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rabbit

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Acyltransferase (6) Adenosine Receptor (2) Adenylate Cyclase (7) Adrenergic Receptor (22) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Amino Acid Derivatives (3) AMPK (2) Androgen Receptor (1) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (8) Antibiotic (10) Apolipoprotein (1) Apoptosis (16) Arp2/3 Complex (1) Autophagy (7) Bacterial (22) Bcl-2 Family (1) Biochemical Assay Reagents (37) Bradykinin Receptor (5) Calcium Channel (24) Cannabinoid Receptor (1) Carbonic Anhydrase (10) Carboxylesterase (CES) (1) Carboxypeptidase (1) Casein Kinase (3) Caspase (4) Cathepsin (4) CDK (2) Chloride Channel (1) Cholecystokinin Receptor (1) Complement System (3) COX (10) CXCR (1) Cyclic GMP-AMP Synthase (3) Cytochrome P450 (1) Dipeptidyl Peptidase (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (10) Dopamine Receptor (13) Drug Derivative (15) Drug Intermediate (3) Drug Isomer (4) Drug Metabolite (12) EGFR (1) Elastase (1) Endogenous Metabolite (45) Endothelin Receptor (7) Endothelin-Converting Enzyme (ECE) (1) Environmental Pollutants (13) Epoxide Hydrolase (1) ERK (8) Estrogen Receptor/ERR (2) Eukaryotic Initiation Factor (eIF) (1) Factor Xa (12) Factor XI (1) Fc Receptor (FcR) (2) Ferroptosis (3) FGFR (1) Fluorescent Dye (4) Fructose-1,6-bisphosphate aldolase (1) Fungal (5) GABA Receptor (1) Galectin (1) Glucocorticoid Receptor (1) Glucosylceramide Synthase (GCS) (2) GlyT (3) HCV (1) Heme Oxygenase (HO) (4) Herbicide (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) Histone Methyltransferase (1) HIV (1) HSV (4) IFNAR (1) iGluR (5) Imidazoline Receptor (1) Influenza Virus (1) Insecticide (1) Integrin (4) Interleukin Related (12) Isotope-Labeled Compounds (14) JAK (2) Kallikrein (2) Keap1-Nrf2 (2) Lactate Dehydrogenase (2) LDLR (1) Leukotriene Receptor (2) Lipoxygenase (3) mAChR (6) MEK (2) Melanocortin Receptor (3) Mesothelin (1) MetAP (1) Mitochondrial Metabolism (1) Mitophagy (1) MMP (6) MOFs (1) Molecular Glues (2) Monoamine Oxidase (1) Monoamine Transporter (6) Motilin Receptor (7) Myosin (3) Na+/K+ ATPase (2) nAChR (2) Natriuretic Peptide Receptor (NPR) (1) Necroptosis (1) Neprilysin (1) Neurokinin Receptor (4) Neuropeptide Y Receptor (1) NF-κB (3) NO Synthase (3) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (5) Opioid Receptor (1) P-glycoprotein (1) P2X Receptor (1) P2Y Receptor (3) p38 MAPK (1) Parasite (6) PDGFR (3) PGE synthase (1) Phosphatase (2) Phosphodiesterase (PDE) (12) Phospholipase (8) Phosphorylase (2) Phytohormone (1) PI3K (1) PKA (3) PKC (4) Platelet-activating Factor Receptor (PAFR) (19) Potassium Channel (13) PPAR (2) Progesterone Receptor (7) Prolyl Endopeptidase (PREP) (1) Prostaglandin Receptor (18) Protease Activated Receptor (PAR) (1) Protein Arginine Deiminase (1) Proton Pump (8) PTHR (1) Pyruvate Kinase (2) RANKL/RANK (1) Reactive Oxygen Species (ROS) (10) Reference Standards (41) Renin (1) ROCK (1) SARS-CoV (6) Ser/Thr Protease (2) Serotonin Transporter (6) Sigma Receptor (1) Small Interfering RNA (siRNA) (1) Sodium Channel (5) Src (1) STAT (2) Taste Receptor (3) TGF-beta/Smad (5) Thrombin (6) Thyroid Hormone Receptor (2) TNF Receptor (6) TOPK (5) Topoisomerase (5) Transferrin Receptor (1) Transthyretin (TTR) (1) TRP Channel (2) Tryptophan Hydroxylase (1) Tyrosine Hydroxylase (1) UGT (1) Vasopressin Receptor (2) VEGFR (1) Virus Protease (3) VSV (2) VZV (1) Wnt (3) α-synuclein (1) β-catenin (1)
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50667

Apixaban Maximum Cited Publications 13 Publications Verification BMS-562247-01	Factor Xa	Cardiovascular Disease Cancer
Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

HY-103157

PD146176 5+ Cited Publications NSC168807	Autophagy Ferroptosis	Cardiovascular Disease
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (K_i=197 nM, IC₅₀=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice .

HY-NP002B

Rabbit Serum Albumin	Biochemical Assay Reagents	Inflammation/Immunology
Rabbit Serum Albumin is a plasma protein derived from rabbits. Rabbit Serum Albumin can hydrolyze the carbamate pesticide carbaryl and induce fever in rabbits. Rabbit Serum Albumin can be used for biochemical and immunological research, including vaccine developing .

HY-P2807I

*L-Lactate Dehydrogenase, rabbit* muscle**	Lactate Dehydrogenase	Others
L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research .

