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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
skin hyperpigmentation
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "skin hyperpigmentation" in MCE Product Catalog:
Cat. No.: HY-N3002
CAS No.: 84380-01-8
Synonyms: 4-Hydroxyphenyl α-D-glucopyranoside
Category:
Monophenols Metabolic Disease Phenols Ericaceae Extract Cosmetic Research Plants Disease Research Fields
Target:
Cat. No.: HY-P3452
CAS No.: 1036207-61-0
Target:
Research Areas:
Cat. No.: HY-N3200
CAS No.: 53734-74-0
Target:
Target:
TSPO TRP Channel Microphthalmia Associated Transcription Factor (MITF) PKC PKA p38 MAPK PERK Interleukin Related
Research Areas:
FGIN-1-27 is a blood-brain barrier-penetrant TSPO ligand with a Ki value of 5 nM. FGIN 1-27 inhibits PKC-β, PKA/CREB, p38/ERK MAPK, MITF, tyrosinase, TRP-1, and TRP-2, thereby inhibiting melanogenesis and pigmentation. FGIN-1-27 alleviates X-ray radiation-induced astrocyte mitochondrial hyperfunction, reduces ROS and superoxide production, inhibits excessive activation of A1-type astrocytes, downregulates GFAP and C3 protein expression, and restores astrocyte proliferative capacity. FGIN-1-27 produces anticonvulsant effects in normal mice; in diazepam-withdrawn mice, the brain MDR pathway becomes subsensitive, and the anticonvulsant activity disappears. FGIN-1-27 attenuates pigmentation in zebrafish embryos and ameliorates UVB-induced skin pigmentation in guinea pigs. FGIN-1-27 directly stimulates testicular Leydig cells while upregulating luteinizing hormone levels, causing an acute increase in serum testosterone in male rats. FGIN 1-27 can be used for research related to hyperpigmentation, epilepsy, brain injury, and other diseases .
Category:
Alkaloids Metabolic Disease Phenols Polyphenols Nymphaeaceae Extract Nelumbo nucifera Gaertn. Plants Disease Research Fields Isoquinoline Alkaloids
Target:
Target:
Research Areas:
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .
Target:
Research Areas:
4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent. 4-Isopropylcatechol significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. 4-Isopropylcatechol can be use to study hyperpigmentation of skins .
Cat. No.: HY-W000873
CAS No.: 146631-00-7
Target:
Research Areas:
4-Benzyloxyphenylboronic acid is an arylboronic acid reagent that generates Monobenzone (HY-30272), a compound that inhibits melanin production in the skin, via electrochemical deboronation hydroxylation. 4-Benzyloxyphenylboronic acid serves as a coupling partner in Pd (0)-catalyzed Suzuki-Miyaura cross-coupling reactions for the synthesis of bent-core liquid crystals and liquid crystalline amphiphiles. 4-Benzyloxyphenylboronic acid is used in the study of hyperpigmentation .
Cat. No.: HY-W552702
CAS No.: 408335-66-0
Target:
Research Areas:
Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC50: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation .
Cat. No.: HY-101059R
CAS No.: 142720-24-9
FGIN 1-27 (Standard) is the analytical standard of FGIN 1-27 (HY-101059). This product is intended for research and analytical applications. FGIN-1-27 is a blood-brain barrier-penetrant TSPO ligand with a Ki value of 5 nM. FGIN 1-27 inhibits PKC-β, PKA/CREB, p38/ERK MAPK, MITF, tyrosinase, TRP-1, and TRP-2, thereby inhibiting melanogenesis and pigmentation. FGIN-1-27 alleviates X-ray radiation-induced astrocyte mitochondrial hyperfunction, reduces ROS and superoxide production, inhibits excessive activation of A1-type astrocytes, downregulates GFAP and C3 protein expression, and restores astrocyte proliferative capacity. FGIN-1-27 produces anticonvulsant effects in normal mice; in diazepam-withdrawn mice, the brain MDR pathway becomes subsensitive, and the anticonvulsant activity disappears. FGIN-1-27 attenuates pigmentation in zebrafish embryos and ameliorates UVB-induced skin pigmentation in guinea pigs. FGIN-1-27 directly stimulates testicular Leydig cells while upregulating luteinizing hormone levels, causing an acute increase in serum testosterone in male rats. FGIN 1-27 can be used for research related to hyperpigmentation, epilepsy, brain injury, and other diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
