	Natural Products Microorganisms Source Classification	Lipase
Panclicin D is a potent **pancreatic lipase** inhibitor .

HY-N14642

Panclicin B	Natural Products Microorganisms Source Classification	Lipase
Panclicin B is a potent **pancreatic lipase** inhibitor .

HY-N7668

Neotheaflavin	Flavonoids Classification of Application Fields Flavanols Phenols Polyphenols Metabolic Disease Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Source Classification Theaceae	Lipase
Neotheaflavin, from black tea, inhibits pancreatic lipase .

HY-N17567

Morusalnol A	Structural Classification Monophenols Phenols Plants Moraceae Morus alba Linn. Source Classification	Lipase
Morusalnol A is a arylbenzofuran derivative found in the root bark of Morus alba. Morusalnol A is a **pancreatic lipase** inhibitor with a porcine pancreatic lipase IC₅₀ of 0.71 μM. Morusalnol A inhibits pancreatic lipase activity. Morusalnol A can be used for the research of obesity .

HY-N0555R

Escin IB (Standard)	Triterpenes Structural Classification Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Source Classification	Lipase Reference Standards
Escin IB (Standard) is the analytical standard of Escin IB. This product is intended for research and analytical applications. Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity .

HY-N18145

(3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate	Structural Classification Natural Products Plants Compositae Source Classification Erythrina sigmoidea Hua	Lipase
(3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate is a human pancreatic *lipase* inhibitor, with an IC₅₀ of 77.97 μM against human pancreatic lipase. (3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate is applicable to the research of obesity .

HY-N7988

4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate	Structural Classification Plants Compositae Lipid Source Classification Erythrina sigmoidea Hua	Lipase
4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate is a polyacetylene compound found in the rhizomes of Atractylodes lancea. 4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate inhibits human **pancreatic lipase, with an IC₅₀** of 55.67 μM and 16.7 μg/mL. 4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate can block the digestion of triglycerides by inhibiting the activity of human pancreatic lipase. 4,6,12-Tetradecatriene8,10-diyne-1,3-diacetate can be used in research on obesity .

HY-N17876

Royleanonic acid	Quinones Structural Classification Labiatae Pteris semipinnata L. Sp. Plants Phenanthrenequinones Source Classification	Lipase
Royleanonic acid is an abietan-type diterpene found in the leaves of Salvia officinalis L. Royleanonic acid is a porcine pancreatic lipase inhibitor with an IC₅₀ of 35 μg/mL .

HY-N18267

(3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate	Structural Classification Natural Products Plants Compositae Source Classification Erythrina sigmoidea Hua	Lipase
(3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate is a polyacetylene found in Atractylodes lancea rhizome. (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate inhibits human pancreatic lipase inhibitor with an IC₅₀ of 39.91 μM. (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate can be used for the research of obesity .

HY-N11721

5-Hydroxyaloin A	Structural Classification Liliaceae Aloe microstigma Salm-Dyck Phenols Polyphenols Plants Source Classification	SOD Lipase
5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity .

HY-N14093

Aspulvinone H	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Cholinesterase (ChE) Lipase Reactive Oxygen Species (ROS) Apoptosis Bacterial
Aspulvinone H is an orally active inhibitor of AChE, pancreatic *lipase, glutamic-oxaloacetic transaminase 1, and α-glucosidase, with IC₅₀* values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It has a K_a of 2.14 μM against GOT1 and a K_i of 6.58 μM against α-glucosidase. Aspulvinone H inhibits cancer cell proliferation, interferes with glutamine metabolism, elevates ROS levels, and induces cell apoptosis and S-phase arrest. Aspulvinone H exhibits antibacterial activity against Staphylococcus aureus. Aspulvinone H inhibits the growth of pancreatic ductal adenocarcinoma xenografts. Aspulvinone H reduces postprandial blood glucose in mice. Aspulvinone H can be used in research related to pancreatic ductal adenocarcinoma, diabetes, and Staphylococcus aureus infection .

HY-N17996

3'-O-Methy isosaponarin	Structural Classification Flavonoids Flavones Cucurbitaceae Plants Cucumis sativus L. Source Classification	Lipase
3'-O-Methylisosaponarin is a spsoscoparin glycoside found in the leaves of C. sativus cultivar Chinese Yellow. 3'-O-Methylisosaponarin shows weak anti-lipase activity. 3'-O-Methylisosaponarin can be used for the research of disturbances of lipid metabolism .

HY-N19783

Carambolaside M	Structural Classification Polysaccharides Averrhoa carambola L. Plants Oxalidaceae Saccharides Source Classification	Drug Derivative
Carambolaside M acts as an ABTS radical cation scavenger. Carambolaside M scavenges ABTS radical cations. Carambolaside M is isolated from the fresh sweet fruits of Averrhoa carambola L., a plant belonging to the genus Averrhoa in the Oxalidaceae family .

HY-W719455

Pungenin	Structural Classification Pinaceae Picea obovata Ledeb. Plants Saccharides Monosaccharides Source Classification	Lipase
Pungenin is a compound that can be isolated from Leontopodium leontopodioides. Pungenin exhibits lipase inhibitory activity. Pungenin reuduces triglyceride absorption .