HY-B0027

Valnemulin hydrochloride 2 Publications Verification	Antibiotic Bacterial	Infection Metabolic Disease
Valnemulin hydrochloride is an orally effective truncated pleurotin antibiotic that inhibits protein synthesis in bacteria by binding to peptidyl transferase in the 50s ribosome subunit. Valnemulin hydrochloride effectively eliminates Mycobacterium bovis in the lungs in an experimental bovine model of Mycoplasma bovis infection. Valnemulin hydrochloride can reduce the mortality of epidemic rabbit enteropathy and has no adverse effect on the growth performance of rabbits .

HY-139838

Epyrifenacil	Herbicide	Others Cancer
Epyrifenacil is a protoporphyrinogen oxidase (PPO) inhibiting herbicide, potently targeting the PPO₂isoform from weeds such as Amaranthus palmeri with an IC₅₀ of 0.637 nM. Epyrifenacil also inhibits liver mitochondrial PPO across species, with IC₅₀ values of 2.2 nM (mouse), 2.6 nM (rat), 12.1 nM (rabbit), 7.6 nM (dog), and 10.2 nM (human). Epyrifenacil induces liver tumor development in mice. Epyrifenacil can be used for weed control, and also used as a tool compound in toxicological research to study the mechanism of PPO inhibition, chemical-induced hepatotoxicity, and the mode of action of non-genotoxic carcinogens in rodents ^[3].

HY-P0204A

*Endothelin-3, human, mouse, rabbit, rat TFA* 1 Publications Verification Endothelin 3 (Rat,Human) TFA	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis .

HY-108573

P-1075 1 Publications Verification	Potassium Channel	Cardiovascular Disease
P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-K_IR6), with an EC₅₀ value of 45 nM for SUR2B-K_IR6 channel activation . P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts .

HY-N6662

(+)-Longifolene	Environmental Pollutants Endogenous Metabolite	Others
(+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant .

HY-P2726

*Aldolase, Rabbit* muscle** Fructose-diphosphate aldolase	Fructose-1,6-bisphosphate aldolase Endogenous Metabolite	Metabolic Disease
Aldolase, Rabbit muscle (Fructose-diphosphate aldolase) is a glycolytic enzyme and glucose availability sensor. Aldolase, Rabbit muscle catalyzes the reversible carbon-carbon cleavage of fructose-1,6-bisphosphate to produce dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. Aldolase, Rabbit muscle is an essential component for v-ATPase activity. Aldolase, Rabbit muscle participates in processes such as gluconeogenesis, the Calvin cycle and glycolysis .

HY-P2952

*Recombinant myokinase, Rabbit* muscle** Myokinase; Adk	Endogenous Metabolite	Others
Recombinant myokinase, Rabbit muscle (Myokinase), is a phosphotransferase enzyme, is often used in biochemical studies. Recombinant myokinase, Rabbit muscle catalyzes the interconversion of adenosine phosphates. Recombinant myokinase, Rabbit muscle monitors phosphate nucleotide levels inside the cell, it plays an important role in cellular energy homeostasis .

HY-P2799

*Creatine phosphokinase, Rabbit* muscle** 1 Publications Verification CPK	Endogenous Metabolite	Metabolic Disease Cancer
Creatine phosphokinase, Rabbit muscle (CPK) catalyzes the reversible reaction of creatine and ATP to form phosphocreatine and ADP. Creatine phosphokinase is a key enzyme for maintaining a constant ATP/ADP ratio during rapid energy turnover .

HY-113511B

*Glycogen, from rabbit* liver, ≥85%**	Endogenous Metabolite	Metabolic Disease
Glycogen, from rabbit liver, ≥85% is glycogen extracted from rabbit liver. Glycogen, from rabbit liver, ≥85% is a branched polysaccharide condensed from glucose and serves as a storage form of glucose in the body. Glycogen, from rabbit liver, ≥85% plays an important role in physiological processes such as maintaining blood sugar and providing energy .

HY-P0204

*Endothelin-3, human, mouse, rabbit, rat* 1 Publications Verification Endothelin 3 (Rat,Human)	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis .

HY-P2806A

*Pyruvate Kinase (PK),Rabbit* Muscle** ATP:Pyruvate 2-0-phosphotransferase,PK	Pyruvate Kinase	Metabolic Disease Cancer
Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research .

HY-P3564

*(D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)*	Melanocortin Receptor	Others
(D-Ser1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is an adrenocorticotropic hormone (ACTH) analogue .

HY-50667S

Apixaban-13C,d3 BMS-562247-01-¹³C,d₃	Factor Xa	Cardiovascular Disease
Apixaban- ¹³C,d₃ (BMS-562247-01- ¹³C,d₃) is a deuterium and ¹³C labeled Apixaban (HY-50667). Apixaban is a highly selective, reversible inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively .

HY-117290

BMS-962212	Factor Xa	Cardiovascular Disease
BMS-962212 is a factor XIa (FXIa) inhibitor with a K_i of 0.7 nM against human FXIa and a K_i of 3 nM against rabbit FXIa. BMS-962212 blocks thrombosis while preserving normal hemostatic function. BMS-962212 is applicable to thrombosis-related research .

