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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
258 Results for "
probe compounds
" in MedChemExpress (MCE) Product Catalog:
Products (258)
258 Results for "probe compounds" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: CMFDA
3
3 Cited Publications
Cat. No.: HY-16100
CAS No.: 1291779-76-4
Target:
Research Areas:
BI 99179, a chemical probe, is a potent and selective type I fatty acid synthase (FAS) inhibitor with an IC50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats .
3
3 Cited Publications
Cat. No.: HY-18664
CAS No.: 900305-37-5
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Research Areas:
PFI-4 (compound 11), a chemical probe, is a potent and highly selective BRPF1 Bromodomain (BRPF1B) inhibitor, with an IC50 of 172 nM. PFI-4 can be used to explore the functional mechanisms of the HBO1/BRPF1 complex and to study bone loss and osteolytic malignant bone lesions .
3
3 Cited Publications
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Research Areas:
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
2
2 Cited Publications
Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, extracted from patent WO2014059368A1 Compound 1-5, has an IC50 of 0.755-1.02 nM for BTK.
1
1
1 Cited Publications
Synonyms: CCR1 antagonist 8
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Research Areas:
BI 639667 (compound 19n), a chemical probe, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca 2+ flux assay .
1
1 Cited Publications
Cat. No.: HY-163213
CAS No.: 1352815-11-2
Target:
Research Areas:
Psoralen-triepthylene glycol azide is a compound used to probe the structure and conformation of RNA in living cells, using matching RNA crosslinking and deep sequencing or comradery methods .
1
1 Cited Publications
Target:
Research Areas:
PROTAC ERα Degrader-6 (compound A2) is a potent PROTAC degrader of ERα, with IC50 of 0.11 μM in MCE-7 cells. PROTAC ERα Degrader-6 has anti-tumor effect. PROTAC ERα Degrader-6 is a fluorescent probes with Em of 582 nm that enable real-time visualization of ERα protein degradation .
1
1 Cited Publications
Synonyms: Benzo[def]phenanthrene
1
1 Cited Publications
Cat. No.: HY-112624I
CAS No.: 9004-54-0
Synonyms: Dextran 3; Dextran D3; Dextran T3(MW 2400-3600)
ACBI3 (compound 7), a chemical probe, is a PROTAC targeting KRAS. ACBI3 achieves in vivo degradation of oncogenic KRAS, resulting in durable pathway modulation and tumor regressions in KRAS mutant xenograft mouse models .
Cat. No.: HY-W111141
CAS No.: 1263166-90-0
Synonyms: endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne
Cat. No.: HY-NP080
Synonyms: SNA
Cat. No.: HY-NP087
Synonyms: LCA
Cat. No.: HY-D2775
CAS No.: 3047612-66-5
Cat. No.: HY-W038786
CAS No.: 527-60-6
Cat. No.: HY-W008048
CAS No.: 362-75-4
Target:
Research Areas:
2',3'-O-Isopropylideneadenosine is a nucleoside compound and also a Golgi-targeting moiety. 2',3'-O-Isopropylideneadenosine constitutes a furanose ribose group that undergoes cyclization at the O (2') and O (3') atoms. As a component of the fluorescent probe TPE-Ade, 2',3'-O-Isopropylideneadenosine enables specific Golgi localization for fluorescence imaging. 2',3'-O-Isopropylideneadenosine participates in the synthesis of aggregation-induced emission (AIE) fluorescent probes .
G0507, a pyrrolopyrimidinedione compound, is a potent LolCDE ABC Transporter inhibitor. G0507 is a inhibitor of Escherichia coli growth and induces the extracytoplasmic σE stress response. G0507 acts as a chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