Species:	Human (4) Rat (1) Mouse (1) Dog (1)
Tag:	SUMO (1) His (7)
Source:	HEK293 (4) P. pastoris (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75978

	*PNLIP/Pancreatic* lipase Protein, Human (HEK293, His)** 1 Publications Verification Pnlippancreatic triacylglycerol lipase; PL; PTL; pancreatic lipase	Human	HEK293
	PNLIP/Pancreatic lipase Protein is pivotal in fat metabolism, preferentially cleaving esters of long-chain fatty acids at positions 1 and 3, yielding 2-monoacylglycerol and free fatty acids. It displays increased activity with insoluble emulsified substrates over soluble ones. PNLIP/Pancreatic lipase Protein, Human (HEK293, His) is the recombinant human-derived PNLIP/Pancreatic lipase protein, expressed by HEK293 , with C-His, C-8*His labeled tag.

HY-P71582

	*PNLIP/Pancreatic* lipase Protein, Mouse (His-SUMO)** Pnlippancreatic triacylglycerol lipase; PL; PTL; pancreatic lipase; EC 3.1.1.3	Mouse	E. coli
	Pancreatic lipase (PNLIP) plays a crucial role in fat metabolism by enzymatically breaking down dietary lipids and preferentially selecting long-chain fatty acid esters at positions 1 and 3. This results in the production of mainly 2-monoacylglycerol and free fatty acids. PNLIP/Pancreatic lipase Protein, Mouse (His-SUMO) is the recombinant mouse-derived PNLIP/Pancreatic lipase protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P77149

	PNLIPRP2 Protein, Human (sf9, His) pancreatic lipase-related protein 2; PL-RP2; Galactolipase; PNLIPRP2	Human	Sf9 insect cells
	The PLRP2 protein is a multifunctional lipase that hydrolyzes triglycerides and galactosylglycerides with broad substrate specificity. It is essential for newborns and plays an important role in the pancreas' digestion of dietary fats, especially milk fat globules, which are rich in long-chain triglycerides. PNLIPRP2 Protein, Human (sf9, His) is the recombinant human-derived PLRP2 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P70991

	PLRP1 Protein, Human (HEK293, His) pancreatic lipase-Related Protein 1; PL-RP1; PNLIPRP1; PLRP1	Human	HEK293
	PLRP1 Protein is a protein that encoded by PNLIPRP1 genne. PLRP1 is produced by pancreatic acinar cells and expressed in the pancreas. PLRP1 is involved in lipid catabolic process, acting as a negative regulator of pancreatic lipase activity by competing with pancreatic lipase for colipase occupancy. And it may function as inhibitor of dietary triglyceride digestion. PLRP1 Protein, Human (HEK293, His) is the recombinant human-derived PLRP1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77464

	PNLIPRP1 Protein, Rat (HEK293, His) PNLIPRP1; PLRP1; Inactive pancreatic lipase-related protein 1; PL-RP1	Rat	HEK293
	PNLIPRP1 Protein, a potential inhibitor of dietary triglyceride digestion, likely modulates lipid metabolism. In vitro analyses reveal its lack of detectable lipase activity, suggesting a unique role as an enzyme inhibitor rather than an active participant in triglyceride hydrolysis. This characteristic underscores PNLIPRP1's potential regulatory impact on lipid digestion processes. PNLIPRP1 Protein, Rat (HEK293, His) is the recombinant rat-derived PNLIPRP1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70972

	PNLIPRP2 Protein, Human (HEK293, His) pancreatic lipase-Related Protein 2; PL-RP2; Galactolipase; PNLIPRP2; PLRP2	Human	HEK293
	PNLIPRP2 Protein, Human (HEK293, His) is the recombinant human-derived PNLIPRP2 protein, expressed by HEK293, with C-6*His labeled tag.

HY-P71770

	PNLIPRP1 Protein, Dog (P.pastoris, His) PNLIPRP1; PLRP1; Inactive pancreatic lipase-related protein 1; PL-RP1	Dog	P. pastoris
	The PNLIPRP1 protein acts as an inhibitor of dietary triglyceride digestion and lacks lipase activity on various substrates. This regulatory effect suggests an effect on the breakdown of dietary triglycerides. PNLIPRP1 Protein, Dog (P.pastoris, His) is the recombinant dog-derived PNLIPRP1 protein, expressed by P. pastoris , with N-His labeled tag.

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HY-B0218S

Orlistat-d3
Orlistat-d3 is a deuterated labeled Orlistat . Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric *lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN*), is used orally for long-term research of obesity .?Anti-atherosclerotic?effect .

Host:	Rabbit (3)
Reactivity:	Human (3)
Application:	IHC-P (3) IF-Tissue (1) IHC-F (1) WB (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (1) Recombinant (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81503

	Pancreatic Lipase Antibody (YA1248) pancreatic lipase; PL; PNLIP; PNLIPD; PTL	IHC-P	Human
	Pancreatic Lipase Antibody (YA1248) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pancreatic Lipase.

HY-P81503A

	Pancreatic Lipase Antibody (YA1248)(PBS only) pancreatic lipase; PL; PNLIP; PNLIPD; PTL	IHC-P	Human
	Pancreatic Lipase Antibody (YA1248) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pancreatic Lipase.

HY-P87976

	Pancreatic Lipase Antibody (YA7661)	WB, IHC-P, IHC-F, IF-Tissue	Human
	Pancreatic Lipase Antibody (YA7661) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Pancreatic Lipase.

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HY-B1393

Dehydrocholic acid Dehydrocholate		Cholesterol
Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and *lipase* levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice .

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