HY-W583212

Zn(II) Mesoporphyrin IX ZnMP	Biochemical Assay Reagents Heme Oxygenase (HO)	Inflammation/Immunology
Zn (II) Mesoporphyrin IX (ZnMP) is a heme oxygenase inhibitor with photochemical substrate activity. Zn (II) Mesoporphyrin IX specifically inhibits the activity of bone marrow heme oxygenase. In vitro, Zn (II) Mesoporphyrin IX inhibits the growth of erythroid and myeloid progenitor cells in rabbit bone marrow, and blocks the rhG-CSF-induced mobilization of these progenitor cells into the peripheral blood, exhibiting toxicity to hematopoietic growth and progenitor cell production in rabbits. Zn (II) Mesoporphyrin IX undergoes irreversible photochemical decomposition conforming to first-order kinetic characteristics when irradiated with UV-B in 95% ethanol solution. Zn (II) Mesoporphyrin IX can be used in hematopoietic regulation research, but its photolability and toxic effects on the hematopoietic system require attention .

HY-B1608

Chromium chloride		Cardiovascular Disease Metabolic Disease
Chromium chloride is a trivalent chromium compound and an essential trace mineral. Chromium chloride enhances insulin-stimulated GLUT4 translocation and glucose uptake in skeletal muscle. Chromium chloride regulates glucose and lipid metabolism, inhibits TNF-α secretion and oxidative stress in monocytes treated with high glucose or H₂O₂, and reverses hydrogen peroxide-induced cell growth inhibition. Chromium chloride reduces coronary and aortic lipid deposition and serum cholesterol levels in hypercholesterolemic rabbits. Chromium chloride can be used in research related to diabetes and cardiac atherosclerosis .

HY-114266

UC-1728 t-TUCB	Epoxide Hydrolase	Cardiovascular Disease Inflammation/Immunology
UC-1728 is a potent rabbit soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 2 nM on rabbit liver.

HY-P2820

*Phosphoglucomutase, Rabbit* muscle**	Endogenous Metabolite	Metabolic Disease
Phosphoglucomutase, Rabbit muscle is often used in biochemical studies. Phosphoglucomutase is an enzyme that can transfer the phosphate group on the α-D-glucose monomer forward from the 1-position to the 6-position or reversely transfer from the 6-position to the 1-position, and promote the glucose-1-phosphate and glucose-6-phosphate Transform each other. Phosphoglucomutase is a key enzyme in glycolysis and gluconeogenesis, and plays an important role in the metabolism of proteins, lipids and nucleic acids .

HY-P2765

*Glycerol-3-phosphate dehydrogenase, rabbit* muscle** GPDH; α-Glycerophosphate dehydrogenase; Glycerol phosphate dehydrogenase	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate dehydrogenase, rabbit muscle (GPDH) is an enzyme that catalyzes the reversible redox conversion of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. Glycerol-3-phosphate dehydrogenase is a glycolytic enzyme and is responsible for the re-oxidation of NADH to NAD ⁺ and energy supply .

HY-P2918

*Phosphoglucose Isomerase, Rabbit* muscle** GPI; Phosphoglucose Isomerase	Endogenous Metabolite	Metabolic Disease Cancer
Phosphoglucose Isomerase, Rabbit muscle (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved glycolytic and dimeric enzyme. Glucose 6-phosphate isomeras catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate .

HY-50667R

Apixaban (Standard) BMS-562247-01 (Standard)	Reference Standards Factor Xa	Cardiovascular Disease Cancer
Apixaban (Standard) is the analytical standard of Apixaban. This product is intended for research and analytical applications. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

HY-B1796

Thymol iodide	Fungal	Infection
Thymol iodide is an iodine derivative of thymol, serving as a mild preservative and fungicide. Thymol iodide is commonly used as an iodine source in the intensive culture of rotifers. Thymol iodide effectively enables Brachionus "Cayman" rotifers to reach iodine levels similar to those of copepods, and maintains a high iodine content during storage. After 28 days of intrapleural injection of Thymol iodide, it does not enhance the efficacy of inducing pleurodesis in rabbits, nor does it improve the efficacy of talc slurry pleurodesis .

HY-P2734

*Phosphorylase a, rabbit* muscle**	Phosphatase	Others
Phosphorylase a, rabbit muscle is glycogen phosphorylase isolated from rabbit muscle. Phosphorylase a, rabbit muscle catalyzes glycogenolysis, converting glycogen and inorganic phosphate into glucose-1-phosphate to supply energy for muscle contraction .

HY-NP0198

Rabbit Immunoglobulin G rabbit IgG	Biochemical Assay Reagents	Inflammation/Immunology
Rabbit Immunoglobulin G (Rabbit IgG) is a rabbit serum immunoglobulin that can be used in immunolabeling and coating protein in a variety of immunoassays including ELISA .

HY-125864D

Rabbit Fibrinogen	Interleukin Related NF-κB	Cardiovascular Disease
Rabbit Fibrinogen is a native fibrinogen from rabbit plasma. Fibrinogen is a selective proteolytic molecule that can be activated by thrombin to assemble fibrin clots. Fibrinogen can regulate the activation of NF-KB in endothelial cells and upregulate the expression of inflammatory chemokines MCP-1 and MCP-1. Fibrinogen plays a key role in blood clotting, thrombosis, atherosclerosis and the pathological development of venous grafts, and can be used in the study of blood clotting and vascular diseases .

HY-P3069

*γ-Neuropeptide (rabbit)*	Neurokinin Receptor	Neurological Disease Endocrinology
γ-Neuropeptide (rabbit) can be isolated from rabbit intestine. γ-Neuropeptide is an endogenous neurokinin peptide that acts as a neurokinin 2 (NK2) receptor agonist. γ-Neuropeptide mediates hypothalamic-pituitary-adrenal (HPA) axis, as well as reproductive hormone release .

