145-41-5
145-41-5
Chemical Structure
Dehydrocholic acid sodium
Synonym(s): Dehydrocholate sodium
- CAS No.: 145-41-5
- Formula:C24H33NaO5
- Molecular Weight:424.51
IUPAC Name: sodium (R)-4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7,12-trioxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
InChIKey: FKJIJBSJQSMPTI-CAOXKPNISA-M
SMILES: C[C@H](CCC(O[Na])=O)[C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])C(C[C@]4([H])CC(CC[C@]4(C)[C@@]3([H])CC2=O)=O)=O
Biological Activity: Dehydrocholic acid (Dehydrocholate) sodium is an orally active hydrocholeretic agent. Dehydrocholic acid sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Dehydrocholic acid sodium | 99.64% | Dehydrocholic acid (Dehydrocholate) sodium is an orally active hydrocholeretic agent. Dehydrocholic acid sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice. | ||||||||||||||||||||
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3-Oxo-5β-cholanoic acid (Standard) | ≥98% | 3-Oxo-5β-cholanoic acid (Standard) is the analytical standard of 3-Oxo-5β-cholanoic acid. This product is intended for research and analytical applications. 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM). | ||||||||||||||||||||
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12-Ketodeoxycholic acid (Standard) | 99.91% | 12-Ketodeoxycholic acid (Standard) is the analytical standard of 12-Ketodeoxycholic acid. This product is intended for research and analytical applications. 12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury | ||||||||||||||||||||
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(5α)-3,6-Dioxocholan-24-oic acid | 99.1% | (5α)-3,6-Dioxocholan-24-oic acid is a secondary bile acid. | ||||||||||||||||||||
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5β-Cholanic acid-3,6-dione | 5β-Cholanic acid-3,6-dione (3,6-Diketo-LCA) is a similar substance to Lithocholic acid (LCA) (HY-B0172). 5β-Cholanic acid-3,6-dione cannot activate the Vitamin D receptor (VDR), and can be used as a negative control for studying the relationship between LCA derivatives and VDR. | |||||||||||||||||||||
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7,12-Diketolithocholic acid | 99.93% | 7,12-Diketolithocholic acid (7,12-Diketo-LCA) is a bile acid, which can be produced in the host-gut microbial co-metabolism of the bile acid pool. | ||||||||||||||||||||
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Dehydrocholic acid | 99.92% | Dehydrocholic acid (Dehydrocholate) is an orally active hydrocholeretic agent. Dehydrocholic acid modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholic acid has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholic acid can be used in the study of acute biliary pancreatitis and obstructive jaundice. | ||||||||||||||||||||
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5β-Cholanic acid 3,7-dione methyl ester | 5β-Cholanic acid 3,7-dione methyl ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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12-Ketochenodeoxycholic acid (Standard) | ≥98% | 12-Ketochenodeoxycholic acid (Standard) is an analytical standard of 12-Ketochenodeoxycholic acid (HY-W403933). This product is intended for research and analytical applications. 12-Ketochenodeoxycholic acid is an anomalous bile acid and Chenodeoxycholic acid (HY-76847) precursor. 12-Ketochenodeoxycholic acid can be used for the research of hepatobiliary diseases. | ||||||||||||||||||||
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Dehydrochenodeoxycholic acid | 99.97% | Dehydrochenodeoxycholic acid is a ketone bile acid. | ||||||||||||||||||||
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(5β)-3,12-Dioxocholan-24-oic acid | (5β)-3,12-Dioxocholan-24-oic acid is a natural product that can be found in animal bile. | |||||||||||||||||||||
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References
- [1]. Zhang X, et al. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice. Biol Pharm Bull. 2020;43(6):985-993. [Content Brief]
- [2]. Yousef IM, et al. Influence of dehydrocholic acid on the secretion of bile acids and biliary lipids in rats. Digestion. 1990;45(1):40-51. [Content Brief]
- [3]. Ratan J, et al. A controlled trial of choleretic and hepatoprotective actions of Livzon and dehydrocholic acid in a model of obstructive jaundice in albino rats. Tohoku J Exp Med. 1997 Jan;181(1):161-6. [Content Brief]
- [4]. UCHIDA K, et al. EFFECTS OF SODIUM URSODEOXYCHOLATE, HYODEOXY-CHOLATE AND DEHYDROCHOLATE ON CHOLESTEROL AND BILE ACID METABOLISM IN RATS. Journal of Pharmacobio-Dynamics, 1983, 6(5): 346-357.
- [5]. Magos L, et al. The effect of phenobarbital and sodium dehydrocholate on the biliary excretion of methylmercury in the rat. Toxicology and Applied Pharmacology, 1974, 30(1): 1-6.
