(E)-Octinoxate
Based on 1 Customer Validation
(E)-Octinoxate ((E)-Octyl methoxycinnamate) is a cinnamate ester organic UVB sunscreen and the (E) isomer of Octinoxate (HY-B1234). (E)-Octinoxate absorbs ultraviolet radiation, with its absorption range extending into UVA. (E)-Octinoxate undergoes UV-driven trans-cis photoisomerization in dilute solution to form a photostationary mixture; in the aggregated state, it undergoes irreversible photodegradation to generate multiple photoproducts, including species that absorb UVA.
For research use only. We do not sell to patients.
- Purity : 99.50%
- CAS No.: 83834-59-7
- Formula: C18H26O3
- Molecular Weight:290.40
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
(E)-Octinoxate in aggregated form produces UVA-absorbing photoproducts that sensitize singlet oxygen under 405 nm irradiation, as detected by SOSG fluorescence[1].
(E)-Octinoxate (1.56-25 μg/mL; 3 h) induces comet-assay DNA damage in TK-6 human lymphoblastoid cells only at 12.5 and 25 μg/mL, with an in vitro NOEC of 0.0054 mg/mL[4].
(E)-Octinoxate (1.56-25 μg/mL; 3 h) induces comet-assay DNA damage in HL1-hT1 adult human liver stem cells at 25 μg/mL, with an in vitro NOEC of 0.0236 mg/mL[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 83834-59-7
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Appearance Liquid (Density: 1.00±0.06 g/cm3)
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Molecular Weight 290.40
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Formula C18H26O3
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Color Colorless to light yellow
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SMILES
O=C(/C=C/C1=CC=C(C=C1)OC)OCC(CCCC)CC
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Synonyms
(E)-Octyl methoxycinnamate; (E)-2-Ethylhexyl 4-methoxycinnamate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : ≥ 200 mg/mL (688.71 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (276 KB)
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SDS (398 KB)
- English - EN (398 KB)
- Français - FR (398 KB)
- Deutsch - DE (398 KB)
- Norwegian - NO (398 KB)
- Español - ES (398 KB)
- Swedish - SV (398 KB)
- Italian - IT (398 KB)
- Korean - KR (398 KB)
- Portuguese - PT (398 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4435 mL | 17.2176 mL | 34.4353 mL | 86.0882 mL |
| 5 mM | 0.6887 mL | 3.4435 mL | 6.8871 mL | 17.2176 mL | |
| 10 mM | 0.3444 mL | 1.7218 mL | 3.4435 mL | 8.6088 mL | |
| 15 mM | 0.2296 mL | 1.1478 mL | 2.2957 mL | 5.7392 mL | |
| 20 mM | 0.1722 mL | 0.8609 mL | 1.7218 mL | 4.3044 mL | |
| 25 mM | 0.1377 mL | 0.6887 mL | 1.3774 mL | 3.4435 mL | |
| 30 mM | 0.1148 mL | 0.5739 mL | 1.1478 mL | 2.8696 mL | |
| 40 mM | 0.0861 mL | 0.4304 mL | 0.8609 mL | 2.1522 mL | |
| 50 mM | 0.0689 mL | 0.3444 mL | 0.6887 mL | 1.7218 mL | |
| 60 mM | 0.0574 mL | 0.2870 mL | 0.5739 mL | 1.4348 mL | |
| 80 mM | 0.0430 mL | 0.2152 mL | 0.4304 mL | 1.0761 mL | |
| 100 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8609 mL |
(E)-Octinoxate Related Classifications
HY-B1234A Related Classifications
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Keywords
- (E)-Octinoxate
- 83834-59-7
- (E)-Octyl methoxycinnamate
- (E)-2-Ethylhexyl 4-methoxycinnamate
- DNA/RNA Synthesis
- DNA strand breaks
- UVB filter
- endocrine-disrupting effects
- genotoxicity
- human liver stem cells
- photodegradation
- photodimerisation
- photoisomerisation
- singlet oxygen sensitization
- ultraviolet radiation
- Inhibitor
- inhibitor
- inhibit