Fadolmidine
Fadolmidine is a novel, selective α2-adrenoceptor (α2-AR) agonist with EC50 values of 0.4 nM, 4.9 nM and 0.5 nM for 2A, 2B and 2C, respectively. Fadolmidine has been effective against various submodalities of pain such as heat pain, mechanical pain, and visceral pain. Fadolmidine inhibits also electrically evoked contractions in rat vas deferens.
For research use only. We do not sell to patients.
- CAS No.: 189353-31-9
- Formula: C13H14N2O
- Molecular Weight:214.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adrenergic Receptor Isoforms
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Biological Activity
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α2-adrenergic receptor |
Chemical Information
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CAS No. 189353-31-9
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Molecular Weight 214.26
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Formula C13H14N2O
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SMILES
OC1=CC=C2C(C(CC2)CC3=CN=CN3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pertovaara A. Antinociceptive properties of fadolmidine (MPV-2426), a novel alpha2-adrenoceptor agonist. CNS Drug Rev. 2004 Summer;10(2):117-26. [Content Brief]
[2]. Lehtimäki J, et al. In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action. Eur J Pharmacol. 2008 Dec 3;599(1-3):65-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fadolmidine Related Classifications
HY-106388 Related Classifications
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