HY-W012168

4-Chloro-3-sulfamoylbenzoic acid	Carbonic Anhydrase	Metabolic Disease
4-Chloro-3-sulfamoylbenzoic acid is a weak inhibitor of human carbonic anhydrase isoforms hCA I, hCA II, hCA IV, and hCA IX, and a synthesis intermediate for carbonic anhydrase inhibitors. 4-Chloro-3-sulfamoylbenzoic acid is the major metabolite of tripamide detected in tissues, urine, and feces of rats and rabbits following Tripamide (HY-106570) administration. 4-Chloro-3-sulfamoylbenzoic acid can be used for the study of carbonic anhydrase inhibition and species differences in drug metabolism .

HY-NP002C

Rabbit Serum Albumin (globulin free)	Biochemical Assay Reagents	Others
Rabbit Serum Albumin (globulin free) is a plasma protein derived from rabbits. Serum albumin is a multifunctional protein with extraordinary ligand binding capacity, making it a transporter molecule for a diverse range of metabolites, drugs, nutrients, metals and other molecules .

HY-114164E

Rabbit Thrombin	Thrombin	Cardiovascular Disease
Rabbit Thrombin is a Na ⁺-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Thrombin recognition sequence and can be used to digest GST-tagged proteins .

HY-P3977

*ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)*	Melanocortin Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease .

HY-P3566

*(D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)*	Biochemical Assay Reagents	Others
(D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the reaction product with gadolinium tetraazacyclododecanetriacetate derivative. (D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) involves in preparation of tetraazacyclododecane macrocycle metal complexes for production of conjugates with biomolecules and for use as NMR contrast agents, radiodiagnostic agents and for radioresearch .

HY-P4798

*Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)* Human PTHrP(107-111) amide	PTHR	Others
Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) is a C-terminal parathyroid hormone-related protein fragment that can inhibit bone resorption .

HY-119431

Lactamide 2-Hydroxypropanamide	Biochemical Assay Reagents	Others
Lactamide (2-Hydroxypropanamide) is an amide compound. Lactamide can be used as a cryoprotectant and is employed in experiments for the cryopreservation of white rabbit sperm .

HY-106327

EM-523	Motilin Receptor	Metabolic Disease
EM-523 is a motilin agonist and an erythromycin derivative. EM-523 has pED₅₀ values of 8.19 and 6.08 for promoting contractions in rabbit small intestinal tissue and human duodenal tissue, respectively. EM-523 can be used in the research of gastrointestinal diseases .

HY-P3009C

Rabbit Factor Xa	Factor Xa	Cardiovascular Disease
Rabbit Factor Xa is prepared by activating purified Rabbit Factor X with Russells' Viper Venom, after which the Russells' Viper Venom is removed.

HY-17019

SL-89.0591	Adrenergic Receptor	Inflammation/Immunology
SL-89.0591 is a uroselective α1-adrenoceptor antagonist. SL-89.0591 exhibits a more potent blocking effect on urethral receptors than on vascular receptors in anesthetized rabbits, with a lower risk of orthostatic hypotension. SL-89.0591 can be used in research related to benign prostatic hyperplasia .

HY-105263

EM574	Motilin Receptor	Metabolic Disease
EM574 is a potent motilin receptor agonist in the human gastric antrum and rabbit gastrointestinal tract in vitro. EM574 is an erythromycin derivative .

HY-112348

HA-1004 hydrochloride	Cyclic GMP-AMP Synthase PKA ERK Calcium Channel	Cardiovascular Disease Metabolic Disease
HA-1004 hydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 hydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein (Cyclic GMP-AMP Synthase), and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 hydrochloride an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models .

HY-125064

AP22408	Src	Cancer
AP22408 is a nonpeptide inhibitor against Src SH2 with an IC₅₀ value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy .

HY-P5631

Rabbit neutrophil peptide 3b	Bacterial	Infection
Rabbit neutrophil peptide 3b is an antimicrobial peptide derived from rabbit peritoneal neutrophils .

HY-P2458

*CAP18 (rabbit)*	Bacterial	Infection
CAP18 (rabbit) is a 37 amino acids antimicrobial peptide originally isolated from rabbit granulocytes. CAP18 (rabbit) has broad antimicrobial activity against both Gram-positive (IC₅₀, 130-200 nM) and Gram-negative (IC₅₀, 20-100 nM) bacteria. CAP18 (rabbit) has the potential for bacterial sepsis research .

HY-NP0198B

Rabbit IgG Fab fragment	Fc Receptor (FcR)	Inflammation/Immunology
Rabbit IgG Fab fragment is a fragment of antigen (Fab) of rabbit immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.

HY-NP0198A

Rabbit IgG Fc fragment	Fc Receptor (FcR)	Inflammation/Immunology
Rabbit IgG Fc fragment is a crystallizable fragment (Fc) of rabbit immunoglobulin G (IgG) molecules that can be used as an immunolabel in various immunoassays, including ELISA.

HY-P2995C

Rabbit Hemoglobin	Biochemical Assay Reagents Heme Oxygenase (HO)	Others
Rabbit Hemoglobin is a hemoglobin derived from rabbit. Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant .

HY-E70124C

*Esterase, Rabbit* liver**	Biochemical Assay Reagents	Metabolic Disease
Esterase, Rabbit liver is a carboxylate hydrolase. Esterase, Bacillus subtilis accepts a branched alcohol moiety as substrate .

