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Results for "

triphenylphosphonium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (1) Bacterial (2) Biochemical Assay Reagents (4) CD38 (1) Drug Intermediate (2) Endogenous Metabolite (1) Endothelin Receptor (1) Fluorescent Dye (1) Fungal (2) HSP (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (3) Oxidative Phosphorylation (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (4) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126124

AP39 5+ Cited Publications	Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease
AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H₂S) donor. AP39 increases intracellular H₂S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research .

HY-135869

Mito-apocynin (C11) 3 Publications Verification	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .

HY-147696

SMTIN-T140	HSP AMPK Reactive Oxygen Species (ROS)	Cancer
SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC₅₀ of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-I0607A

*(1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium* bromide**	Biochemical Assay Reagents	Others
(1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide is an important raw material and intermediate in organic synthesis, pharmaceuticals, agrochemicals, and dyes. (1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide is widely used as an organophosphorus catalyst .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-N15837

DSPE-PEG(2000)-N-Triphenylphosphonium	Biochemical Assay Reagents	Others
DSPE-PEG(2000)-N-Triphenylphosphonium is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.

HY-173549

CPPA-TPP CPPA-triphenylphosphonium	Drug Intermediate	Cancer
CPPA-TPP (CPPA-Triphenylphosphonium) is a compound conjugated to the mitochondria-targeting moiety triphenylphosphonium (TPP). CPPA-TPP can be used in the synthesis of nanoparticles that release Camptothecin (HY-16560) in a reactive oxygen species dependent manner, leading to cancer cell death .

HY-N16300

Mito-laurdan bromide	Fluorescent Dye	Others
Mito-laurdan bromide, a derivative of Laurdan (HY-D0080), is a fluorescent probe. Mito-laurdan bromide contains a cationic triphenylphosphonium moiety, which accumulates at the inner mitochondrial membrane due to its negative membrane potential, connected via a 3 carbon linker .

HY-186012

TPP@CUR	Drug Intermediate	Others
TPP@CUR is the product formed by the esterification reaction between Curcumin (HY-N0005) and (5-hydroxy-5-oxopentyl)triphenylphosphonium bromide (TPP). TPP@CUR can be used to synthesize Ser@TPP@CUR (HY-151342), which can then be used in studies of acute kidney injury .

HY-W010882S

*(4-Carboxybutyl-d4)triphenylphosphonium* bromide**	Isotope-Labeled Compounds	Others
(4-Carboxybutyl-d₄)triphenylphosphonium (bromide) is the deuterium labeled (4-Carboxybutyl)triphenylphosphonium bromide .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-Y1033S

*Methyl-triphenylphosphonium-d3 bromide* Phosphonium, methyltriphenyl-, bromide (8CI,9CI)-d₃; M 0779-d₃; MTPPB-d₃; Phosphonium,methyltriphenyl-,bromide-d₃; Methyltriphenylphosphonium bromide-d₃	Isotope-Labeled Compounds	Others
Methyl-triphenylphosphonium-d₃ (bromide) is the deuterium labeled Methyl-triphenylphosphonium bromide .

HY-158918

4-CF3-TPP-DC 4-CF3-triphenylphosphonium-DC	Biochemical Assay Reagents	Others
4-CF3-TPP-DC (4-CF3-Triphenylphosphonium-DC) is an inert mitochondrial targeting carrier, that delivers target drugs and probes to mitochondria without causing mitochondrial depolarization and cytotoxicity in cell C2C12 .

HY-129303

AP219	Endogenous Metabolite	Metabolic Disease
AP39 (Item No. 17100) is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.

HY-135868

Mito-apocynin (C2)	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .

HY-163073

Anti-MRSA agent 9	Bacterial	Infection
Anti-MRSA agent 9 (compound 39) shows antibacterial effects against clinically isolated methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 1 μg/ml. Anti-MRSA agent 9 also shows anti-MRSA efficacy in vivo .

HY-176775

TPP-IOA	Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis	Neurological Disease
TPP-IOA is a cytochrome c peroxidase inhibitor. TPP-IOA inhibits apoptosis by preventing cardiolipin oxidation and cytochrome c release to the cytosol. TPP-IOA disrupts oxidative phosphorylation in isolated mitochondria. TPP-IOA inhibits cell death in SH-SY5Y cells grown in glucose, but not galactose. TPP-IOA causes mitochondrial depolarization and network fragmentation. TPP-lOA mitigates radiation induced death in mice .

HY-149067

Antifungal agent 47	Fungal	Infection
Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide .

HY-151556

Antifungal agent 45	Fungal	Infection
Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC₅₀ value of about 5 μM .

HY-W103952R

*((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium* bromide (Standard)**	Reference Standards
((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium bromide (Standard) is the analytical standard of ((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium bromide. This product is intended for research and analytical applications.

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

*(1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium* bromide**	Biochemical Assay Reagents
(1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide is an important raw material and intermediate in organic synthesis, pharmaceuticals, agrochemicals, and dyes. (1-Ethoxy-1-oxopropan-2-yl)triphenylphosphonium bromide is widely used as an organophosphorus catalyst .

Cat. No.	Product Name	Target	Research Area

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15837

DSPE-PEG(2000)-N-Triphenylphosphonium	Lipid	Biochemical Assay Reagents
DSPE-PEG(2000)-N-Triphenylphosphonium is functionalized PEG lipid that can be used to synthesize lipid nanoparticles for drug delivery.

HY-N16300

Mito-laurdan bromide	Lipid	Fluorescent Dye
Mito-laurdan bromide, a derivative of Laurdan (HY-D0080), is a fluorescent probe. Mito-laurdan bromide contains a cationic triphenylphosphonium moiety, which accumulates at the inner mitochondrial membrane due to its negative membrane potential, connected via a 3 carbon linker .

Cat. No.	Product Name	Chemical Structure

HY-W010882S

*(4-Carboxybutyl-d4)triphenylphosphonium* bromide**
(4-Carboxybutyl-d₄)triphenylphosphonium (bromide) is the deuterium labeled (4-Carboxybutyl)triphenylphosphonium bromide .

HY-Y1033S

*Methyl-triphenylphosphonium-d3 bromide*
Methyl-triphenylphosphonium-d₃ (bromide) is the deuterium labeled Methyl-triphenylphosphonium bromide .

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triphenylphosphonium

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products