SLU-11695
SLU-11695 is an orally active antiparasitic agent belonging to the pyrazolo[3,4-d]pyrimidine benzoxaborole class. SLU-11695 inhibits the asexual reproduction of Cryptosporidium parvum, eliminates parasite shedding, and prevents post-exposure recurrence. SLU-11695 can be used in the research of cryptosporidiosis.
For research use only. We do not sell to patients.
- CAS No.: 3065121-95-8
- Formula: C23H23BFN5O2
- Molecular Weight:431.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-8 | EC50 |
0.025 μM
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Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.
Inhibition of Cryptosporidium parvum growth in human colon carcinoma HCT-8 cell monolayers infected with C. parvum (Iowa strain) oocysts, assessed via automated fluorescence microscopy after 48 h incubation with the compound following a 3-hour invasion period.
|
42593902 |
| HCT-8 | CC50 |
~77 μM
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Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.
Host cell cytotoxicity against human colon carcinoma HCT-8 cells, assessed during the Cryptosporidium parvum growth inhibition assay after 48 h incubation with the compound.
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42593902 |
In Vitro
SLU-11695 (0.025 μM; 48 h) potently inhibits Cryptosporidium parvum growth in HCT-8 cells with an EC50 of 0.025 μM and exhibits >3000-fold selectivity over host cell cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (male, 4-5 weeks old)[1]
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Dosage:50 mg/kg
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Administration:p.o.; twice daily; 4 days
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Result:Eliminated *C. parvum* fecal shedding with no evidence of relapse up to 8 days after dosing cessation.
Showed no apparent side effects in all tested mice.
Chemical Information
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CAS No. 3065121-95-8
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Molecular Weight 431.27
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Formula C23H23BFN5O2
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SMILES
CCC1=NN(C)C2=NC(C3=CC=C(B(O)OC4C)C4=C3)=NC(NCC5=CC=C(F)C=C5)=C21
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SLU-11695 Related Classifications
HY-189004 Related Classifications
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