HY-NP0194B

*C1q Protein (rabbit)*	Complement System	Inflammation/Immunology
C1q Protein (rabbit) is a complement protein and is a recognition molecule of the classical pathway, performs a diverse range of complement and non-complement functions. C1q Protein (rabbit) binds various ligands derived from self, non-self, and altered self and modulate the functions of immune and non-immune cells. C1q Protein (rabbit) can be used for the research of mutiple disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0132

N-Acetyl-D-glucosamine 2 Publications Verification N-Acetyl-2-amino-2-deoxy-D-glucose	Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Source Classification	Endogenous Metabolite Drug Derivative Drug Isomer Interleukin Related
N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .

HY-I0660

Picolinic acid 1 Publications Verification PCL 016	Infection Structural Classification Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Source Classification	MOFs Endogenous Metabolite Virus Protease
Picolinic acid (PCL 016) is a topical antiviral agent, which inhibits adenovirus replication in rabbits.

HY-N0134

Tanshinone I 5 Publications Verification Tanshinone A	Classification of Application Fields Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Source Classification Cancer	Phospholipase
Tanshinone I is an inhibitor of type IIA human recombinant sPLA₂ (IC₅₀=11 μM) and rabbit recombinant cPLA₂ (IC₅₀=82 μM).

HY-W017522

Adipic acid Hexanedioic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Cancer Source Classification	Environmental Pollutants Endogenous Metabolite HSV
Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .

HY-W010128

6-(Dimethylamino)purine 6-Dimethylaminopurine; 6-DMAP	Classification of Application Fields Other Diseases Disease Research Fields	CDK DNA/RNA Synthesis Apoptosis
6-(Dimethylamino) purine (6-Dimethylaminopurine) is a serine threonine protein kinase inhibitor. 6-(Dimethylamino) purine can inhibit prolactin induced expression of lactoprotein genes in rabbit mammary gland cells. 6-(Dimethylamino) purine can affect the maturation of mammalian oocytes. 6-(Dimethylamino) purine can lead to downregulation of genes related to cell proliferation and cell cycle progression, such as proliferating cell nuclear antigen, insulin-like gene 1, and serine protease inhibitor 2 genes, and induce apoptosis in lymphoma cells (apoptosis) .

HY-113202

Stearoylcarnitine 1 Publications Verification	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite PKC GlyT
Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-N6662

(+)-Longifolene	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
(+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant .

HY-126573

Trilaurin	Structural Classification Classification of Application Fields Endogenous metabolite Disease Research Fields Lipid Source Classification Cancer	Endogenous Metabolite Biochemical Assay Reagents
Trilaurin is an orally active triglyceride. Trilaurin inhibits DMBA-induced, croton oil-promoted skin tumor formation in Swiss Webster mice. Trilaurin increases plasma high-density lipoprotein cholesterol and apolipoprotein A-I concentrations. Trilaurin is used as an occlusive skin conditioning agent and/or non-aqueous thickener in cosmetics .

HY-N0120

(E/Z)-Polydatin (E/Z)-Piceid	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Drug Isomer
(E/Z)-Polydatin ((E/Z)-Piceid) is a mixture of the E/Z configurations of Polydatin (HY-N0120A). Polydatin can be isolated from Polygonum cuspidatum, grapes, peanuts, red wine, hop pellets, cocoa-containing products and chocolate products. Polydatin exhibits multiple biological properties, such as anti-platelet aggregation, anti-low-density lipoprotein oxidation, cardioprotective activity, anti-inflammatory and immunomodulatory functions. Polydatin shows favorable cytotoxic effects against various tumor cell lines, including cervical cancer cells, liver cancer cells, and nasopharyngeal carcinoma cells .

HY-W015780

1,4-Dimethoxybenzene	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
1,4-Dimethoxybenzene is an endogenous metabolite. 1,4-Dimethoxybenzene has an anti-anxiety effect, increasing atherogenic index (AI) levels in rabbits and inducing sedentary behavior. Sedentary behavior may increase blood cholesterol levels and disrupt blood lipids . 1,4-Dimethoxybenzene considers to be not clastogenic in the in vivo micronucleus test .

HY-122958

Peucedanocoumarin III	Structural Classification Carpesium cernuum L. Coumarins Phenylpropanoids Umbelliferae Plants Source Classification	α-synuclein
Peucedanocoumarin III is an α-synuclein fiber depolymerizer with blood-brain barrier permeability. Peucedanocoumarin III depolymerizes β-sheet aggregate structures, promotes aggregate clearance, inhibits β23-induced cytotoxicity, blocks the formation of Lewy body-like inclusions, and prevents dopaminergic neuron loss. Peucedanocoumarin III can be used in studies related to Parkinson's disease .

HY-N4087

Platycodin D2 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification Cancer	Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .

HY-113247

trans-trans-Muconic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite
trans-trans-Muconic acid is a urinary metabolite of Benzene. trans-trans-Muconic acid serves as a urinary biomarker for occupational benzene exposure .

HY-W019151

Meconine	Natural Products Classification of Application Fields Metabolic Disease Papaver somniferum Linn. Plants Endogenous metabolite Disease Research Fields Papaveraceae Source Classification	Endogenous Metabolite
Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use .

HY-111247

Ro 09-0680	Ketones, Aldehydes, Acids Labiatae Samanea saman (Jacq.) Merr. Plants Source Classification	Others
Ro 09-0680 is a potent inhibitor of rabbit platelet aggregation induced by Collagen with an IC₅₀ of 6.6 μM .

