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Results for "

phosphonate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Amyloid-β (2) Antibiotic (2) Apoptosis (1) Aquaporin (1) ATP Synthase (1) Bacterial (2) Biochemical Assay Reagents (7) CMV (1) Dipeptidyl Peptidase (2) DNA/RNA Synthesis (4) Drug Derivative (2) Drug Intermediate (8) Endogenous Metabolite (1) Enolase (2) Environmental Pollutants (1) Guanylate Cyclase (1) HBV (1) Insecticide (1) Isotope-Labeled Compounds (6) LPL Receptor (2) LYTACs (1) Mitochondrial Metabolism (2) MOFs (1) Nucleoside Antimetabolite/Analog (2) Parasite (2) Phosphodiesterase (PDE) (1) Phosphoramidites (3) PROTAC Linkers (6) Reactive Oxygen Species (ROS) (2) Reference Standards (4) SARS-CoV (1) SphK (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (8) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Cytosine (1) Uracil (1) Phosphoramidites (3) Guanine (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12688A

*Succinyl phosphonate* trisodium salt** 10+ Cited Publications	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β	Neurological Disease Inflammation/Immunology
Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .

HY-117778

SF2312	Enolase Bacterial Antibiotic	Infection Cancer
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-115460

AER-271 1 Publications Verification	Aquaporin	Cardiovascular Disease Neurological Disease
AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke .

HY-76459

Diethyl (cyanomethyl)phosphonate	Biochemical Assay Reagents Drug Intermediate	Others
Diethyl (cyanomethyl)phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diethyl (cyanomethyl)phosphonate is also an important intermediate and can be used in the synthesis of other active compounds .

HY-W035361

(Aminomethyl)phosphonic acid	Environmental Pollutants Biochemical Assay Reagents	Others
(Aminomethyl)phosphonic acid is used as a phosphonate agent in wastewater treatment .

HY-12688

Succinyl phosphonate	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β	Neurological Disease Inflammation/Immunology
Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .

HY-W570890

2'-O-MOE-5-Me-C(Bz)	Phosphoramidites DNA/RNA Synthesis	Others
2'-O-MOE-5-Me-C(Bz) is a nucleotide analog that can be used for the synthesis of oligonucleotides.

HY-Y0677

Triethyl phosphonoacetate	Biochemical Assay Reagents	Others
Carbethoxymethyldiethyl phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W006103

I-bu-rG Phosphoramidite	Phosphoramidites Drug Intermediate	Others
I-bu-rG Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of nucleotides and nucleic acids .

HY-117778B

SF2312 ammonium	Enolase Bacterial Antibiotic ATP Synthase	Infection Cancer
SF2312 ammonium is a phosphonate Antibiotic and Enolase inhibitor, with an IC₅₀ of 18.4 nM against E. coli enolase. SF2312 ammonium reduces intracellular ATP levels and inhibits glycolytic flux. SF2312 ammonium exhibits activity against both Gram-positive and Gram-negative bacteria, and exerts synergistic effects against E. coli when combined with Fosfomycin (HY-B1075A). SF2312 ammonium shows selective toxicity toward gliomas with ENO1 gene knockout. SF2312 ammonium can be used in research related to bacterial infections and gliomas .

HY-Y0677S

*Carbethoxymethyldiethyl phosphonate-C13*	Isotope-Labeled Compounds	Others
Carbethoxymethyldiethyl phosphonate- ¹³C₂ is the C13 labeled Carbethoxymethyldiethyl phosphonate .

HY-140324

*Tetraethyl octane-1,8-diylbis(phosphonate)*	PROTAC Linkers	Cancer
Tetraethyl octane-1,8-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-113586

Besifovir Dipivoxil LB-80380	HBV DNA/RNA Synthesis Drug Derivative	Infection
Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B .

HY-W587529

2-Chloroethyl (2-chloroethyl)phosphonate	Drug Intermediate	Others
2-Chloroethyl (2-chloroethyl)phosphonate is an Organophosphorus compound and can be used as an intermediate in organic synthesis.

HY-22038

Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate	Drug Intermediate	Others
Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate is a drug intermediate for synthesis of various active compounds.

HY-W087962

Phenylphosphonic acid	Insecticide	Others
Phenylphosphonic acid (Compound 1) is a synthetic pyrethroid insecticide that can effectively control some underground pests. Phenylphosphonic acid also can be a ligand in some metal-catalyzed reactions, which is promising for research of metal phosphonates comprising layered structures and pesticides .

