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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
pheochromocytoma cells
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "pheochromocytoma cells" in MCE Product Catalog:
1
Category:
Human Gut Microbiota Metabolites Natural Products Other Diseases Endogenous metabolite Disease Research Fields
Target:
1
1 Cited Publications
Synonyms: SR57746A; SR57746 hydrochloride
Target:
5-HT Receptor Dopamine Receptor Trk Receptor PKC ERK Akt JNK
Research Areas:
Xaliproden (SR57746) hydrochloride (SR57746A) is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden hydrochloride activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden hydrochloride also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [ 35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden hydrochloride exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden hydrochloride also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden hydrochloride can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety .
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Toloxatone (MD 69276) is a reversible, selective MAO-A inhibitor that can cross the blood-brain barrier. Toloxatone increases the levels of serotonin (5-HT) and norepinephrine in the brain. Toloxatone reduces the immobility time in the forced swimming test in mice, inhibits killing behavior in rats without causing sedation, and shows a correlation between its free plasma concentration and cerebrospinal fluid concentration. Toloxatone is widely used in research related to depression, depressive disorders and Parkinson's disease .
Cat. No.: HY-P1831
CAS No.: 150238-87-2
Synonyms: ProAM N20, Human; PAMP-20, human
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Cat. No.: HY-117517
CAS No.: 141731-76-2
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Cat. No.: HY-133101
CAS No.: 1031727-34-0
Synonyms: 14-Norpseurotin
Category:
Cat. No.: HY-W277951
CAS No.: 480-93-3
Research Areas:
3-Hydroxyindole is a hydroxyindole compound. 3-Hydroxyindole can be isolated from the fruits of Aristotelia chilensis. 3-Hydroxyindole inhibits Ferroptosis and scavenges DPPH free radicals. 3-Hydroxyindole protects against β-amyloid-induced toxicity. 3-Hydroxyindole exhibits antioxidant activity. 3-Hydroxyindole can be used in research related to neurodegenerative diseases .
Cat. No.: HY-P11313
Synonyms: Rat chromogranin A367–387
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Cat. No.: HY-P5876
CAS No.: 154095-31-5
Synonyms: ProADM N20(bovine, porcine); PAMP-20(bovine, porcine)
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Cat. No.: HY-N14417
CAS No.: 253450-08-7
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Cat. No.: HY-N14424
CAS No.: 334831-87-7
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Cat. No.: HY-123357
CAS No.: 1456807-80-9
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Research Areas:
IMM-H004, a coumarin derivative, possesses neuroprotective and potent free radical scavenging abilities. IMM-H004 significantly inhibits amyloid-β (Aβ)-induced cytotoxicity and apoptosis, offering potential value for research into neurodegenerative diseases such as Alzheimer's disease. Additionally, IMM-H004 is also capable of effectively blocking the calcium mobilization and chemotaxis induced by CKLF1-C27 (HY-P3418), thereby alleviating asthmatic pathological changes in the lung tissue of CKLF1 transgenic mice .
Cat. No.: HY-N17920
CAS No.: 135383-98-1
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Cat. No.: HY-P11753A
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Cat. No.: HY-P11753
CAS No.: 1187540-64-2
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Cat. No.: HY-182401
CAS No.: 160753-58-2
Research Areas:
NS-417 free base is an ERK1, ERK2, and Akt kinase activator with neuroprotective, neurite outgrowth potentiating, and dopaminergic cell population enhancing activity. NS-417 free base enhances activation of ERK1, ERK2, and Akt kinase via growth factor stimulation. NS-417 free base rescues cells from growth factor withdrawal-induced death, stimulates neurite outgrowth, increases tyrosine hydroxylase-positive cell counts, and displays neurotrophic-like activity in in vitro models. NS-417 free base can be used for the research of parkinson’s disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
