31 Results for "

tetrahydroisoquinolines

" in MedChemExpress (MCE) Product Catalog:
Products (31)

31 Results for "tetrahydroisoquinolines" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-101191
CAS No.: 114899-80-8
Purity:  99.76%
Synonyms: Ecteinascidine 770; Et-770
Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM.
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2
2 Cited Publications
Cat. No.: HY-22385
CAS No.: 5784-74-7
Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.
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1
1 Cited Publications
Cat. No.: HY-N3610
CAS No.: 486-39-5
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription .
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1
1 Cited Publications
Cat. No.: HY-W705106
CAS No.: 3422-42-2
Synonyms: (-)-(S)-Coclaurine hydrochloride; L-Coclaurine hydrochloride
(-)-Coclaurine hydrochloride (compound I) is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. (-)-Coclaurine hydrochloride is a nicotinic acetylcholine receptor (nAChRs) antagonist .
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Cat. No.: HY-148480
CAS No.: 2728780-74-1
Research Areas:  

Cardiovascular Disease

Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) .
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Cat. No.: HY-139570
CAS No.: 2248127-53-7
Synonyms: PM14
Target:  

Bacterial

Ecubectedin (PM14) is a derivative. Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities .
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Cat. No.: HY-132828
CAS No.: 1639303-73-3
Synonyms: LT3001; DHDMIQK(KAP)
Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities .
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Cat. No.: HY-N0137
CAS No.: 6429-04-5
Research Areas:  

Neurological Disease

Tetrahydropapaverine hydrochloride is a tetrahydroisoquinoline (TIQ) compound with inhibitory effects on tryptophan hydroxylase (TPH) (IC50 = 5.7 μM). Tetrahydropapaverine hydrochloride decreases intracellular serotonin content in murine mastocytoma P815 cells, with an IC50 value of 6.2 μM. Tetrahydropapaverine hydrochloride can be used for studies on potential neurotoxicity in monoaminergic neurons .
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Cat. No.: HY-138295
CAS No.: 2578876-75-0
Purity:  99.92%
Target:  

Ras

Research Areas:  

Cancer

KRAS inhibitor-10 selectively and effectively inhibit RAS proteins, and particularly KRAS proteins. KRAS inhibitor-10 is an orally active anti-cancer agent and can be used for cancer research, such as pancreatic cancer, breast cancer, multiple myeloma, leukemia and lung cancer. KRAS inhibitor-10 is a tetrahydroisoquinoline compound (compound 11) extracted from patent WO2021005165 A1 .
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Cat. No.: HY-N0137A
CAS No.: 54417-53-7
Target:  

Drug Intermediate

Research Areas:  

Neurological Disease

(R)-Tetrahydropapaverine hydrochloride is the isomer of Tetrahydropapaverine hydrochloride (HY-N0137), and can be used as an experimental control. Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons .
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Cat. No.: HY-60308A
CAS No.: 57196-62-0
Target:  

Drug Intermediate

Research Areas:  

Others

6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a drug intermediate for synthesis of various active compounds.
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Cat. No.: HY-W029659
CAS No.: 19716-56-4
1-Benzyl-1,2,3,4-tetrahydro-isoquinoline is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Parkinson's Disease .
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Cat. No.: HY-50936S
Synonyms: Ecteinascidin 743-d3; ET-743-d3
Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .
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Cat. No.: HY-42318
CAS No.: 1870821-29-6
Target:  

Drug Intermediate

Research Areas:  

Others

(S)-4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline is a drug intermediate for synthesis of various active compounds.
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Cat. No.: HY-113969
CAS No.: 61563-24-4
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (compound 11), a tetrahydroisoquinoline (THIQ) derivative, is a selective phenylethanolamine N-methyltransferase (PNMT) inhibitor with a Ki value of 0.3 μM. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline can be used in research on psychiatric disorders related to Alzheimer's disease and Parkinson's disease .
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Cat. No.: HY-100296
CAS No.: 89845-16-9
Target:  

Others

Research Areas:  

Inflammation/Immunology

Gastrofensin AN 5, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.
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Cat. No.: HY-22385A
CAS No.: 63283-42-1
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.
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Cat. No.: HY-12395
CAS No.: 874758-58-4
Target:  

Bacterial

Research Areas:  

Cancer

Ecteinascidin analog-1 is a useful intermediate for chemical sythesis of Ecteinascidin analogues; Ecteinascidins is a family of tetrahydroisoquinoline alkaloids with wide range of antitumor and antimicrobial activities.
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Cat. No.: HY-156079
CAS No.: 1071049-42-7
Target:  

Monoamine Oxidase

Research Areas:  

Neurological Disease

Antidepressant agent 5 (Compound 3i) is a 7-substituted tetrahydroisoquinolines derivatives. Antidepressant agent 5 exhibits almost equal antidepressant activity compared with magnoflorine. ntidepressant agent 5 can be used for depressive disorder research .
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Cat. No.: HY-129665
CAS No.: 41498-37-7
Synonyms: (±)-O,O-Dimethylcoclaurine
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K + in rat aortic rings .
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