79 Results for "

thymic

" in MedChemExpress (MCE) Product Catalog:
Products (79)

79 Results for "thymic" in MCE Product Catalog:

10
10 Publications Verification
Cat. No.: HY-N0711
CAS No.: 499-75-2
Synonyms: Cymophenol
Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations .
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6
6 Cited Publications
Cat. No.: HY-B0885
CAS No.: 27220-47-9
Synonyms: (±)-Econazol
Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage .
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1
1 Cited Publications
Cat. No.: HY-P3206
CAS No.: 63958-90-7
Synonyms: Thymulin; thymic factor
Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .
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1
1 Cited Publications
Cat. No.: HY-P3206A
CAS No.: 125117-65-9
Synonyms: Thymulin acetate; thymic factor acetate
Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases .
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1
1 Cited Publications
Cat. No.: HY-P70626
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: thymic stromal lymphopoietin; thymic stroma-derived lymphopoietin; Tslp
Species:  
Source:  
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1
1 Cited Publications
Cat. No.: HY-P700219AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL12; Stromal cell-derived factor 1; SDF-1; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; TPAR1; C-X-C motif chemokine 12; Pre-B cell growth-stimulating factor; PBSF; thymic lymphoma cell-stimulating factor; TLSF; Sdf1
Species:  
Source:  
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Cat. No.: HY-P990774
CAS No.: 2768386-15-6
Synonyms: ASP-7266; TRAB-1; UPB-101

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Verekitug (ASP-7266; TRAB-1; UPB-101) is a human monoclonal antibody targeting the thymic stromal lymphopoietin receptor (TSLPR), with a mean half-life of approximately 20 days. At doses of Verekitug ≥100 mg, complete and sustained TSLPR-specific occupancy is achieved, and the antibody does not bind to IL-7Rα. By inhibiting TSLP-driven inflammatory responses, Verekitug blocks TSLP-induced cell proliferation and TARC expression, while reducing fractional exhaled NO levels, blood eosinophil counts, and levels of IL-5 and IgE. Verekitug significantly improves scores for nasal polyps, nasal congestion and olfactory dysfunction, with favorable safety and good tolerability; potential adverse reactions include headache, upper respiratory tract infection, sinusitis and nasopharyngitis. Verekitug is used in relevant studies on asthma, chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease .
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Cat. No.: HY-N7122
CAS No.: 69558-55-0
Thymopentin is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .
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Cat. No.: HY-P991162
CAS No.: 2981469-90-1
Synonyms: PF-07275315

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Tilrekimig (PF-07275315) is a monoclonal antibody targeting human interleukin-4 (IL-4), interleukin-13 (IL-13) and thymic stromal lymphopoietin (TSLP). Tilrekimig can be used in the research of allergic and inflammatory diseases, such as asthma and atopic dermatitis .
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Cat. No.: HY-P990933
CAS No.: 2803351-66-6
Synonyms: CM-326

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc.
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Cat. No.: HY-P990023
CAS No.: 2622254-57-1
Synonyms: ADX-914

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Bempikibart (ADX-914) is a fully human anti-IL-7Rα antibody that re-regulates adaptive immune function by blocking signaling mediated by both IL-7 and thymic stromal lymphopoietin (TSLP). Bempikibart can be used for the study of atopic dermatitis and alopecia areata .
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Cat. No.: HY-101532
CAS No.: 98169-85-8
Purity:  ≥98.0%
Synonyms: β-CDN3; 6A-deoxy-6A-azido-β-cyclodextrin
Research Areas:  

Others

6A-Azido-6A-deoxy-β-cyclodextrin (β-CDN3) is a site-specifically modified β-cyclodextrin with a single azido group replacing the hydroxyl group at the C6 position. 6A-Azido-6A-deoxy-β-cyclodextrin forms a host-guest inclusion complex with Dexamethasone (HY-14648), localizing the drug within its hydrophobic cavity, which restricts the rotational mobility of the drug and places Dexamethasone in a less polar environment. 6A-Azido-6A-deoxy-β-cyclodextrin acts as a coupling agent to graft β-cyclodextrin onto thermosensitive nanogels via strain-promoted alkyne-azide cycloaddition (SPAAC). 6A-Azido-6A-deoxy-β-cyclodextrin also serves as a click chemistry reagent. It contains an azide group and undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing an alkyne group. It also undergoes strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .
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Cat. No.: HY-P2663
CAS No.: 757942-88-4
Target:  

TNF Receptor

Research Areas:  

Metabolic Disease

Acetyl tetrapeptide-2 is a bio-active peptide that exhibits anti-aging activity. Acetyl tetrapeptide-2 can reduce loss of thymic factors. Acetyl tetrapeptide-2 can increase the stiffness of HaCaT cells. Acetyl tetrapeptide-2 is a stimulator of structural skin elements including collagen and elastin .
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Cat. No.: HY-P99872
CAS No.: 2415207-91-7
Synonyms: CSJ-117; NVP-CSJ117

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ecleralimab (CSJ-117; NVP-CSJ117) is a Fab-IgG1-λ2 antibody targeting the thymic stromal lymphopoietin (TSLP). Ecleralimab significantly attenuates allergen-induced airway responses and inflammation. Ecleralimab can be used for the study of inhaled asthma .
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Cat. No.: HY-P991424

Research Areas:  

Inflammation/Immunology

GSK2618960 is a human monoclonal antibody (mAb) targeting IL-7Ra/CD127. GSK2618960 inhibits IL-7-induced STAT5 phosphorylation. GSK2618960 enhances CD4 T cell proliferation response and increases CD83, CD86, and CD209 expression in PBMCs. GSK2618960 can be used for the research of autoimmune and allergic inflammatory diseases. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-119366
CAS No.: 2068119-11-7
Purity:  99.31%
Target:  

ROR

Research Areas:  

Inflammation/Immunology

S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC50 of <30 nM towards human RORγt in competitive binding assays. S18-000003 shows selectivity for RORγt over other ROR family members (IC50>10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations .
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Cat. No.: HY-N7122A
CAS No.: 89318-88-7
Thymopentin acetate is a biologically active peptide secreted mainly by the epithelial cells of thymic cortex and medulla. Thymopentin acetate is an effective immunomodulatory agent with a short plasma half-life of 30 seconds. Thymopentin acetate enhances the generation of T-cell lineage derived from human embryonic stem cells (hESCs) .
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Cat. No.: HY-14743B
CAS No.: 1029401-59-9
Purity:  99.64%
Synonyms: SCV 07 hydrochloride; Gamma-D-glutamyl-L-tryptophan hydrochloride
Target:  

Bacterial STAT

Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod hydrochloride (SCV 07 hydrochloride) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod hydrochloride (SCV 07 hydrochloride) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2) .
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Cat. No.: HY-P991717
CAS No.: 2928519-36-0
Synonyms: AZD-8630

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Sunakiment (AZD-8630) is a humanized IgG1λ monoclonal antibody inhibitor targeting thymic stromal lymphopoietin (TSLP), which enables direct airway delivery via a dry powder inhaler formulation. Sunakiment binds to TSLP and blocks its pro-inflammatory signal transduction. It is applicable to research on refractory asthma, asthma, and moderate-to-severe asthma .
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Cat. No.: HY-125301
CAS No.: 107489-37-2
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

Thymoctonan (THF-γ2) is the immunomodulatory octapeptide, thymic humoral factor γ2. Thymoctonan has the half-life less than 6 min at 37 °C in blood from human, rat and mouse .
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