HY-15382A

(S)-FTY720-phosphonate	LPL Receptor	Inflammation/Immunology
FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

HY-132238

Tetradecylphosphonic acid TDPA; Tetradecyl phosphonate	Biochemical Assay Reagents	Others
Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-101605

Prodipine hydrochloride	Dipeptidyl Peptidase	Cardiovascular Disease
Prodipine, a diphenyl-phosphonate derivative. The IC₅₀s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.

HY-112485

(R)-FTY720-vinylphosphonate	SphK Drug Derivative	Cancer
(R)-FTY720-vinylphosphonate is a sphingosine kinase 1 (SK1) inhibitor. (R)-FTY720-ene-phosphonate is also an FTY720 analogue. (R)-FTY720-vinylphosphonate is promising for research of solid tumors like breast cancer .

HY-W010354

2,2-Diethoxyethanol	Drug Intermediate	Infection
2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection .

HY-176001

DPP8/9-IN-1	Dipeptidyl Peptidase	Inflammation/Immunology Cancer
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidases 8 and 9 (DPP8/9) with IC₅₀ values of 14 and 298 nM, respectively. DPP8/9-IN-1 binds irreversibly to the active site serine (S730 in DPP9) via a phosphonate warhead and blocks substrate binding to inhibit DPP8/9-mediated protein processing. DPP8/9-IN-1 is promising for research of cancers and inflammatory diseases .

HY-W393115

Diethyl (6-bromohexyl)phosphonate	Biochemical Assay Reagents	Others
Diethyl 6-bromohexylphosphonate is a short linker featuring a bromide and a diethyl phosphonate. The bromide is a good leaving group which can be easily displaced by nucleophiles like alcohols, amines or thiols, while the diethyl phosphonate may be hydrolyzed to allow for esterification.

HY-W701567

Dimethyl (S)-(4-(methyl-d3)-2-oxooctyl)phosphonate	Isotope-Labeled Compounds	Others
Dimethyl (S)-(4-(methyl-d₃)-2-oxooctyl)phosphonate is the deuterium labeled Dimethyl (S)-(4-(methyl)-2-oxooctyl)phosphonate.

HY-141296

*PEG5-bis-(Ethyl phosphonate)*	PROTAC Linkers	Cancer
PEG5-bis-(Ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141295

*PEG3-bis-(ethyl phosphonate)*	PROTAC Linkers	Cancer
PEG3-bis-(ethyl phosphonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140003

*Tetraethyl butane-1,4-diylbis(phosphonate)*	PROTAC Linkers	Cancer
Tetraethyl butane-1,4-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140323

*Tetraethyl heptane-1,7-diylbis(phosphonate)*	PROTAC Linkers	Cancer
Tetraethyl heptane-1,7-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140325

*Tetraethyl decane-1,10-diylbis(phosphonate)*	PROTAC Linkers	Cancer
Tetraethyl decane-1,10-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W747167

[(R)-2-(Phenylphosphonomethoxy)propyl]adenine-d5 Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate-d₅	Isotope-Labeled Compounds	Others
[(R)-2-(Phenylphosphonomethoxy)propyl]adenine-d₅ (Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate-d₅) is the deuterium labeled Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate (HY-W004381).

HY-144294

Purine phosphoribosyltransferase-IN-1	Parasite	Infection
Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with K_i values of 50, 20, and 2 nM, respectively .

HY-W739906

Adefovir Diethyl Ester-d4	Isotope-Labeled Compounds	Others
Adefovir Diethyl Ester-d₄ is the deuterium labeled Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate (HY-W330007).

HY-162912

Enpp-1-IN-23	Phosphodiesterase (PDE)	Cancer
Enpp-1-IN-23 (compound 27) is an Enpp-1 inhibitor, with IC₅₀ of 1.2 nM. Enpp-1-IN-23 can be used in cancer research .

HY-155056

SARS-CoV-2 Mpro-IN-7	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-7 (compound 6g) is a potent inhibitor of M ^pro-SARS-CoV-2 (IC₅₀=8.8 μM, CC₅₀=10 μM) .

HY-170956

BTN3A1 ligand-1	Drug Intermediate	Inflammation/Immunology
BTN3A1 ligand-1 (Compound 26b) is a triazole-containing aryl/acyloxyalkyl phosphonate prodrug. BTN3A1 ligand-1 can stimulate T cell proliferation (EC₅₀ : 0.49 nM) and interferon γ secretion. BTN3A1 ligand-1 has certain plasma stability and can be used in related immunotherapy research .

