50 Results for "

phosphonate

" in MedChemExpress (MCE) Product Catalog:
Products (50)

50 Results for "phosphonate" in MCE Product Catalog:

14
14 Publications Verification
Cat. No.: HY-12688A
CAS No.: 864167-45-3
Purity:  ≥98.0%
Succinyl phosphonate trisodium salt is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate trisodium salt protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate trisodium salt corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate trisodium salt reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate trisodium salt improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate trisodium salt can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .
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1
1 Cited Publications
Cat. No.: HY-115460
CAS No.: 634913-39-6
Purity:  98.00%
Target:  

Aquaporin

AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke .
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Cat. No.: HY-117778
CAS No.: 107729-45-3
Purity:  ≥95.0%
SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions .
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Cat. No.: HY-76459
CAS No.: 2537-48-6
Diethyl (cyanomethyl)phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Diethyl (cyanomethyl)phosphonate is also an important intermediate and can be used in the synthesis of other active compounds .
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Cat. No.: HY-W035361
CAS No.: 1066-51-9
(Aminomethyl)phosphonic acid is used as a phosphonate agent in wastewater treatment .
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Cat. No.: HY-12688
CAS No.: 26647-82-5
Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .
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Cat. No.: HY-W570890
CAS No.: 163759-94-2
Research Areas:  

Others

2'-O-MOE-5-Me-C(Bz) is a nucleotide analog that can be used for the synthesis of oligonucleotides.
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Cat. No.: HY-Y0677
CAS No.: 867-13-0
Carbethoxymethyldiethyl phosphonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No.: HY-W006103
CAS No.: 147201-04-5
I-bu-rG Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of nucleotides and nucleic acids .
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Cat. No.: HY-Y0643
CAS No.: 18997-19-8
Pivaloyloxymethyl chloride is an organic intermediate used to introduce the pivaloyloxymethyl (POM) protecting group, and it can be prepared from trimethylacetic acid and chloromethyl chlorosulfonate as raw materials. Pivaloyloxymethyl chloride is an alkylating reagent for the synthesis of phosphonic acid prodrugs; the introduction of the hydrophobic POM group enhances the lipid solubility and membrane permeability of molecules. Pivaloyloxymethyl chloride can be used in the synthesis of tetrakis (pivaloyloxymethyl) methylenebisphosphonate, which is a precursor of the pivaloyloxymethyl clodronate prodrug. Pivaloyloxymethyl chloridecan support the synthesis of aryl/pivaloyloxymethyl mixed phosphonate prodrugs of butyrophilin 3A1 ligands .
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Cat. No.: HY-117778B
Purity:  ≥98.0%
Research Areas:  

Infection Cancer

SF2312 ammonium is a phosphonate Antibiotic and Enolase inhibitor, with an IC50 of 18.4 nM against E. coli enolase. SF2312 ammonium reduces intracellular ATP levels and inhibits glycolytic flux. SF2312 ammonium exhibits activity against both Gram-positive and Gram-negative bacteria, and exerts synergistic effects against E. coli when combined with Fosfomycin (HY-B1075A). SF2312 ammonium shows selective toxicity toward gliomas with ENO1 gene knockout. SF2312 ammonium can be used in research related to bacterial infections and gliomas .
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Cat. No.: HY-Y0677S
CAS No.: 100940-60-1
Carbethoxymethyldiethyl phosphonate- 13C2 is the C13 labeled Carbethoxymethyldiethyl phosphonate .
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Cat. No.: HY-140324
CAS No.: 5943-61-3
Target:  

PROTAC Linkers

Research Areas:  

Cancer

Tetraethyl octane-1,8-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
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Cat. No.: HY-113586
CAS No.: 441785-26-8
Synonyms: LB-80380
Research Areas:  

Infection

Besifovir Dipivoxil (LB-80380), an analog of guanosine monophosphate, is an acyclic nucleotide phosphonate with antiviral effect. Besifovir Dipivoxil is rapidly converted by the liver and intestine to the intermediate metabolite LB80331 via the esterification process, subsequently phosphorylated into the di- and triphosphate forms, which act as antiviral DNA synthesis inhibitors. Besifovir Dipivoxil is promising for research of chronic hepatitis B .
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Cat. No.: HY-W587529
CAS No.: 17378-30-2
Target:  

Drug Intermediate

Research Areas:  

Others

2-Chloroethyl (2-chloroethyl)phosphonate is an Organophosphorus compound and can be used as an intermediate in organic synthesis.
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Cat. No.: HY-22038
CAS No.: 50889-46-8
Target:  

Drug Intermediate

Research Areas:  

Others

Dimethyl (3,3-difluoro-2-oxoheptyl)phosphonate is a drug intermediate for synthesis of various active compounds.
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Cat. No.: HY-W087962
CAS No.: 1571-33-1
Category:  

Microorganisms

Target:  

Insecticide

Phenylphosphonic acid (Compound 1) is a synthetic pyrethroid insecticide that can effectively control some underground pests. Phenylphosphonic acid also can be a ligand in some metal-catalyzed reactions, which is promising for research of metal phosphonates comprising layered structures and pesticides .
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Cat. No.: HY-15382A
CAS No.: 1142015-10-8
Purity:  99.91%
Target:  

LPL Receptor

Research Areas:  

Inflammation/Immunology

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
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Cat. No.: HY-132238
CAS No.: 4671-75-4
Synonyms: TDPA; Tetradecyl phosphonate
Research Areas:  

Others

Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No.: HY-101605
CAS No.: 31314-39-3
Purity:  99.84%
Target:  

Dipeptidyl Peptidase

Research Areas:  

Cardiovascular Disease

Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.
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