HY-N2503

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N10348

Progoitrin	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Glucosinolates Plants Brassica napus var. napobrassica (L.) Rchb. Brassicaceae Disease Research Fields Endocrinology Source Classification	Others Drug Derivative
Progoitrin is a sulfur-containing glucosinolate, as well as a naturally occurring orally active thioglycoside. Progoitrin acts as a hepatotoxin and antithyroid agent. Progoitrin is quantitatively converted to goitrin in vivo, including via a gastrointestinal hydrolysis pathway that does not require exogenous myrosinase, thereby blocking the organification of iodine in the thyroid gland and inhibiting the uptake and accumulation of radioactive iodine. Progoitrin can be used in studies related to Graves' disease .

HY-118824A

N-Feruloylserotonin (E/Z)-Moschamine	Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Carthamus tinctorius L. Phenols Polyphenols Plants Compositae Disease Research Fields Indole Alkaloids Source Classification	Calcium Channel PDGFR ERK
N-Feruloylserotonin ((E/Z)-Moschamine) is a serotonin hydroxycinnamic acid amide. It can be isolated from a variety of plants, particularly the seeds of safflower (Carthamus tinctorius L.). N-Feruloylserotonin inhibits KCl- and 5-HT-induced elevation of intracellular [Ca ²⁺]_i. It suppresses PDGF-BB-induced phosphorylation of PDGFRβ and ERK1/2. N-Feruloylserotonin exerts anti-inflammatory effects on aortic endothelial cells. It inhibits atherosclerotic plaque formation in apolipoprotein E-deficient mice .

HY-I0660R

Picolinic acid (Standard) PCL 016 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Virus Protease
Picolinic acid (Standard) is the analytical standard of Picolinic acid. This product is intended for research and analytical applications. Picolinic acid (PCL 016) is a topical antiviral agent, which inhibits adenovirus replication in rabbits.

HY-W019151R

Meconine (Standard)	Structural Classification Natural Products Papaver somniferum Linn. Plants Endogenous metabolite Papaveraceae Source Classification	Reference Standards Endogenous Metabolite
Meconine (Standard) is the analytical standard of Meconine (HY-W019151). This product is intended for research and analytical applications. Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N3931

Gardneramine	Alkaloids Nepenthes mirabilis (Lour.) Druce Plants Nepenthaceae Source Classification	Others
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .

HY-N1210

Spiramine A Spiramine C acetate (ester)	Alkaloids Other Alkaloids Terpenoids Rosaceae Spiraea japonica Diterpenoids Plants Source Classification	Bacterial
Spiramine A (Spiramine C acetate (ester)) is a diterpene alkaloid with antitumor and antimicrobial activity. Spiramine A inhibits PAF-induced rabbit platelet aggregation in a concentration-dependent manner, with an IC₅₀ vallue of 6.7 μM .

HY-N11056

Justicidin C	Acanthaceae Lignans Phenylpropanoids Plants Duhaldea wissmanniana (Hand.-Mazz.) Anderb. Source Classification	Antibiotic VSV
Justicidin C is an antiviral lignan. Justicidin C shows strong antiviral activity against vesicular stomatitis virus and low cytotoxicity against rabbit lung cells (RL-33) .

HY-127127

Deamino-NAD	Microorganisms Source Classification	Endogenous Metabolite
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-N8218

Homoeriodictyol 7-O-β-D-glucoside	Cardiovascular Disease Flavonoids Viscum coloratum (Kom.) Nakai Classification of Application Fields Flavonones Phenols Polyphenols Plants Loranthaceae Disease Research Fields Source Classification	Platelet-activating Factor Receptor (PAFR)
Homoeriodictyol 7-O-β-D-glucoside is a natural platelet-activating factor (PAF) antagonist. Homoeriodictyol 7-O-β-D-glucoside inhibits human and rabbit platelet aggregation induced by PAF, with an IC₅₀ of 0.8 μM .

HY-N12995

α-Bulnesene	Entada phaseoloides (L.) Merr. Terpenoids Labiatae Sesquiterpenes Plants Source Classification	Platelet-activating Factor Receptor (PAFR)
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-129278

Lunarine	Alkaloids Lunaria annua L. Other Alkaloids Plants Brassicaceae Source Classification	Parasite
Lunarine is an alkaloid, which can be isolated from the seeds of kale (Lunaria annua). Lunarine lowers the blood pressure, stimulates small intestinal motility, inhibits spontaneous contractions of uterus and nervous system, and exhibits an acute toxicity with LD₅₀ of 62.3 mg/kg in dogs and rabbits. Lunarine exhibits antiparasitic activity through a competitive inhibition of protozoan oxidoreductase trypanothione reductase (TryR) with K_i of 304 μM .

HY-N6609

Magnocurarine	Alkaloids Structural Classification Classification of Application Fields Other Diseases Phenols Polyphenols Plants Cissampelos pareira Isoquinoline Alkaloids Menispermaceae Disease Research Fields Source Classification	nAChR
Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .

HY-W472451

Linalyl isobutyrate	Structural Classification Other Monoterpenes Terpenoids Rutaceae Plants Citrus reticulata Blanco Source Classification	Biochemical Assay Reagents
Linalyl isobutyrate is a fragrance ingredient. Linalyl isobutyrate produces very slight erythema .