HY-W011177R

*Tetraisopropyl methylenebis(phosphonate) (Standard)* Tetrapropan-2-yl methanediylbis(phosphonate) (Standard)	Reference Standards
Tetraisopropyl methylenebis(phosphonate) (Standard) is the analytical standard of Tetraisopropyl methylenebis(phosphonate). This product is intended for research and analytical applications.

HY-164396

Allyl-mannose-6-phosphonate	Drug Intermediate LYTACs	Cancer
Allyl-mannose-6-phosphonate (M6Pn; Compound 6) is a stable analogue of mannose-6-phosphate (M6P). Allyl-mannose-6-phosphonate can be used to synthesize M6Pn-peptide conjugates and construct lysosome-targeting chimeras (LYTAC) .

HY-W793743S

*Dimethyl (2-oxononyl)phosphonate-d15*	Isotope-Labeled Compounds	Others
Dimethyl (2-oxononyl)phosphonate-d₁₅ is the deuterium labeled Dimethyl (2-oxononyl)phosphonate (HY-W793743).

HY-203833

*5'-POM-(E)-Vinyl phosphonate-2'-MOE-U-3'-CE phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
5'-POM-(E)-vinyl phosphonate-2'-MOE-U-3'-CEPhosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-W308027

(2-Amino-1-hydroxyethyl)phosphonate 1-Hydroxy-2-aminoethylphosphonic acid	Nucleoside Antimetabolite/Analog	Metabolic Disease
(2-Amino-1-hydroxyethyl)phosphonate (1-Hydroxy-2-aminoethylphosphonic acid) is a nucleoside metabolite.

HY-W034555

Diethyl [2,2':6',2''-terpyridin]-4'-ylphosphonate Diethyl 2,2':6',2''-terpyridine-4'-phosphonate	MOFs	Others
Diethyl [2,2':6',2''-terpyridin]-4'-ylphosphonate (Diethyl 2,2':6',2''-terpyridine-4'-phosphonate) is a metal-organic framework (MOF).

HY-W004381R

*Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate* (Standard)**	Reference Standards
Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate (Standard) is the analytical standard of Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate. This product is intended for research and analytical applications.

HY-Y0677R

Triethyl phosphonoacetate (Standard)	Biochemical Assay Reagents Reference Standards	Others
Triethyl phosphonoacetate (Standard) is the analytical standard of Triethyl phosphonoacetate. This product is intended for research and analytical applications. Carbethoxymethyldiethyl phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W035361S1

(Aminomethyl)phosphonic acid-13C,15N,d2	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
(Aminomethyl)phosphonic acid- ¹³C, ¹⁵N,d₂ is the ¹³C-, ¹⁵N- and deuterium labeled (Aminomethyl)phosphonic acid (HY-W035361). (Aminomethyl)phosphonic acid is used as a phosphonate agent in wastewater treatment .

HY-179656

UA2239	Parasite Guanylate Cyclase Nucleoside Antimetabolite/Analog	Infection
UA2239 is an antimalarial agent and acyclic nucleoside phosphonate. UA2239 disrupts the essential cGMP-dependent egress pathway by decreasing cGMP levels. UA2239 targets guanylyl cyclase α. UA2239 demonstrates rapid and irreversible inhibitory effects on Plasmodium parasites .

HY-147063R

N-Acetyl-α-D-glucosamine 1-phosphate disodium (Standard)	Reference Standards Endogenous Metabolite	Others
Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .

HY-182962

7-Methylguanosine 5-disphosphoimidazolide disodium 7-Me-3'-OMe-GDP imidazole	Amino Acid Derivatives Drug Intermediate	Others
7-Methylguanosine 5-disphosphoimidazolide disodium (7-Me-3'-OMe-GDP imidazole) is a guanosine diphosphate imidazolide and starting material for synthesis of alkyne-containing C-phosphonate and phosphoester clickable mononucleotide building blocks for triazole-modified mRNA cap analogues .

HY-12898

(S)-FTY-720 Vinylphosphonate	LPL Receptor Apoptosis	Inflammation/Immunology
(S)-FTY-720 Vinylphosphonate is a chiral phosphonate analogue of Fingolimod (HY-11063). (S)-FTY-720 Vinylphosphonate can activate the S1P₁ receptor with an EC₅₀ value of 75 nM. (S)-FTY-720 Vinylphosphonate can significantly inhibit Camptothecin (HY-16560)-induced apoptosis in IEC-6 cells. (S)-FTY-720 Vinylphosphonate is applicable for the research of autoimmune diseases .

