Dehydrochenodeoxycholic acid (Synonyms: 5β-Cholanic acid-3,7-dione; 3,7-Dioxo-5β-cholanoic acid; 3,7-Diketochenodeoxycholic acid)

Cat. No.: HY-W747313 Purity: 99.97%: Data Sheet
COA

SDS
Handling Instructions
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Dehydrochenodeoxycholic acid is a ketone bile acid.

For research use only. We do not sell to patients.

Dehydrochenodeoxycholic acid Chemical Structure

CAS No. : 859-97-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Dehydrochenodeoxycholic acid is a ketone bile acid^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	10.93 μM Compound: 29	Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay	[PMID: 25735208]

Molecular Weight

388.54

Formula

C₂₄H₃₆O₄

CAS No.

859-97-2

Appearance

Solid

Color

White to off-white

SMILES

O=C1C[C@@]([H])(CC([C@@]2([C@@]3(CC[C@]4([C@]2(CC[C@@]4([C@@H](CCC(O)=O)C)[H])[H])C)[H])[H])=O)[C@]3(C)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (257.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5737 mL	12.8687 mL	25.7374 mL
5 mM	0.5147 mL	2.5737 mL	5.1475 mL
10 mM	0.2574 mL	1.2869 mL	2.5737 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (269 KB) SDS (254 KB)

COA (250 KB) HNMR (248 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. USUI T. THIN-LAYER CHROMATOGRAPHY OF BILE ACIDS WITH SPECIAL REFERENCE TO SEPARATION OF KETO BILE ACIDS. J Biochem. 1963 Sep;54:283-6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5737 mL	12.8687 mL	25.7374 mL	64.3434 mL
	5 mM	0.5147 mL	2.5737 mL	5.1475 mL	12.8687 mL
	10 mM	0.2574 mL	1.2869 mL	2.5737 mL	6.4343 mL
	15 mM	0.1716 mL	0.8579 mL	1.7158 mL	4.2896 mL
	20 mM	0.1287 mL	0.6434 mL	1.2869 mL	3.2172 mL
	25 mM	0.1029 mL	0.5147 mL	1.0295 mL	2.5737 mL
	30 mM	0.0858 mL	0.4290 mL	0.8579 mL	2.1448 mL
	40 mM	0.0643 mL	0.3217 mL	0.6434 mL	1.6086 mL
	50 mM	0.0515 mL	0.2574 mL	0.5147 mL	1.2869 mL
	60 mM	0.0429 mL	0.2145 mL	0.4290 mL	1.0724 mL
	80 mM	0.0322 mL	0.1609 mL	0.3217 mL	0.8043 mL
	100 mM	0.0257 mL	0.1287 mL	0.2574 mL	0.6434 mL

Dehydrochenodeoxycholic acid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dehydrochenodeoxycholic acid859-97-25β-Cholanic acid-3,7-dione 3,7-Dioxo-5β-cholanoic acid 3,7-Diketochenodeoxycholic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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Dehydrochenodeoxycholic acid (Synonyms: 5β-Cholanic acid-3,7-dione; 3,7-Dioxo-5β-cholanoic acid; 3,7-Diketochenodeoxycholic acid)

Dehydrochenodeoxycholic acid Related Antibodies

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Biological Activity

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References

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