HY-N11932

Piperulin A	Lignans Piperaceae Phenylpropanoids Plants Piper hongkongense C. de Candolle Source Classification	Platelet-activating Factor Receptor (PAFR)
Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC₅₀ of 7.3 μM .

HY-N13880

Adustin	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Adustin, an antifungal antibiotic, is a polypeptide with translation-inhibiting activity. Adustin inhibits translation in a cell-free rabbit reticulocyte lysate system with an IC₅₀ of 0.34 μM .

HY-P5685

Maximin 49	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Maximin 49 is an antimicrobial peptide. Maximin 49 has antibacterial activity against S. aureus (MIC: 18.8 μg/mL). Maximin 49 has hemolytic activities against human and rabbit red cells .

HY-126645

Atelopidtoxin	Natural Products Animals Animal Venoms Source Classification	Sodium Channel
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-N4080

Cyclobuxine D	other families Classification of Application Fields Plants Disease Research Fields Inflammation/Immunology Steroids Source Classification	mAChR
Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba ⁺⁺−induced contraction of the longitudinal muscle isolated from the rabbit jejunum .

HY-N12070

11-O-β-D-glucopyranosyl thamnosmonin	Coumarins Phenylpropanoids Cynara scolymus L. Umbelliferae Plants Source Classification	Others
11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP .

HY-P5683

Maximin 45	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Maximin 45 is an antimicrobial peptide. Maximin 41 has antibacterial activity against S. aureus, E. coli, B. subtilis (MIC: 4.7, 9.4, 75 μg/mL). Maximin 45 has hemolytic activities against human and rabbit red cells .

HY-N0134R

Tanshinone I (Standard) Tanshinone A (Standard)	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants Source Classification	Reference Standards Phospholipase
Tanshinone I (Standard) is the analytical standard of Tanshinone I. This product is intended for research and analytical applications. Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC₅₀=11 μM) and rabbit recombinant cPLA2 (IC₅₀=82 μM).

HY-P0004R

Lysipressin (Standard) Lysine vasopressin (Standard); [Lys8]-Vasopressin (Standard)	Structural Classification Monophenols Animals Phenols Source Classification	Reference Standards Adenylate Cyclase
Lysipressin (Standard) is the analytical standard of Lysipressin. This product is intended for research and analytical applications. Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-P5686

Maximin 78	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial
Maximin 78 is an antimicrobial peptide. Maximin 78 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 37.5, 4.7, 37.5 μg/mL). Maximin 78 has hemolytic activities against human and rabbit red cells .

HY-129665

GS-389 (±)-O,O-Dimethylcoclaurine	Alkaloids Cocculus laurifolius DC. Plants Isoquinoline Alkaloids Menispermaceae Source Classification	Endogenous Metabolite
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K ⁺ in rat aortic rings .

HY-123100R

Ganoderic acid N (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Terpenoids Polyporaceae Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Endogenous metabolite Source Classification	Reference Standards Others
Isoxepac (Standard) is the analytical standard of Isoxepac. This product is intended for research and analytical applications. Isoxepac (HP 549) is a nonsteroidal anti-inflammatory agent (NSAID) with anti-inflammatory, analgesic and antipyretic activity. Isoxepac has been studied in rat, rabbit, dog, rhesus monkey, etc .

HY-P5684

Maximin H39	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Maximin H39 is an antimicrobial peptide. MaximinH39 has antibacterial activity against C. albicans, S. aureus, B. subtilis (MIC: 9.4, 9.4, 18.8 μg/mL). Maximin H39 has hemolytic activities against human and rabbit red cells .

HY-N3289A

(E)-Methyl 3,4,5-trimethoxycinnamate	Simple Phenylpropanols Piper tuberculatum jacq. Piperaceae Phenylpropanoids Plants Source Classification	Others
(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .

HY-116778

Prostaglandin G2	Source Classification	Reactive Oxygen Species (ROS)
Prostaglandin G2 is a prostaglandin peroxide. Prostaglandin G2 acts as a precursor for thromboxane A₂ production, inducing platelet aggregation and serotonin release. Prostaglandin G2 also induces cerebral arteriole injury in anesthetized cats via the generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage. Prostaglandin G2 can be used in studies related to cerebral arteriole injury .

HY-W130596

3-Phenylpropyl acetate	Structural Classification Natural Products Psidium guajava Linn. Myrtaceae Plants Source Classification	Environmental Pollutants
3-Phenylpropyl acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). 3-Phenylpropyl acetate has acute toxicity in rats and rabbits and shows no skin sensitization in guinea pigs. 3-Phenylpropyl acetate can be used as a fragrance ingredient .

HY-N6609B

Magnocurarine chloride	Structural Classification Alkaloids Tiliacora racemosa Colebr. Plants Isoquinoline Alkaloids Menispermaceae Source Classification	nAChR
Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .

HY-N17892

Ariskanin A	Structural Classification Natural Products Aristolochia zollingeriana Miq. Plants Aristolochiaceae Source Classification	Others
Ariskanin A is a platelet aggregation inhibitor that exists in Aristolochia kankauensis and Aristolochia manshuriensis. Ariskanin A inhibits rabbit platelet aggregation .

HY-180696

Adenosine tetraphosphate	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
Adenosine tetraphosphate is a natural nucleotide present in many biological systems. Adenosine tetraphosphate produces a reduction in the intraocular pressure in normotensive rabbit eyes .