HY-185150

PMEG 9-(2-Phosphonylmethoxy)ethylguanine	DNA/RNA Synthesis CMV	Infection Inflammation/Immunology Cancer
PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma ^[1][2].

Cat. No.	Product Name	Type

HY-76459

Diethyl (cyanomethyl)phosphonate	Biochemical Assay Reagents
Diethyl (cyanomethyl)phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diethyl (cyanomethyl)phosphonate is also an important intermediate and can be used in the synthesis of other active compounds .

HY-W035361

(Aminomethyl)phosphonic acid	Biochemical Assay Reagents
(Aminomethyl)phosphonic acid is used as a phosphonate agent in wastewater treatment .

HY-Y0677

Triethyl phosphonoacetate	Biochemical Assay Reagents
Carbethoxymethyldiethyl phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W006103

I-bu-rG Phosphoramidite	Biochemical Assay Reagents
I-bu-rG Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of nucleotides and nucleic acids .

HY-Y0677R

Triethyl phosphonoacetate (Standard)	Biochemical Assay Reagents
Triethyl phosphonoacetate (Standard) is the analytical standard of Triethyl phosphonoacetate. This product is intended for research and analytical applications. Carbethoxymethyldiethyl phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12688A

*Succinyl phosphonate* trisodium salt** 10+ Cited Publications	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification Cancer	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β
Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .

HY-117778

SF2312	Natural Products Microorganisms Source Classification	Enolase Bacterial Antibiotic
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC₅₀s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .

HY-12688

Succinyl phosphonate	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β
Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .

HY-W087962

Phenylphosphonic acid	Microorganisms Source Classification	Insecticide
Phenylphosphonic acid (Compound 1) is a synthetic pyrethroid insecticide that can effectively control some underground pests. Phenylphosphonic acid also can be a ligand in some metal-catalyzed reactions, which is promising for research of metal phosphonates comprising layered structures and pesticides .

HY-W010354

2,2-Diethoxyethanol	Structural Classification Natural Products Cestrum nocturnum Linn. Solanaceae Plants Source Classification	Drug Intermediate
2,2-Diethoxyethanol is a drug intermediate used in research related to Plasmodium falciparum infection .

HY-W308027

(2-Amino-1-hydroxyethyl)phosphonate 1-Hydroxy-2-aminoethylphosphonic acid	Structural Classification Natural Products Amino acids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
(2-Amino-1-hydroxyethyl)phosphonate (1-Hydroxy-2-aminoethylphosphonic acid) is a nucleoside metabolite.

HY-147063R

N-Acetyl-α-D-glucosamine 1-phosphate disodium (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Indole (Standard) is the analytical standard of Indole. This product is intended for research and analytical applications. Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .

Cat. No.	Product Name	Chemical Structure

HY-Y0677S

*Carbethoxymethyldiethyl phosphonate-C13*
Carbethoxymethyldiethyl phosphonate- ¹³C₂ is the C13 labeled Carbethoxymethyldiethyl phosphonate .

HY-W701567

Dimethyl (S)-(4-(methyl-d3)-2-oxooctyl)phosphonate
Dimethyl (S)-(4-(methyl-d₃)-2-oxooctyl)phosphonate is the deuterium labeled Dimethyl (S)-(4-(methyl)-2-oxooctyl)phosphonate.

HY-W747167

[(R)-2-(Phenylphosphonomethoxy)propyl]adenine-d5
[(R)-2-(Phenylphosphonomethoxy)propyl]adenine-d₅ (Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate-d₅) is the deuterium labeled Phenyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate (HY-W004381).

HY-W739906

Adefovir Diethyl Ester-d4
Adefovir Diethyl Ester-d₄ is the deuterium labeled Diethyl ((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonate (HY-W330007).

HY-W793743S

*Dimethyl (2-oxononyl)phosphonate-d15*
Dimethyl (2-oxononyl)phosphonate-d₁₅ is the deuterium labeled Dimethyl (2-oxononyl)phosphonate (HY-W793743).

HY-W035361S1

(Aminomethyl)phosphonic acid-13C,15N,d2
(Aminomethyl)phosphonic acid- ¹³C, ¹⁵N,d₂ is the ¹³C-, ¹⁵N- and deuterium labeled (Aminomethyl)phosphonic acid (HY-W035361). (Aminomethyl)phosphonic acid is used as a phosphonate agent in wastewater treatment .

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