HY-169788

Graveolinine	Alkaloids Ruta chalepensis var. latifolia Quinoline Alkaloids Plants Asparagaceae Juss. Source Classification	Others
Graveolinine is a quinoline alkaloid, that can be isolated from Ruta chalepensis. Graveolinine exhibits antiplatelet activity, that reduces Arachidonic Acid (HY-109590)- and Collagen-induced aggregation of washed rabbit platelets .

Cat. No.	Product Name	Chemical Structure

HY-B0590S

Tetrabenazine-d6

Tetrabenazine-d₆ (Deutetrabenazine) is a deuterium-labled Tetrabenazine (HY-B0590). Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-50667S

Apixaban-13C,d3
Apixaban- ¹³C,d₃ (BMS-562247-01- ¹³C,d₃) is a deuterium and ¹³C labeled Apixaban (HY-50667). Apixaban is a highly selective, reversible inhibitor of Factor Xa with K_i of 0.08 nM and 0.17 nM in human and rabbit, respectively .

HY-50667S1

Apixaban-d3
Apixaban-d3 (BMS-562247-01-d3) is the deuterium labeled Apixaban (HY-50667) . Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with K_is of 0.08 nM and 0.17 nM in human and rabbit, respectively . Apixaban is in development for the prevention and treatment of various thromboembolic diseases .

HY-17357S

Nepafenac-d5

Nepafenac-d₅ (AHR-9434-d₅; AL-6515-d₅) is the deuterium labeled Nepafenac (HY-17357). Nepafenac, a nonsteroidal anti-inflammatory agent, is a topically administered COX-2 inhibitor with an IC₅₀ of 0.12 μM. Nepafenac exhibits only weak COX-1 inhibitory activity (IC₅₀ = 64.3 μM). Nepafenac possesses unique prodrug properties, which enable it to rapidly convert into the active metabolite Amfenac (HY-17479) in the ocular tissues, thereby achieving high concentrations in the retina and choroid. Nepafenac reduces inflammation and pain by inhibiting the activity of cyclooxygenase (COX) enzymes and thereby decreasing the production of prostaglandin PGE_₂. Nepafenac can delay the metastasis of uveal melanoma (UM) in rabbit eyes. Nepafenac is mainly used for pain management and inflammation control after ophthalmic surgeries.

HY-W019151S

Meconin-d3
Meconin-d₃ is the deuterium labeled Meconine (HY-W019151). Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.

HY-13402S

Varespladib-d7

Varespladib-d₇ (LY315920-d₇) is a deuterated labeled Varespladib (HY-13402). Varespladib is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC₅₀ of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC₅₀s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .

HY-113202S

Stearoyl-L-carnitine-d3

Stearoyl-L-carnitine-d₃ is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-13511AS

Rupatadine-d4 fumarate
Rupatadine-d₄ fumarate is a deuterium labeled Rupatadine fumarate. Rupatadine Fumarate (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with K_i values of 0.55/0.1 μM (rabbit platelet membranes/guinea pig cerebellum membranes) .

HY-B1287S

Citalopram-d3 hydrobromide

Citalopram-d₃ ((±)-Citalopram-d₃) hydrobromide is deuterium labeled Citalopram (hydrobromide). Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI). Citalopram hydrobromide inhibits 5-HT uptake into synaptosomes with an IC₅₀ of 1.8 nM. Citalopram hydrobromideinhibits the 5-HT uptake in rabbit blood platelets with an IC₅₀ of 14 nM. Antidepressant effect .

HY-B1095S1

Chlormadinone acetate-d6-1

Chlormadinone acetate-d₆-1 is deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-B1095S2

Chlormadinone acetate-d3

Chlormadinone acetate-d₃ is the deuterium labeled Chlormadinone acetate (HY-B1095). Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders .

HY-113202S1

Stearoyl-L-carnitine-d9 chloride

Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2 .

HY-A0132S14

N-Acetyl-D-glucosamine-d3

N-Acetyl-D-glucosamine-d₃ (N-Acetyl-2-amino-2-deoxy-D-glucose-d₃) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits .

HY-166478S

O-Desmethyl carvedilol-d5

O-Desmethyl carvedilol-d₅ (Desmethylcarvedilol-d₅) is deuterium labeled O-Desmethylcarvedilol. O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 ^R4496C) mutation (IC₅₀ = 7.62 μM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED₅₀s = 32 and 5 μg/kg, respectively) .

HY-B0590S3

Tetrabenazine-d7

Tetrabenazine-d₇ (TBZ-d₇-d₇) is deuterium labeled Tetrabenazine (HY-B0590). Tetrabenazine (Ro 1-9569) is a brain-penetrant and orally active VMAT2-selective ligand with human VMAT2 K_i 100 nM. Tetrabenazine binds VMAT2 to block monoamine uptake into synaptic vesicles, potentiates cytoplasmic monoamine degradation. Tetrabenazine weakly blocks dopamine D2 receptors, and increases dopamine turnover via elevated cerebrospinal fluid homovanillic acid. Tetrabenazine can be used for the research of Huntington’s disease, tardive dyskinesia, and Tourette’s syndrome .

HY-N6662S

(+)-Longifolene-13C,d2
(+)-Longifolene- ¹³C,d₂ is the ¹³C- and deuterium labeled (+)-Longifolene (HY-N6662). (+)-Longifolene is a sesquiterpenoid and a metabolite in rabbits. (+)-Longifolen is converted to primary, secondary or tertiary alcohols in rabbits, among which the primary alcohol is predominant .

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